STRINGSTRING
ICOS ICOS LOC112912664 LOC112912664 LOC112912663 LOC112912663 FNDC3B FNDC3B MAP3K8 MAP3K8 RICTOR RICTOR AKT1 AKT1 LOC112926139 LOC112926139 ENSVVUP00000005393 ENSVVUP00000005393 YES1 YES1 PIK3CA PIK3CA ENSVVUP00000007132 ENSVVUP00000007132 AKT2 AKT2 PIK3R1 PIK3R1 FYN FYN GRAP2 GRAP2 LOC112914774 LOC112914774 CD274 CD274 PDCD1LG2 PDCD1LG2 PPP2R5A PPP2R5A TRIB3 TRIB3 PAK2 PAK2 PDPK1 PDPK1 PIK3R2 PIK3R2 MLST8 MLST8 MAPKAP1 MAPKAP1 PTPN11 PTPN11 PAK3 PAK3 PTPN6 PTPN6 PPP2R1A PPP2R1A CD4 CD4 GRB2 GRB2 PPP4R1 PPP4R1 THEM4 THEM4 ENSVVUP00000019958 ENSVVUP00000019958 SRMS SRMS LCK LCK PPP2R1B PPP2R1B ENSVVUP00000023156 ENSVVUP00000023156 CTLA4 CTLA4 CD28 CD28 LOC112932177 LOC112932177 RELCH RELCH LYN LYN MAP3K14 MAP3K14 CD276 CD276 CSK CSK PPP4R4 PPP4R4 ENSVVUP00000026908 ENSVVUP00000026908 PPP2CB PPP2CB VAV1 VAV1 PPP2CA PPP2CA BTLA BTLA CD80 CD80 CD86 CD86 PDCD1 PDCD1 FNBP4 FNBP4 PAK1 PAK1 ICOSLG ICOSLG CD3G CD3G CD3D CD3D CD3E CD3E ENSVVUP00000034029 ENSVVUP00000034029 TRAV29DV5 TRAV29DV5 TRAV23DV6 TRAV23DV6 ENSVVUP00000034044 ENSVVUP00000034044 ENSVVUP00000034049 ENSVVUP00000034049 HLA-DRA HLA-DRA LOC112913648 LOC112913648 LOC112913861 LOC112913861 HLA-DPA1 HLA-DPA1 ENSVVUP00000034968 ENSVVUP00000034968 CD247 CD247 AKT3 AKT3 TNFRSF14 TNFRSF14 PPP2R5B PPP2R5B TRBV30 TRBV30 ENSVVUP00000038751 ENSVVUP00000038751 ENSVVUP00000038760 ENSVVUP00000038760 ENSVVUP00000038761 ENSVVUP00000038761 TRBV25-1 TRBV25-1 ENSVVUP00000038765 ENSVVUP00000038765 ENSVVUP00000038768 ENSVVUP00000038768 ENSVVUP00000038772 ENSVVUP00000038772 ENSVVUP00000038773 ENSVVUP00000038773 ENSVVUP00000038776 ENSVVUP00000038776 ENSVVUP00000038779 ENSVVUP00000038779 ENSVVUP00000038781 ENSVVUP00000038781 ENSVVUP00000038785 ENSVVUP00000038785 ENSVVUP00000038788 ENSVVUP00000038788 ENSVVUP00000038789 ENSVVUP00000038789 ENSVVUP00000038791 ENSVVUP00000038791 PPP2R5D PPP2R5D FNDC3A FNDC3A MTOR MTOR PPP2R5C PPP2R5C PRR5 PRR5 ENSVVUP00000040442 ENSVVUP00000040442 SRC SRC PPP2R5E PPP2R5E CDC42 CDC42
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ICOSInducible T-cell costimulator. (208 aa)
LOC112912664SLA class II histocompatibility antigen, DQ haplotype C beta chain-like. (313 aa)
LOC112912663HLA class II histocompatibility antigen, DQ alpha 2 chain-like; Belongs to the MHC class II family. (255 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1220 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1684 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC112926139Tyrosine-protein phosphatase non-receptor type 11-like. (612 aa)
ENSVVUP00000005393annotation not available (155 aa)
YES1Tyrosine-protein kinase. (541 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSVVUP00000007132annotation not available (147 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FYNTyrosine-protein kinase. (537 aa)
GRAP2GRB2-related adapter protein 2. (386 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
CD274Programmed cell death 1 ligand 1. (293 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (329 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (493 aa)
TRIB3Tribbles homolog 3. (358 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (735 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (587 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
PAK3Non-specific serine/threonine protein kinase. (547 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (636 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (906 aa)
THEM4Acyl-coenzyme A thioesterase THEM4. (237 aa)
ENSVVUP00000019958annotation not available (191 aa)
