STRINGSTRING
PELI2 PELI2 IKBKG IKBKG KHNYN KHNYN ENSVVUP00000040094 ENSVVUP00000040094 MAPKAPK3 MAPKAPK3 S100A12 S100A12 NKIRAS1 NKIRAS1 ATF7 ATF7 PPP2R5D PPP2R5D RELA RELA MAP2K7 MAP2K7 PELI3 PELI3 MAPK9 MAPK9 DUSP7 DUSP7 ENSVVUP00000037430 ENSVVUP00000037430 MAPK14 MAPK14 TRAF2 TRAF2 MAPK3 MAPK3 ATF1 ATF1 UBC UBC MAPK11 MAPK11 AGER AGER CHUK CHUK CREB5 CREB5 LOC112910913 LOC112910913 APP APP TNIP2 TNIP2 ECSIT ECSIT IRAK2 IRAK2 CPNE2 CPNE2 FNBP4 FNBP4 NLRX1 NLRX1 USP18 USP18 MAPK15 MAPK15 LOC112917600 LOC112917600 UBE2V1 UBE2V1 LRRC74B LRRC74B RPS6KA2 RPS6KA2 ENSVVUP00000029422 ENSVVUP00000029422 MAP3K1 MAP3K1 PPP2CA PPP2CA NOD1 NOD1 MAPK8 MAPK8 NKIRAS2 NKIRAS2 S100B S100B MAPK1 MAPK1 VRK3 VRK3 ENSVVUP00000027292 ENSVVUP00000027292 NFKBIA NFKBIA ENSVVUP00000027142 ENSVVUP00000027142 PPP2CB PPP2CB DUSP4 DUSP4 NOD2 NOD2 CASP8 CASP8 PPP4R4 PPP4R4 RPS6KA5 RPS6KA5 ENSVVUP00000024657 ENSVVUP00000024657 N4BP1 N4BP1 ENSVVUP00000024290 ENSVVUP00000024290 RELCH RELCH ENSVVUP00000023942 ENSVVUP00000023942 ELK1 ELK1 DUSP3 DUSP3 ENSVVUP00000023416 ENSVVUP00000023416 LOC112932177 LOC112932177 NLRP6 NLRP6 PPP2R1B PPP2R1B TAB1 TAB1 MAP3K7 MAP3K7 MAP3K20 MAP3K20 MAP3K20-2 MAP3K20-2 MAPK10 MAPK10 LOC112932868 LOC112932868 RPS6KA3 RPS6KA3 ENSVVUP00000017517 ENSVVUP00000017517 ATF2 ATF2 PELI1 PELI1 RPS6KA1 RPS6KA1 CREB1 CREB1 PPP4R1 PPP4R1 ENSVVUP00000016091 ENSVVUP00000016091 DUSP6 DUSP6 PPP2R1A PPP2R1A ENSVVUP00000014764 ENSVVUP00000014764 ENSVVUP00000014079 ENSVVUP00000014079 RPS27A RPS27A HMGB1 HMGB1 MAP2K6 MAP2K6 NFKB1 NFKB1 VWC2L VWC2L NFKBIB NFKBIB NLRP13 NLRP13 NLRP9 NLRP9 TRAF6 TRAF6 LOC112928967 LOC112928967 TAB3 TAB3 IKBKB IKBKB LRRC34 LRRC34 LRRC31 LRRC31 LRRC45 LRRC45 FOSL2 FOSL2 RIPK2 RIPK2 TIFA TIFA ALPK1 ALPK1 MAPKAPK2 MAPKAPK2 LRRC74A LRRC74A NFKB2 NFKB2 ENSVVUP00000005393 ENSVVUP00000005393 USP14 USP14 TAB2 TAB2 LOC112925668 LOC112925668 LRRC14 LRRC14 FOS FOS TONSL TONSL ENSVVUP00000007999 ENSVVUP00000007999 LOC112921655 LOC112921655 LRRC71 LRRC71 UBA52 UBA52 MAP2K3 MAP2K3 MAPK7 MAPK7 MAP2K4 MAP2K4 RPS6KA4 RPS6KA4 IRAK1 IRAK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
KHNYNProtein KHNYN. (669 aa)
ENSVVUP00000040094annotation not available (128 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
S100A12Protein S100; Belongs to the S-100 family. (110 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1. (206 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7 isoform X1. (483 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (604 aa)
RELATranscription factor p65 isoform X2. (542 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X2. (439 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (464 aa)
ENSVVUP00000037430annotation not available (99 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (533 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X2. (270 aa)
UBCpolyubiquitin-C. (190 aa)
MAPK11Mitogen-activated protein kinase. (332 aa)
AGERAdvanced glycosylation end product-specific receptor. (405 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (548 aa)
LOC112910913Ubiquitin-like. (77 aa)
APPAmyloid-beta A4 protein isoform X1. (770 aa)
TNIP2TNFAIP3-interacting protein 2 isoform X1. (435 aa)
ECSITEvolutionarily conserved signaling intermediate in Toll pathway, mitochondrial. (433 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (598 aa)
CPNE2Protein NLRC5. (1868 aa)
FNBP4LOW QUALITY PROTEIN: formin-binding protein 4. (1022 aa)
NLRX1NLR family member X1 isoform X1. (975 aa)
USP18Ubl carboxyl-terminal hydrolase 18 isoform X1; Belongs to the peptidase C19 family. (339 aa)
MAPK15Mitogen-activated protein kinase. (601 aa)
LOC112917600Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
UBE2V1Ubiquitin-conjugating enzyme E2 variant 1 isoform X3. (105 aa)
LRRC74BLeucine-rich repeat-containing protein 74B. (396 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
