STRINGSTRING
PLK1 PLK1 BCCIP BCCIP MAPRE1-2 MAPRE1-2 ENSVVUP00000007132 ENSVVUP00000007132 CCDC57 CCDC57 KIF2A KIF2A ENSVVUP00000005911 ENSVVUP00000005911 ARL3 ARL3 MAK MAK NEDD9 NEDD9 INCENP INCENP NUDCD2 NUDCD2 DCUN1D5 DCUN1D5 CDK5RAP2 CDK5RAP2 MTCL1 MTCL1 CEP85 CEP85 ANKFN1 ANKFN1 ENSVVUP00000015834 ENSVVUP00000015834 AUNIP AUNIP CEP295 CEP295 UNC119 UNC119 DCDC1 DCDC1 SBDS SBDS AGBL5 AGBL5 MAPRE3 MAPRE3 AFMID AFMID HAUS5 HAUS5 ENSVVUP00000019958 ENSVVUP00000019958 KBTBD8 KBTBD8 RAB11A RAB11A SPATA5L1 SPATA5L1 HMMR HMMR ASPM ASPM CSNK1A1 CSNK1A1 LOC112907286 LOC112907286 SPDL1 SPDL1 GEM GEM CALM3 CALM3 SHCBP1 SHCBP1 AURKC AURKC ECT2 ECT2 RMDN1 RMDN1 ENSVVUP00000002079 ENSVVUP00000002079 CHMP4C CHMP4C KIF14 KIF14 TBL1XR1 TBL1XR1 PSRC1 PSRC1 CDC6 CDC6 HAUS6 HAUS6 POLB POLB SGO1 SGO1 KIF18A KIF18A HAAO HAAO WDR62 WDR62 TBCCD1 TBCCD1 LOC112915139 LOC112915139 NUDC NUDC CNTRL CNTRL RSKR RSKR SPAG5 SPAG5 CEP44 CEP44 FAM161A FAM161A MAPRE1 MAPRE1 KYNU KYNU MAP1S MAP1S LOC112908355 LOC112908355 CENPE CENPE WDR97 WDR97 KATNAL1 KATNAL1 UBL3 UBL3 SHCBP1L SHCBP1L HAUS2 HAUS2 ENSVVUP00000011611 ENSVVUP00000011611 CEP19 CEP19 SPAST SPAST RAE1 RAE1 TBCK TBCK CTNND2 CTNND2 UBXN2B UBXN2B LOC112934252 LOC112934252 CALM1 CALM1 KIF18B KIF18B DDX11 DDX11 KNTC1 KNTC1 CSPP1 CSPP1 RMDN2 RMDN2 CTDP1 CTDP1 TBL1X TBL1X CYLD CYLD TNKS TNKS PKP4 PKP4 IDO1 IDO1 BRCC3 BRCC3 GPANK1 GPANK1 CHMP5 CHMP5 KIF20B KIF20B KIF11 KIF11 MZT2B MZT2B CCDC155 CCDC155 MMS19 MMS19 RACGAP1 RACGAP1 KLHL22 KLHL22 TUBG1 TUBG1 TUBG1-2 TUBG1-2 CDC25B CDC25B TDO2 TDO2 MAP9 MAP9 EML4 EML4 ENSVVUP00000034938 ENSVVUP00000034938 RAB11B RAB11B ANXA11 ANXA11 ENSVVUP00000035680 ENSVVUP00000035680 CCDC117 CCDC117 SPOUT1 SPOUT1 HASPIN HASPIN NOL9 NOL9 RMDN3 RMDN3 MAPKBP1 MAPKBP1 KAT5 KAT5 CLASP1 CLASP1 CIAO1 CIAO1 SAC3D1 SAC3D1 HSPA2 HSPA2 ESPL1 ESPL1 ANKRD53 ANKRD53 AAAS AAAS KATNAL2 KATNAL2 CDADC1 CDADC1 TPT1 TPT1 TTL TTL CKAP2L CKAP2L ENSVVUP00000040212 ENSVVUP00000040212 XIAP XIAP RCC2 RCC2 DHX35 DHX35 FAM83D FAM83D DLGAP5 DLGAP5 NIN NIN ENSVVUP00000042159 ENSVVUP00000042159 CENPV CENPV NCOR1 NCOR1 CDC42 CDC42 TPX2 TPX2 CENPF CENPF FAM110A FAM110A HSF1 HSF1 YPEL5 YPEL5 FBXO5 FBXO5 MAP10 MAP10 ENSVVUP00000009373 ENSVVUP00000009373 CCDC69 CCDC69 CCSAP CCSAP PRC1 PRC1 SIRT2 SIRT2 CEP95 CEP95
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLK1Serine/threonine-protein kinase PLK. (607 aa)
BCCIPBRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family. (314 aa)
MAPRE1-2Microtubule-associated protein RP/EB family member 1. (126 aa)
ENSVVUP00000007132annotation not available (147 aa)
CCDC57Coiled-coil domain-containing protein 57 isoform X2. (978 aa)
KIF2AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (729 aa)
ENSVVUP00000005911annotation not available (91 aa)
ARL3ADP-ribosylation factor-like protein 3; Belongs to the small GTPase superfamily. Arf family. (182 aa)
MAKSerine/threonine-protein kinase MAK. (648 aa)
NEDD9Enhancer of filamentation 1 isoform X2. (834 aa)
INCENPInner centromere protein isoform X1. (929 aa)
NUDCD2nudC domain-containing protein 2. (192 aa)
DCUN1D5DCN1-like protein. (482 aa)
CDK5RAP2CDK5 regulatory subunit-associated protein 2. (1889 aa)
MTCL1Microtubule cross-linking factor 1 isoform X1. (1688 aa)
CEP85Centrosomal protein of 85 kDa. (767 aa)
ANKFN1Ankyrin repeat and fibronectin type-III domain-containing protein 1. (416 aa)
ENSVVUP00000015834annotation not available (109 aa)
AUNIPAurora kinase A and ninein-interacting protein. (416 aa)
CEP295Centrosomal protein of 295 kDa isoform X1. (2477 aa)
UNC119Protein unc-119 homolog A. (242 aa)
DCDC1Doublecortin domain-containing protein 1. (1744 aa)
SBDSRibosome maturation protein SBDS. (250 aa)
AGBL5Cytosolic carboxypeptidase-like protein 5 isoform X1. (908 aa)
