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CCN1 CCN1 NID2 NID2 SLIT1 SLIT1 SNED1 SNED1 OIT3 OIT3 ERBB3 ERBB3 SCARF1 SCARF1 EPHA6 EPHA6 PROS1 PROS1 EPHA3 EPHA3 NOTCH3 NOTCH3 CRIM1 CRIM1 CCN4 CCN4 MATN4 MATN4 LRP1 LRP1 FBLN2 FBLN2 LDLR LDLR EGF EGF CUBN CUBN VWCE VWCE LTBP2 LTBP2 JAG2 JAG2 IGFBP1 IGFBP1 LTBP4 LTBP4 EPHA5 EPHA5 EPHB1 EPHB1 INSRR INSRR CRB1 CRB1 CD93 CD93 SLIT3 SLIT3 RSPO1 RSPO1 UMOD UMOD CRTAC1 CRTAC1 EPHB4 EPHB4 CRELD1 CRELD1 SCARF2 SCARF2 FBLN5 FBLN5 FRAS1 FRAS1 EGFL8 EGFL8 CELSR1 CELSR1 GPSM3 GPSM3 CRELD2 CRELD2 HTRA3 HTRA3 DNER DNER EPHB2 EPHB2 EGFL7 EGFL7 SCUBE3 SCUBE3 TNFRSF9 TNFRSF9 NOTCH1 NOTCH1 DLL4 DLL4 LRP4 LRP4 ADGRE5 ADGRE5 FBN3 FBN3 LOC112908104 LOC112908104 CD248 CD248 EFEMP2 EFEMP2 MEGF6 MEGF6 LTBP3 LTBP3 CCN2 CCN2 TMEM67 TMEM67 PCSK5 PCSK5 SUSD1 SUSD1 KIAA1324L KIAA1324L ERBB2 ERBB2 SCUBE2 SCUBE2 IGFBP6 IGFBP6 INSR INSR FBLN1 FBLN1 SVEP1 SVEP1 EPHA2 EPHA2 FBN2 FBN2 LAMA2 LAMA2 CELSR2 CELSR2 RSPO3 RSPO3 KIAA1324 KIAA1324 IGFBP4 IGFBP4 KAZALD1 KAZALD1 SCUBE1 SCUBE1 VLDLR VLDLR FURIN FURIN DLL1 DLL1 IGFBP5 IGFBP5 CCN5 CCN5 RSPO4 RSPO4 EGFL6 EGFL6 EYS EYS ERBB4 ERBB4 NID1 NID1 CRB2 CRB2 HMCN1 HMCN1 EGFR EGFR NELL1 NELL1 EFEMP1 EFEMP1 MATN2 MATN2 LTBP1 LTBP1 FAT1 FAT1 EPHB3 EPHB3 BRINP3 BRINP3 GAS6 GAS6 FAT4 FAT4 EPHA7 EPHA7 IGF1R IGF1R ESM1 ESM1 NPNT NPNT RSPO2 RSPO2 NELL2 NELL2 LRP2 LRP2 EPHA1 EPHA1 VWDE VWDE FBN1 FBN1 ADGRE1 ADGRE1 CCN3 CCN3 JAG1 JAG1 MATN3 MATN3 PCSK6 PCSK6 NOTCH2 NOTCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCN1Protein CYR61 isoform X1. (520 aa)
NID2Nidogen-2 isoform X1. (1469 aa)
SLIT1Slit homolog 1 protein. (1442 aa)
SNED1Sushi, nidogen and EGF-like domain-containing protein 1. (1398 aa)
OIT3Oncoprotein-induced transcript 3 protein. (546 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1342 aa)
SCARF1Scavenger receptor class F member 1. (760 aa)
EPHA6Ephrin type-A receptor 6 isoform X4. (804 aa)
PROS1Vitamin K-dependent protein S. (673 aa)
EPHA3Ephrin type-A receptor 3. (983 aa)
NOTCH3LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3. (2326 aa)
CRIM1Cysteine-rich motor neuron 1 protein. (1021 aa)
CCN4WNT1-inducible-signaling pathway protein 1. (362 aa)
MATN4Matrilin-4 isoform X3. (637 aa)
LRP1Prolow-density lipoprotein receptor-related protein 1. (4498 aa)
FBLN2Fibulin-2 isoform X1. (1279 aa)
LDLRLow-density lipoprotein receptor. (866 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1211 aa)
CUBNCubilin. (3627 aa)
VWCEVon Willebrand factor C and EGF domain-containing protein isoform X1. (910 aa)
LTBP2Latent-transforming growth factor beta-binding protein 2. (1817 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1215 aa)
IGFBP1Insulin-like growth factor-binding protein 1. (249 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4 isoform X1. (1916 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (969 aa)
EPHB1Ephrin type-B receptor 1. (1014 aa)
INSRRTyrosine-protein kinase receptor. (1364 aa)
CRB1Protein crumbs homolog 1. (1378 aa)
CD93Complement component C1q receptor. (649 aa)
SLIT3Slit homolog 3 protein. (1372 aa)
RSPO1R-spondin-1. (265 aa)
UMODUromodulin. (679 aa)
CRTAC1Cartilage acidic protein 1. (726 aa)
EPHB4Ephrin type-B receptor 4. (987 aa)
CRELD1Cysteine-rich with EGF-like domain protein 1. (420 aa)
SCARF2LOW QUALITY PROTEIN: scavenger receptor class F member 2. (619 aa)
FBLN5Fibulin-5. (451 aa)
FRAS1Extracellular matrix protein FRAS1. (4066 aa)
EGFL8Epidermal growth factor-like protein 8 isoform X2. (338 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2741 aa)
GPSM3Neurogenic locus notch homolog protein 4 isoform X1. (162 aa)
CRELD2Cysteine-rich with EGF-like domain protein 2. (568 aa)
HTRA3Serine protease HTRA3. (419 aa)
DNERDelta and Notch-like epidermal growth factor-related receptor. (650 aa)
EPHB2Ephrin type-B receptor 2 isoform X3. (963 aa)
