44 items (Vulpes vulpes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP21A2	Steroid 21-hydroxylase isoform X4; Belongs to the cytochrome P450 family. (492 aa)
	LOC112914181	Cytochrome P450 2K6-like; Belongs to the cytochrome P450 family. (422 aa)
	CYP2W1	Cytochrome P450 2W1 isoform X2; Belongs to the cytochrome P450 family. (497 aa)
	CYP46A1	Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family. (500 aa)
	CYP2J2	Cytochrome P450 2J2; Belongs to the cytochrome P450 family. (446 aa)
	CYP2E1	Cytochrome P450 2E1; Belongs to the cytochrome P450 family. (523 aa)
	LOC112928780	Cytochrome P450 2C23-like isoform X1; Belongs to the cytochrome P450 family. (496 aa)
	CYP2R1	Vitamin D 25-hydroxylase; Belongs to the cytochrome P450 family. (501 aa)
	LOC112935745	Cytochrome P450 3A12-like. (503 aa)
	LOC112917654	Cytochrome P450 2C21; Belongs to the cytochrome P450 family. (490 aa)
	LOC112917651	Cytochrome P450 2C41; Belongs to the cytochrome P450 family. (489 aa)
	LOC112935742	Cytochrome P450 3A12-like isoform X2. (548 aa)
	CYP24A1	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (478 aa)
	LOC112911200	Cytochrome P450 11B1, mitochondrial isoform X1; Belongs to the cytochrome P450 family. (602 aa)
	CYP26A1	LOW QUALITY PROTEIN: cytochrome P450 26A1; Belongs to the cytochrome P450 family. (495 aa)
	CYP26C1	Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (522 aa)
	CYP4F22	Cytochrome P450 4F22; Belongs to the cytochrome P450 family. (530 aa)
	CYP4F8	Cytochrome P450 4F6-like isoform X1; Belongs to the cytochrome P450 family. (520 aa)
	CYP1B1	Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
	CYP19A1	Aromatase; Belongs to the cytochrome P450 family. (503 aa)
	CYP1A2	Cytochrome P450 1A2 isoform X2; Belongs to the cytochrome P450 family. (512 aa)
	CYP1A1	Cytochrome P450 1A1; Belongs to the cytochrome P450 family. (524 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (551 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
	CYP2U1	Cytochrome P450 2U1; Belongs to the cytochrome P450 family. (335 aa)
	CYP27B1	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
	CYP51A1	Lanosterol 14-alpha demethylase isoform X1; Belongs to the cytochrome P450 family. (511 aa)
	CYP4V2	Cytochrome P450 4V2; Belongs to the cytochrome P450 family. (597 aa)
	CYP27C1	Cytochrome P450 27C1 isoform X2; Belongs to the cytochrome P450 family. (492 aa)
	CYP26B1	Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (561 aa)
	CYP4B1	Cytochrome P450 4B1 isoform X1; Belongs to the cytochrome P450 family. (511 aa)
	LOC112914751	Cytochrome P450 4A6-like; Belongs to the cytochrome P450 family. (510 aa)
	LOC112914749	Cytochrome P450 4A11-like; Belongs to the cytochrome P450 family. (510 aa)
	CYP4X1	Cytochrome P450 4X1-like; Belongs to the cytochrome P450 family. (507 aa)
	LOC112928355	Cytochrome P450 2A13; Belongs to the cytochrome P450 family. (528 aa)
	LOC112928291	Cytochrome P450 2A13-like; Belongs to the cytochrome P450 family. (473 aa)
	LOC112928569	Cytochrome P450 2G1; Belongs to the cytochrome P450 family. (494 aa)
	CYP2B6	Cytochrome P450 2B11; Belongs to the cytochrome P450 family. (524 aa)
	LOC112928567	Cytochrome P450 2S1-like; Belongs to the cytochrome P450 family. (164 aa)
	CYP27A1	Sterol 26-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (530 aa)
	TBXAS1	thromboxane-A synthase; Belongs to the cytochrome P450 family. (533 aa)
	LOC112934002	Cytochrome P450 2D15 isoform X2; Belongs to the cytochrome P450 family. (493 aa)
	LOC112912763	Cytochrome P450 4A11-like; Belongs to the cytochrome P450 family. (500 aa)
	CYP17A1	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (508 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP11A1	CYP17A1	ENSVVUP00000025286	ENSVVUP00000005426	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	0.947
CYP11A1	CYP19A1	ENSVVUP00000025286	ENSVVUP00000025542	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Aromatase; Belongs to the cytochrome P450 family.	0.412
CYP11A1	CYP1A1	ENSVVUP00000025286	ENSVVUP00000025386	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 1A1; Belongs to the cytochrome P450 family.	0.402
CYP11A1	CYP1A2	ENSVVUP00000025286	ENSVVUP00000025389	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 1A2 isoform X2; Belongs to the cytochrome P450 family.	0.403
CYP11A1	CYP21A2	ENSVVUP00000025286	ENSVVUP00000034372	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Steroid 21-hydroxylase isoform X4; Belongs to the cytochrome P450 family.	0.444
CYP11A1	CYP26C1	ENSVVUP00000025286	ENSVVUP00000029862	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 26C1; Belongs to the cytochrome P450 family.	0.542
CYP11A1	CYP46A1	ENSVVUP00000025286	ENSVVUP00000039839	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cholesterol 24-hydroxylase; Belongs to the cytochrome P450 family.	0.433
CYP11A1	LOC112928567	ENSVVUP00000025286	ENSVVUP00000007119	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 2S1-like; Belongs to the cytochrome P450 family.	0.568
CYP11A1	LOC112934002	ENSVVUP00000025286	ENSVVUP00000003159	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	Cytochrome P450 2D15 isoform X2; Belongs to the cytochrome P450 family.	0.543
CYP17A1	CYP11A1	ENSVVUP00000005426	ENSVVUP00000025286	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]	0.947
CYP17A1	CYP19A1	ENSVVUP00000005426	ENSVVUP00000025542	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Aromatase; Belongs to the cytochrome P450 family.	0.942
CYP17A1	CYP1A1	ENSVVUP00000005426	ENSVVUP00000025386	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cytochrome P450 1A1; Belongs to the cytochrome P450 family.	0.914
CYP17A1	CYP1A2	ENSVVUP00000005426	ENSVVUP00000025389	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cytochrome P450 1A2 isoform X2; Belongs to the cytochrome P450 family.	0.914
CYP17A1	CYP24A1	ENSVVUP00000005426	ENSVVUP00000031195	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family.	0.405
CYP17A1	CYP2B6	ENSVVUP00000005426	ENSVVUP00000007125	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cytochrome P450 2B11; Belongs to the cytochrome P450 family.	0.919
CYP17A1	CYP2E1	ENSVVUP00000005426	ENSVVUP00000036331	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cytochrome P450 2E1; Belongs to the cytochrome P450 family.	0.919
CYP17A1	CYP7A1	ENSVVUP00000005426	ENSVVUP00000024435	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.949
CYP17A1	LOC112911200	ENSVVUP00000005426	ENSVVUP00000031109	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cytochrome P450 11B1, mitochondrial isoform X1; Belongs to the cytochrome P450 family.	0.724
CYP17A1	LOC112917651	ENSVVUP00000005426	ENSVVUP00000031332	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cytochrome P450 2C41; Belongs to the cytochrome P450 family.	0.918
CYP17A1	LOC112917654	ENSVVUP00000005426	ENSVVUP00000031335	Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family.	Cytochrome P450 2C21; Belongs to the cytochrome P450 family.	0.917