(7 nodes) Insulin-like superfamily network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	INSL3	Insulin-like 3. (144 aa)
	IGF1	Insulin-like growth factor I isoform X1. (187 aa)
	IGF2	Insulin-like growth factor II isoform X2. (238 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	INSL6	Insulin-like peptide INSL6. (212 aa)
	LOC112922149	Prorelaxin isoform X2. (177 aa)
	RLN3	Relaxin-3. (172 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IGF1	IGF2	ENSVVUP00000024480	ENSVVUP00000003420	Insulin-like growth factor I isoform X1.	Insulin-like growth factor II isoform X2.	0.960
IGF1	INS	ENSVVUP00000024480	ENSVVUP00000003455	Insulin-like growth factor I isoform X1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.980
IGF2	IGF1	ENSVVUP00000003420	ENSVVUP00000024480	Insulin-like growth factor II isoform X2.	Insulin-like growth factor I isoform X1.	0.960
IGF2	INS	ENSVVUP00000003420	ENSVVUP00000003455	Insulin-like growth factor II isoform X2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.725
INS	IGF1	ENSVVUP00000003455	ENSVVUP00000024480	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor I isoform X1.	0.980
INS	IGF2	ENSVVUP00000003455	ENSVVUP00000003420	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like growth factor II isoform X2.	0.725
INS	INSL3	ENSVVUP00000003455	ENSVVUP00000014004	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin-like 3.	0.502
INS	LOC112922149	ENSVVUP00000003455	ENSVVUP00000009949	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Prorelaxin isoform X2.	0.437
INSL3	INS	ENSVVUP00000014004	ENSVVUP00000003455	Insulin-like 3.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.502
INSL3	INSL6	ENSVVUP00000014004	ENSVVUP00000009907	Insulin-like 3.	Insulin-like peptide INSL6.	0.557
INSL3	LOC112922149	ENSVVUP00000014004	ENSVVUP00000009949	Insulin-like 3.	Prorelaxin isoform X2.	0.986
INSL3	RLN3	ENSVVUP00000014004	ENSVVUP00000037423	Insulin-like 3.	Relaxin-3.	0.935
INSL6	INSL3	ENSVVUP00000009907	ENSVVUP00000014004	Insulin-like peptide INSL6.	Insulin-like 3.	0.557
INSL6	LOC112922149	ENSVVUP00000009907	ENSVVUP00000009949	Insulin-like peptide INSL6.	Prorelaxin isoform X2.	0.536
INSL6	RLN3	ENSVVUP00000009907	ENSVVUP00000037423	Insulin-like peptide INSL6.	Relaxin-3.	0.607
LOC112922149	INS	ENSVVUP00000009949	ENSVVUP00000003455	Prorelaxin isoform X2.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.437
LOC112922149	INSL3	ENSVVUP00000009949	ENSVVUP00000014004	Prorelaxin isoform X2.	Insulin-like 3.	0.986
LOC112922149	INSL6	ENSVVUP00000009949	ENSVVUP00000009907	Prorelaxin isoform X2.	Insulin-like peptide INSL6.	0.536
LOC112922149	RLN3	ENSVVUP00000009949	ENSVVUP00000037423	Prorelaxin isoform X2.	Relaxin-3.	0.986
RLN3	INSL3	ENSVVUP00000037423	ENSVVUP00000014004	Relaxin-3.	Insulin-like 3.	0.935