STRINGSTRING
SGK1 SGK1 SH3GL2 SH3GL2 AP2S1 AP2S1 AP2A2 AP2A2 TRIB2 TRIB2 BRAF BRAF FNDC3B FNDC3B SHC1 SHC1 PCSK5 PCSK5 MAPKAPK2 MAPKAPK2 ASCL2 ASCL2 ENSVVUP00000004646 ENSVVUP00000004646 FOSB FOSB ENSVVUP00000005393 ENSVVUP00000005393 PTPRO PTPRO PIK3CA PIK3CA EGR3 EGR3 EGR4 EGR4 RALA RALA RIT1 RIT1 ENSVVUP00000008059 ENSVVUP00000008059 NTRK1 NTRK1 FURIN FURIN PIK3R1 PIK3R1 FYN FYN AP2M1 AP2M1 LOC112931200 LOC112931200 MAP2K2 MAP2K2 KIDINS220 KIDINS220 ID2 ID2 EGR2 EGR2 PIK3R2 PIK3R2 NRAS NRAS CSDE1 CSDE1 FRS2 FRS2 AP2M1-2 AP2M1-2 PPP2R1A PPP2R1A RRAD RRAD GRB2 GRB2 CHD4 CHD4 DUSP6 DUSP6 PPP4R1 PPP4R1 CREB1 CREB1 RPS6KA1 RPS6KA1 NTRK3 NTRK3 ENSVVUP00000017517 ENSVVUP00000017517 RPS6KA3 RPS6KA3 ARC ARC MAP2K1 MAP2K1 PCSK6 PCSK6 MAP2K5 MAP2K5 SRMS SRMS PPP2R1B PPP2R1B RAP1A RAP1A SHC4 SHC4 TRIB1 TRIB1 LOC112932177 LOC112932177 HRAS HRAS DUSP3 DUSP3 ELK1 ELK1 RELCH RELCH NTF3 NTF3 ERAS ERAS ENSVVUP00000024290 ENSVVUP00000024290 CLTC CLTC ASCL1 ASCL1 EGR1 EGR1 RPS6KA5 RPS6KA5 RALB RALB SOS1 SOS1 PPP4R4 PPP4R4 YWHAB YWHAB NAB2 NAB2 DUSP4 DUSP4 PPP2CB PPP2CB CLTA CLTA VRK3 VRK3 AP2B1 AP2B1 MAPK1 MAPK1 IRS2 IRS2 ENSVVUP00000029104 ENSVVUP00000029104 AP2A1 AP2A1 CRKL CRKL PPP2CA PPP2CA CRK CRK RPS6KA2 RPS6KA2 ENSVVUP00000030530 ENSVVUP00000030530 SHC3 SHC3 SHC2 SHC2 MAPK15 MAPK15 NTRK2 NTRK2 DNAL4 DNAL4 PCSK4 PCSK4 NTF4 NTF4 FNBP4 FNBP4 JUNB JUNB LYL1 LYL1 MAPK11 MAPK11 IRS1 IRS1 ATF1 ATF1 MAPK3 MAPK3 MAPK14 MAPK14 PIK3CB PIK3CB DUSP7 DUSP7 ID3 ID3 FOSL1 FOSL1 NAB1 NAB1 PPP2R5D PPP2R5D RIT2 RIT2 DOCK3 DOCK3 FNDC3A FNDC3A RAPGEF1 RAPGEF1 MAPKAPK3 MAPKAPK3 RALGDS RALGDS SRF SRF PLCG1 PLCG1 SRC SRC RPS6KA4 RPS6KA4 MAPK7 MAPK7 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SGK1Non-specific serine/threonine protein kinase. (526 aa)
SH3GL2endophilin-A1. (341 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (164 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (935 aa)
TRIB2Tribbles homolog 2. (435 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (765 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1220 aa)
SHC1SHC-transforming protein 1 isoform X1. (583 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5 isoform X3; Belongs to the peptidase S8 family. (913 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (429 aa)
ASCL2Achaete-scute homolog 2. (197 aa)
ENSVVUP00000004646annotation not available (112 aa)
FOSBProtein fosB isoform X1. (418 aa)
ENSVVUP00000005393annotation not available (155 aa)
PTPROReceptor-type tyrosine-protein phosphatase O isoform X1. (1233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EGR3Early growth response protein 3 isoform X3. (349 aa)
EGR4Early growth response protein 4 isoform X1. (589 aa)
RALARas-related protein Ral-A. (206 aa)
RIT1GTP-binding protein Rit1 isoform X2. (219 aa)
ENSVVUP00000008059annotation not available (559 aa)
NTRK1Tyrosine-protein kinase receptor. (967 aa)
FURINFurin; Belongs to the peptidase S8 family. (793 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FYNTyrosine-protein kinase. (537 aa)
AP2M1AP-2 complex subunit mu-1. (357 aa)
LOC112931200LOW QUALITY PROTEIN: NTPase KAP family P-loop domain-containing protein 1-like. (721 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (398 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X5. (1782 aa)
ID2DNA-binding protein inhibitor ID-2. (196 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (485 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (735 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X3. (731 aa)
FRS2Fibroblast growth factor receptor substrate 2 isoform X1. (508 aa)
AP2M1-2AP-2 complex subunit mu; Belongs to the adaptor complexes medium subunit family. (435 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