SRMSTyrosine-protein kinase. (885 aa)
LCKTyrosine-protein kinase. (249 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (656 aa)
ENSVVUP00000023156annotation not available (593 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
CD28T-cell-specific surface glycoprotein CD28. (217 aa)
LOC112932177Serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1. (971 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X3. (1212 aa)
LYNTyrosine-protein kinase. (512 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (1045 aa)
CD276CD276 antigen. (585 aa)
CSKTyrosine-protein kinase. (450 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (864 aa)
ENSVVUP00000026908annotation not available (155 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
VAV1Proto-oncogene vav. (846 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
BTLAB- and T-lymphocyte attenuator isoform X2. (253 aa)
CD80T-lymphocyte activation antigen CD80. (235 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (343 aa)
PDCD1Programmed cell death protein 1. (414 aa)
FNBP4LOW QUALITY PROTEIN: formin-binding protein 4. (1022 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ICOSLGICOS ligand isoform X1. (403 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (170 aa)
CD3DT-cell surface glycoprotein CD3 delta chain isoform X2. (180 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (198 aa)
ENSVVUP00000034029annotation not available (121 aa)
TRAV29DV5T cell receptor alpha variable 29/delta variable 5 (gene/pseudogene). (155 aa)
TRAV23DV6T cell receptor alpha variable 23/delta variable 6. (132 aa)
ENSVVUP00000034044annotation not available (129 aa)
ENSVVUP00000034049annotation not available (128 aa)
HLA-DRAHLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (265 aa)
LOC112913648DLA class II histocompatibility antigen, DR-1 beta chain. (287 aa)
LOC112913861SLA class II histocompatibility antigen, DQ haplotype C beta chain-like. (269 aa)
HLA-DPA1LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like; Belongs to the MHC class II family. (249 aa)
ENSVVUP00000034968annotation not available (145 aa)
CD247CD247 molecule. (176 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TNFRSF14Tumor necrosis factor receptor superfamily member 14 isoform X1. (272 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
TRBV30T cell receptor beta variable 30 (gene/pseudogene). (148 aa)
ENSVVUP00000038751annotation not available (284 aa)
ENSVVUP00000038760annotation not available (113 aa)
ENSVVUP00000038761annotation not available (113 aa)
TRBV25-1T cell receptor beta variable 25-1. (122 aa)
ENSVVUP00000038765annotation not available (146 aa)
ENSVVUP00000038768annotation not available (174 aa)
ENSVVUP00000038772annotation not available (146 aa)
ENSVVUP00000038773annotation not available (136 aa)
ENSVVUP00000038776annotation not available (200 aa)
ENSVVUP00000038779annotation not available (159 aa)
ENSVVUP00000038781annotation not available (156 aa)
ENSVVUP00000038785annotation not available (133 aa)
ENSVVUP00000038788annotation not available (135 aa)
ENSVVUP00000038789annotation not available (129 aa)
ENSVVUP00000038791annotation not available (145 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (604 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa)
PRR5Proline-rich protein 5. (401 aa)
ENSVVUP00000040442annotation not available (64 aa)
SRCTyrosine-protein kinase. (536 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (498 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.