(43 nodes) Catalytic step 2 spliceosome network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRRM2	Serine/arginine repetitive matrix protein 2 isoform X1. (2754 aa)
	ENSVVUP00000042332	annotation not available (107 aa)
	WDR25	WD repeat-containing protein 25. (539 aa)
	SRRM1	LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 1. (903 aa)
	SNRNP200	U5 small nuclear ribonucleoprotein 200 kDa helicase. (2141 aa)
	XAB2	pre-mRNA-splicing factor SYF1. (885 aa)
	PPIL1	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (276 aa)
	AQR	RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1484 aa)
	DDX41	Probable ATP-dependent RNA helicase DDX41. (649 aa)
	SNRPB	Small nuclear ribonucleoprotein-associated protein. (240 aa)
	WDR83	WD repeat domain-containing protein 83 isoform X1. (315 aa)
	ESS2	Splicing factor ESS-2 homolog. (478 aa)
	SRRM3	Serine/arginine repetitive matrix protein 3. (246 aa)
	ENSVVUP00000031555	annotation not available (182 aa)
	DDX23	Probable ATP-dependent RNA helicase DDX23. (820 aa)
	SNRPG-2	Small nuclear ribonucleoprotein G. (76 aa)
	PPIL3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (143 aa)
	PRPF4B	Serine/threonine-protein kinase PRP4 homolog isoform X1. (1042 aa)
	ENSVVUP00000025189	annotation not available (102 aa)
	ZCCHC8	Zinc finger CCHC domain-containing protein 8 isoform X1. (773 aa)
	ISY1	pre-mRNA-splicing factor ISY1 homolog. (285 aa)
	EFTUD2	116 kDa U5 small nuclear ribonucleoprotein component. (972 aa)
	ENSVVUP00000022877	annotation not available (117 aa)
	GPATCH1	G patch domain-containing protein 1. (931 aa)
	CRNKL1	Crooked neck-like protein 1. (834 aa)
	LOC112928885	Heterogeneous nuclear ribonucleoprotein C-like isoform X1. (305 aa)
	ENSVVUP00000015561	annotation not available (77 aa)
	ENSVVUP00000015434	annotation not available (1708 aa)
	HNRNPC	Heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1. (344 aa)
	RBM22	pre-mRNA-splicing factor RBM22. (420 aa)
	CDC40	pre-mRNA-processing factor 17. (663 aa)
	PPWD1	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1. (646 aa)
	ENSVVUP00000007289	annotation not available (69 aa)
	LOC112908211	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (375 aa)
	EFL1	Elongation factor-like GTPase 1. (1156 aa)
	SNW1	SNW domain-containing protein 1. (536 aa)
	SNRPD2	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (112 aa)
	SNRPG	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
	ENSVVUP00000001067	annotation not available (72 aa)
	ENSVVUP00000000755	annotation not available (105 aa)
	ENSVVUP00000000470	annotation not available (62 aa)
	ENSVVUP00000000309	annotation not available (109 aa)
	ALYREF	THO complex subunit 4. (217 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALYREF	CDC40	ENSVVUP00000000279	ENSVVUP00000008610	THO complex subunit 4.	pre-mRNA-processing factor 17.	0.913
ALYREF	DDX23	ENSVVUP00000000279	ENSVVUP00000026752	THO complex subunit 4.	Probable ATP-dependent RNA helicase DDX23.	0.510
ALYREF	DDX41	ENSVVUP00000000279	ENSVVUP00000036244	THO complex subunit 4.	Probable ATP-dependent RNA helicase DDX41.	0.818
ALYREF	EFTUD2	ENSVVUP00000000279	ENSVVUP00000024690	THO complex subunit 4.	116 kDa U5 small nuclear ribonucleoprotein component.	0.757
ALYREF	ENSVVUP00000000470	ENSVVUP00000000279	ENSVVUP00000000470	THO complex subunit 4.	annotation not available	0.597
ALYREF	ENSVVUP00000001067	ENSVVUP00000000279	ENSVVUP00000001067	THO complex subunit 4.	annotation not available	0.597
ALYREF	ENSVVUP00000007289	ENSVVUP00000000279	ENSVVUP00000007289	THO complex subunit 4.	annotation not available	0.597
ALYREF	ENSVVUP00000015561	ENSVVUP00000000279	ENSVVUP00000015561	THO complex subunit 4.	annotation not available	0.413
ALYREF	ENSVVUP00000022877	ENSVVUP00000000279	ENSVVUP00000022877	THO complex subunit 4.	annotation not available	0.466
ALYREF	ENSVVUP00000025189	ENSVVUP00000000279	ENSVVUP00000025189	THO complex subunit 4.	annotation not available	0.553
ALYREF	ENSVVUP00000031555	ENSVVUP00000000279	ENSVVUP00000031555	THO complex subunit 4.	annotation not available	0.553
ALYREF	HNRNPC	ENSVVUP00000000279	ENSVVUP00000012758	THO complex subunit 4.	Heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1.	0.553
ALYREF	LOC112928885	ENSVVUP00000000279	ENSVVUP00000016610	THO complex subunit 4.	Heterogeneous nuclear ribonucleoprotein C-like isoform X1.	0.553
ALYREF	PPIL1	ENSVVUP00000000279	ENSVVUP00000036851	THO complex subunit 4.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.918
ALYREF	PPIL3	ENSVVUP00000000279	ENSVVUP00000025946	THO complex subunit 4.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.825
ALYREF	PPWD1	ENSVVUP00000000279	ENSVVUP00000007502	THO complex subunit 4.	Peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1.	0.912
ALYREF	PRPF4B	ENSVVUP00000000279	ENSVVUP00000025902	THO complex subunit 4.	Serine/threonine-protein kinase PRP4 homolog isoform X1.	0.750
ALYREF	SNRPB	ENSVVUP00000000279	ENSVVUP00000035666	THO complex subunit 4.	Small nuclear ribonucleoprotein-associated protein.	0.413
ALYREF	SNRPD2	ENSVVUP00000000279	ENSVVUP00000004049	THO complex subunit 4.	Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.	0.466
ALYREF	SNRPG	ENSVVUP00000000279	ENSVVUP00000003669	THO complex subunit 4.	Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.	0.597