(65 nodes) Smooth Muscle Contraction network (Vulpes vulpes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MYL9	Myosin regulatory light polypeptide 9. (172 aa)
	FER1L5	Fer-1-like protein 5. (2055 aa)
	ENSVVUP00000000476	annotation not available (169 aa)
	CALM3	Calmodulin-1; Belongs to the calmodulin family. (149 aa)
	ENSVVUP00000003877	annotation not available (140 aa)
	ENSVVUP00000005272	annotation not available (115 aa)
	MYLK	Myosin light chain kinase, smooth muscle isoform X1. (1998 aa)
	ENSVVUP00000005911	annotation not available (91 aa)
	TLNRD1	Talin rod domain-containing protein 1. (342 aa)
	SORBS3	Sorbin and SH3 domain containing 3. (944 aa)
	CALD1	Caldesmon isoform X4. (359 aa)
	LOC112920713	Tropomyosin alpha-4 chain; Belongs to the tropomyosin family. (333 aa)
	LMOD1	Leiomodin-1. (632 aa)
	DYSF	Dysferlin isoform X8. (2153 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (838 aa)
	PDE5A	Phosphodiesterase. (865 aa)
	MYL7	Myosin regulatory light chain 2, atrial isoform. (186 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	MYL12A	Myosin regulatory light polypeptide 9-like. (172 aa)
	MYL12B	Myosin regulatory light chain 12B. (180 aa)
	TTN	Titin isoform X6. (249 aa)
	ENSVVUP00000013506	annotation not available (540 aa)
	ENSVVUP00000013521	annotation not available (567 aa)
	TTN-2	Titin isoform X1. (571 aa)
	TTN-3	Titin isoform X5. (443 aa)
	TLN2	Talin-2 isoform X2. (2556 aa)
	ENSVVUP00000014596	annotation not available (181 aa)
	CACNA1G	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
	TPM1	Tropomyosin alpha-1 chain isoform X6. (342 aa)
	CACNA1H	Voltage-dependent T-type calcium channel subunit alpha-1H. (2324 aa)
	SORBS2	Sorbin and SH3 domain-containing protein 2 isoform X11. (1200 aa)
	MYL5	Myosin light chain 5. (174 aa)
	CACNA1I	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2127 aa)
	TPM1-2	Tropomyosin alpha-1 chain isoform X9. (258 aa)
	GUCY1A2	Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (694 aa)
	ENSVVUP00000019450	annotation not available (102 aa)
	TPM3-2	Tropomyosin alpha-3 chain isoform X8; Belongs to the tropomyosin family. (57 aa)
	ALDH2	Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. (538 aa)
	LPXN	Leupaxin isoform X1; Belongs to the paxillin family. (386 aa)
	CALM1	Calmodulin 1. (149 aa)
	MYH11	Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
	TPM4	Tropomyosin alpha-4 chain isoform X1; Belongs to the tropomyosin family. (284 aa)
	PXN	Paxillin. (1079 aa)
	MYL6	Myosin light polypeptide 6 isoform X2. (209 aa)
	MYL6B	Myosin light chain 6B. (192 aa)
	MYOF	Myoferlin isoform X2. (2124 aa)
	SORBS1	Sorbin and SH3 domain-containing protein 1 isoform X4. (921 aa)
	VCL	Vinculin isoform X2. (1134 aa)
	TLN1	Talin-1 isoform X1. (2562 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	MYL10	Myosin regulatory light chain 10. (206 aa)
	LOC112910844	Guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (719 aa)
	TPM2	Tropomyosin beta chain isoform X2; Belongs to the tropomyosin family. (290 aa)
	LOC112913093	Tropomyosin alpha-3 chain-like. (118 aa)
	GUCY1B1	Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (641 aa)
	GUCY1A1	Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	ITGA1	Integrin alpha-1; Belongs to the integrin alpha chain family. (1143 aa)
	SPEGNB	CAVP-target protein. (215 aa)
	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform. (200 aa)
	TRIM72	Tripartite motif-containing protein 72. (524 aa)
	RNF222	RING finger protein 222. (201 aa)
	TPM3	Tropomyosin alpha-3 chain isoform X1; Belongs to the tropomyosin family. (248 aa)
	ENSVVUP00000040096	annotation not available (89 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Belongs to the paxillin family. (447 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACNA1G	CACNA1H	ENSVVUP00000014678	ENSVVUP00000015441	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Voltage-dependent T-type calcium channel subunit alpha-1H.	0.515
CACNA1G	CACNA1I	ENSVVUP00000014678	ENSVVUP00000018695	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.923
CACNA1G	CALM3	ENSVVUP00000014678	ENSVVUP00000003523	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Calmodulin-1; Belongs to the calmodulin family.	0.915
CACNA1H	CACNA1G	ENSVVUP00000015441	ENSVVUP00000014678	Voltage-dependent T-type calcium channel subunit alpha-1H.	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.515
CACNA1H	CACNA1I	ENSVVUP00000015441	ENSVVUP00000018695	Voltage-dependent T-type calcium channel subunit alpha-1H.	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.561
CACNA1H	CAV3	ENSVVUP00000015441	ENSVVUP00000035215	Voltage-dependent T-type calcium channel subunit alpha-1H.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.517
CACNA1I	CACNA1G	ENSVVUP00000018695	ENSVVUP00000014678	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.923
CACNA1I	CACNA1H	ENSVVUP00000018695	ENSVVUP00000015441	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Voltage-dependent T-type calcium channel subunit alpha-1H.	0.561
CACNA1I	CALM3	ENSVVUP00000018695	ENSVVUP00000003523	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Calmodulin-1; Belongs to the calmodulin family.	0.915
CACNA1I	CAV3	ENSVVUP00000018695	ENSVVUP00000035215	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.450
CALD1	ENSVVUP00000005272	ENSVVUP00000007687	ENSVVUP00000005272	Caldesmon isoform X4.	annotation not available	0.808
CALD1	ITGA1	ENSVVUP00000007687	ENSVVUP00000035439	Caldesmon isoform X4.	Integrin alpha-1; Belongs to the integrin alpha chain family.	0.444
CALD1	ITGB5	ENSVVUP00000007687	ENSVVUP00000009702	Caldesmon isoform X4.	Integrin beta; Belongs to the integrin beta chain family.	0.442
CALD1	LMOD1	ENSVVUP00000007687	ENSVVUP00000008424	Caldesmon isoform X4.	Leiomodin-1.	0.739
CALD1	MYH11	ENSVVUP00000007687	ENSVVUP00000026698	Caldesmon isoform X4.	Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.808
CALD1	MYL10	ENSVVUP00000007687	ENSVVUP00000032669	Caldesmon isoform X4.	Myosin regulatory light chain 10.	0.469
CALD1	MYL5	ENSVVUP00000007687	ENSVVUP00000017540	Caldesmon isoform X4.	Myosin light chain 5.	0.469
CALD1	MYL6B	ENSVVUP00000007687	ENSVVUP00000030129	Caldesmon isoform X4.	Myosin light chain 6B.	0.465
CALD1	MYLPF	ENSVVUP00000007687	ENSVVUP00000036436	Caldesmon isoform X4.	Myosin regulatory light chain 2, skeletal muscle isoform.	0.469
CALD1	PXN	ENSVVUP00000007687	ENSVVUP00000028676	Caldesmon isoform X4.	Paxillin.	0.448