ENSVVUP00000029422Ubiquitin-conjugating enzyme E2 N-like. (89 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1397 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2. (209 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X2. (458 aa)
ENSVVUP00000027292Ubiquitin-conjugating enzyme E2 N-like. (146 aa)
NFKBIANF-kappa-B inhibitor alpha. (327 aa)
ENSVVUP00000027142annotation not available (182 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (435 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1043 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (397 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (864 aa)
RPS6KA5Ribosomal protein S6 kinase. (913 aa)
ENSVVUP00000024657annotation not available (103 aa)
N4BP1NEDD4-binding protein 1. (1009 aa)
ENSVVUP00000024290annotation not available (257 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X3. (1212 aa)
ENSVVUP00000023942Ubiquitin-conjugating enzyme E2 N-like. (93 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
ENSVVUP00000023416Ubiquitin-conjugating enzyme E2 N-like. (105 aa)
LOC112932177Serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1. (971 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (875 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (656 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (502 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X1. (509 aa)
MAP3K20-2Mitogen-activated protein kinase kinase kinase 20 isoform X2. (487 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
LOC112932868Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ENSVVUP00000017517annotation not available (118 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (906 aa)
ENSVVUP00000016091annotation not available (109 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
ENSVVUP00000014764annotation not available (139 aa)
ENSVVUP00000014079annotation not available (196 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
HMGB1High mobility group protein B1. (215 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
VWC2LVon Willebrand factor C domain-containing protein 2-like. (222 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
NLRP13NACHT, LRR and PYD domains-containing protein 13-like. (1029 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9. (995 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LOC112928967Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1. (717 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (782 aa)
LRRC34Leucine-rich repeat-containing protein 34. (402 aa)
LRRC31Leucine-rich repeat-containing protein 31 isoform X1. (457 aa)
LRRC45Leucine-rich repeat-containing protein 45. (670 aa)
FOSL2Fos-related antigen 2. (325 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TIFATRAF-interacting protein with FHA domain-containing protein A. (163 aa)
ALPK1Alpha-protein kinase 1 isoform X1. (1237 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (429 aa)
LRRC74ALeucine-rich repeat-containing protein 74A. (489 aa)
NFKB2LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit. (863 aa)
ENSVVUP00000005393annotation not available (155 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (545 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
LOC112925668High mobility group protein B1-like. (207 aa)
LRRC14Leucine-rich repeat-containing protein 14 isoform X1. (492 aa)
FOSProto-oncogene c-Fos. (380 aa)
TONSLTonsoku-like protein. (1165 aa)
ENSVVUP00000007999annotation not available (96 aa)
LOC112921655Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LRRC71Leucine-rich repeat-containing protein 71. (536 aa)
UBA52ubiquitin-60S ribosomal protein L40. (231 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (397 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (455 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (709 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (551 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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