MAPRE3Microtubule-associated protein RP/EB family member 3 isoform X1. (281 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (439 aa)
HAUS5HAUS augmin-like complex subunit 5. (633 aa)
ENSVVUP00000019958annotation not available (191 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8 isoform X1. (696 aa)
RAB11ARas-related protein Rab-11A. (216 aa)
SPATA5L1Spermatogenesis-associated protein 5-like protein 1 isoform X1. (755 aa)
HMMRLOW QUALITY PROTEIN: hyaluronan mediated motility receptor. (740 aa)
ASPMLOW QUALITY PROTEIN: abnormal spindle-like microcephaly-associated protein. (3515 aa)
CSNK1A1Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (384 aa)
LOC112907286Spindle and kinetochore-associated protein 2. (93 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (621 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
CALM3Calmodulin-1; Belongs to the calmodulin family. (149 aa)
SHCBP1SHC SH2 domain-binding protein 1. (702 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (309 aa)
ECT2LOW QUALITY PROTEIN: protein ECT2. (1010 aa)
RMDN1Regulator of microtubule dynamics protein 1 isoform X1. (317 aa)
ENSVVUP00000002079annotation not available (83 aa)
CHMP4CCharged multivesicular body protein 4c. (236 aa)
KIF14Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1635 aa)
TBL1XR1F-box-like/WD repeat-containing protein TBL1XR1 isoform X1. (573 aa)
PSRC1Proline/serine-rich coiled-coil protein 1 isoform X1. (364 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (516 aa)
HAUS6HAUS augmin-like complex subunit 6. (954 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
SGO1Shugoshin 1. (524 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (899 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase. (337 aa)
WDR62LOW QUALITY PROTEIN: WD repeat-containing protein 62. (1558 aa)
TBCCD1TBCC domain-containing protein 1. (557 aa)
LOC112915139Protein yippee-like 5. (121 aa)
NUDCNuclear migration protein nudC. (398 aa)
CNTRLCentriolin. (2378 aa)
RSKRUncharacterized serine/threonine-protein kinase SgK494 isoform X2. (393 aa)
SPAG5Sperm-associated antigen 5 isoform X3. (1088 aa)
CEP44Centrosomal protein of 44 kDa isoform X1. (386 aa)
FAM161AProtein FAM161A. (667 aa)
MAPRE1Microtubule-associated protein RP/EB family member 1. (195 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (472 aa)
MAP1SMicrotubule-associated protein 1S isoform X1. (1035 aa)
LOC112908355LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like. (270 aa)
CENPECentromere-associated protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2396 aa)
WDR97WD repeat-containing protein 97. (1391 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (532 aa)
UBL3Ubiquitin-like protein. (121 aa)
SHCBP1LTesticular spindle-associated protein SHCBP1L. (639 aa)
HAUS2HAUS augmin-like complex subunit 2 isoform X1. (235 aa)
ENSVVUP00000011611annotation not available (205 aa)
CEP19Centrosomal protein of 19 kDa. (163 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (540 aa)
RAE1mRNA export factor. (371 aa)
TBCKTBC domain-containing protein kinase-like protein. (893 aa)
CTNND2Catenin delta-2. (754 aa)
UBXN2BUBX domain-containing protein 2B. (330 aa)
LOC112934252Catenin delta-2-like isoform X1. (227 aa)
CALM1Calmodulin 1. (149 aa)
KIF18BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (860 aa)
DDX11ATP-dependent DNA helicase DDX11. (961 aa)
KNTC1Kinetochore-associated protein 1. (2221 aa)
CSPP1Centrosome and spindle pole-associated protein 1 isoform X1. (1144 aa)
RMDN2Regulator of microtubule dynamics protein 2. (504 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (878 aa)