EGFL7Epidermal growth factor-like protein 7. (305 aa)
SCUBE3Signal peptide, CUB and EGF-like domain-containing protein 3. (982 aa)
TNFRSF9Tumor necrosis factor receptor superfamily member 9 isoform X2. (246 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2644 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1883 aa)
ADGRE5CD97 antigen isoform X1; Belongs to the G-protein coupled receptor 2 family. (994 aa)
FBN3Fibrillin-3 isoform X2. (2847 aa)
LOC112908104Adhesion G protein-coupled receptor E2-like isoform X1; Belongs to the G-protein coupled receptor 2 family. (804 aa)
CD248Endosialin. (772 aa)
EFEMP2EGF-containing fibulin-like extracellular matrix protein 2. (472 aa)
MEGF6Multiple epidermal growth factor-like domains protein 6. (1540 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3 isoform X3. (1204 aa)
CCN2Connective tissue growth factor. (464 aa)
TMEM67Meckelin. (991 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5 isoform X3; Belongs to the peptidase S8 family. (913 aa)
SUSD1Sushi domain-containing protein 1. (718 aa)
KIAA1324LUPF0577 protein KIAA1324-like homolog. (983 aa)
ERBB2Receptor protein-tyrosine kinase. (1266 aa)
SCUBE2Signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1. (1103 aa)
IGFBP6Insulin-like growth factor-binding protein 6. (238 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (698 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1. (3409 aa)
EPHA2Ephrin type-A receptor 2. (921 aa)
FBN2Fibrillin-2. (2757 aa)
LAMA2Laminin subunit alpha-2. (3017 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2755 aa)
RSPO3R-spondin-3 isoform X1. (279 aa)
KIAA1324UPF0577 protein KIAA1324 homolog isoform X2. (1020 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
KAZALD1Kazal-type serine protease inhibitor domain-containing protein 1. (302 aa)
SCUBE1Signal peptide, CUB and EGF-like domain-containing protein 1. (972 aa)
VLDLRVery low-density lipoprotein receptor. (868 aa)
FURINFurin; Belongs to the peptidase S8 family. (793 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (271 aa)
CCN5WNT1-inducible-signaling pathway protein 2. (444 aa)
RSPO4R-spondin-4. (371 aa)
EGFL6Epidermal growth factor-like protein 6. (606 aa)
EYSProtein eyes shut homolog. (2516 aa)
ERBB4Receptor protein-tyrosine kinase. (1249 aa)
NID1Nidogen-1. (1244 aa)
CRB2Protein crumbs homolog 2. (1012 aa)
HMCN1Hemicentin-1. (4698 aa)
EGFRReceptor protein-tyrosine kinase. (1154 aa)
NELL1Protein kinase C-binding protein NELL1. (781 aa)
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1. (502 aa)
MATN2Matrilin-2 isoform X1. (943 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X7. (1406 aa)
FAT1Protocadherin Fat 1 isoform X3. (4614 aa)
EPHB3Ephrin type-B receptor 3. (959 aa)
BRINP3BMP/retinoic acid-inducible neural-specific protein 3. (766 aa)
GAS6Growth arrest-specific protein 6. (655 aa)
FAT4Protocadherin Fat 4. (4982 aa)
EPHA7Ephrin type-A receptor 7 isoform X1. (998 aa)
IGF1RTyrosine-protein kinase receptor. (1249 aa)
ESM1Endothelial cell-specific molecule 1. (184 aa)
NPNTNephronectin. (601 aa)
RSPO2R-spondin-2. (243 aa)
NELL2Protein kinase C-binding protein NELL2. (816 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4329 aa)
EPHA1Ephrin type-A receptor 1. (946 aa)
VWDEVon Willebrand factor D and EGF domain-containing protein isoform X1. (1770 aa)
FBN1Fibrillin-1. (2881 aa)
ADGRE1Adhesion G protein-coupled receptor E1; Belongs to the G-protein coupled receptor 2 family. (1113 aa)
CCN3Protein NOV homolog. (383 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
MATN3Matrilin-3. (396 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (910 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2471 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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