RRADGTP-binding protein RAD. (278 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X3. (1984 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (906 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NTRK3NT-3 growth factor receptor isoform X1. (596 aa)
ENSVVUP00000017517annotation not available (118 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
MAP2K1Mitogen-activated protein kinase kinase 1. (444 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (910 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X2; Belongs to the protein kinase superfamily. (486 aa)
SRMSTyrosine-protein kinase. (885 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (656 aa)
RAP1ARas-related protein Rap-1A. (336 aa)
SHC4SHC-transforming protein 4. (631 aa)
TRIB1Tribbles homolog 1. (141 aa)
LOC112932177Serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1. (971 aa)
HRASGTPase HRas isoform X1. (189 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X3. (1212 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (352 aa)
ERASGTPase ERas. (228 aa)
ENSVVUP00000024290annotation not available (257 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1536 aa)
ASCL1Achaete-scute homolog 1. (211 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
RPS6KA5Ribosomal protein S6 kinase. (913 aa)
RALBRas-related protein Ral-B. (206 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (864 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
NAB2NGFI-A-binding protein 2 isoform X1. (525 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (435 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X2. (458 aa)
AP2B1AP complex subunit beta. (958 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
IRS2LOW QUALITY PROTEIN: insulin receptor substrate 2. (1423 aa)
ENSVVUP00000029104annotation not available (140 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
CRKLCrk-like protein. (303 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CRKAdapter molecule crk isoform X1. (285 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
ENSVVUP00000030530annotation not available (121 aa)
SHC3SHC-transforming protein 3. (289 aa)
SHC2SHC-transforming protein 2 isoform X1. (108 aa)
MAPK15Mitogen-activated protein kinase. (601 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
DNAL4Dynein light chain. (68 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4 isoform X7; Belongs to the peptidase S8 family. (802 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
FNBP4LOW QUALITY PROTEIN: formin-binding protein 4. (1022 aa)
JUNBTranscription factor jun-B. (347 aa)
LYL1Protein lyl-1. (273 aa)
MAPK11Mitogen-activated protein kinase. (332 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X2. (270 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (464 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
FOSL1Fos-related antigen 1 isoform X1. (268 aa)
NAB1LOW QUALITY PROTEIN: NGFI-A-binding protein 1. (409 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (604 aa)
RIT2GTP-binding protein Rit2. (83 aa)
DOCK3Dedicator of cytokinesis protein 3; Belongs to the DOCK family. (2069 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X3. (1240 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X4. (892 aa)
SRFSerum response factor isoform X1. (508 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
SRCTyrosine-protein kinase. (536 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (709 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
KRASGTPase KRas isoform X1. (418 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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