TBL1XF-box-like/WD repeat-containing protein TBL1X isoform X2. (526 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD isoform X2; Belongs to the peptidase C19 family. (972 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
PKP4Plakophilin-4 isoform X1. (1208 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (388 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (263 aa)
GPANK1G patch domain and ankyrin repeat-containing protein 1. (351 aa)
CHMP5Charged multivesicular body protein 5. (288 aa)
KIF20BKinesin-like protein KIF20B isoform X3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1772 aa)
KIF11Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1099 aa)
MZT2BMitotic spindle organizing protein 2B. (214 aa)
CCDC155Protein KASH5. (616 aa)
MMS19MMS19 nucleotide excision repair protein homolog isoform X2. (1028 aa)
RACGAP1Rac GTPase-activating protein 1 isoform X2. (632 aa)
KLHL22Kelch-like protein 22. (634 aa)
TUBG1Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (491 aa)
TUBG1-2Tubulin gamma-1 chain. (251 aa)
CDC25BM-phase inducer phosphatase 2 isoform X2. (533 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
MAP9Microtubule-associated protein 9. (1085 aa)
EML4Echinoderm microtubule-associated protein-like 4 isoform X1. (1018 aa)
ENSVVUP00000034938annotation not available (125 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
ANXA11Annexin. (534 aa)
ENSVVUP00000035680annotation not available (126 aa)
CCDC117Coiled-coil domain-containing protein 117. (258 aa)
SPOUT1Putative methyltransferase C9orf114 homolog isoform X1. (358 aa)
HASPINSerine/threonine-protein kinase haspin. (779 aa)
NOL9Polynucleotide 5'-hydroxyl-kinase NOL9. (1070 aa)
RMDN3Regulator of microtubule dynamics protein 3. (503 aa)
MAPKBP1Mitogen-activated protein kinase-binding protein 1 isoform X1. (1503 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa)
CLASP1CLIP-associating protein 1 isoform X4. (1551 aa)
CIAO1Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family. (339 aa)
SAC3D1SAC3 domain-containing protein 1. (358 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (637 aa)
ESPL1Separin. (2103 aa)
ANKRD53Ankyrin repeat domain-containing protein 53. (489 aa)
AAASAladin isoform X1. (546 aa)
KATNAL2Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (588 aa)
CDADC1Cytidine and dCMP deaminase domain-containing protein 1. (490 aa)
TPT1Translationally-controlled tumor protein; Belongs to the TCTP family. (195 aa)
TTLTubulin--tyrosine ligase. (377 aa)
CKAP2LCytoskeleton-associated protein 2-like. (746 aa)
ENSVVUP00000040212annotation not available (169 aa)
XIAPE3 ubiquitin-protein ligase XIAP. (493 aa)
RCC2Protein RCC2. (519 aa)
DHX35Probable ATP-dependent RNA helicase DHX35. (771 aa)
FAM83DProtein FAM83D. (420 aa)
DLGAP5Disks large-associated protein 5. (845 aa)
NINNinein isoform X2. (2134 aa)
ENSVVUP00000042159annotation not available (59 aa)
CENPVCentromere protein V. (326 aa)
NCOR1Nuclear receptor corepressor 1 isoform X5. (2521 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
TPX2Targeting protein for Xklp2. (740 aa)
CENPFCentromere protein F. (3062 aa)
FAM110AProtein FAM110A. (422 aa)
HSF1Heat shock factor protein 1 isoform X2. (554 aa)
YPEL5Protein yippee-like; Belongs to the yippee family. (121 aa)
FBXO5F-box only protein 5. (448 aa)
MAP10Microtubule-associated protein 10. (863 aa)
ENSVVUP00000009373annotation not available (154 aa)
CCDC69Coiled-coil domain-containing protein 69. (293 aa)
CCSAPCentriole, cilia and spindle-associated protein. (270 aa)
PRC1Protein regulator of cytokinesis 1 isoform X1. (567 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (412 aa)
CEP95Centrosomal protein of 95 kDa. (816 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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