STRINGSTRING
IKBKB IKBKB LRRC34 LRRC34 LRRC31 LRRC31 PSMB2 PSMB2 BTRC BTRC LRRC45 LRRC45 PSMD3 PSMD3 SQSTM1 SQSTM1 TIFA TIFA ALPK1 ALPK1 TOLLIP TOLLIP PSMA8 PSMA8 PSMB3 PSMB3 PTPN5 PTPN5 ENSVVUP00000003182 ENSVVUP00000003182 PSMA5 PSMA5 LRRC74A LRRC74A PTPN23 PTPN23 NFKB2 NFKB2 ENSVVUP00000005276 ENSVVUP00000005276 LOC112923316 LOC112923316 ENSVVUP00000005490 ENSVVUP00000005490 USP14 USP14 LOC112919437 LOC112919437 TAB2 TAB2 LOC112925668 LOC112925668 LRRC14 LRRC14 MAP3K3 MAP3K3 TONSL TONSL PSMC4 PSMC4 ENSVVUP00000007999 ENSVVUP00000007999 PSMC5 PSMC5 LOC112921655 LOC112921655 MYD88 MYD88 LRRC71 LRRC71 NFKBIB NFKBIB PSMD12 PSMD12 PSMA2 PSMA2 NLRP13 NLRP13 NLRP9 NLRP9 RBX1 RBX1 PSMB1 PSMB1 TRAF6 TRAF6 LOC112928967 LOC112928967 ENSVVUP00000009448 ENSVVUP00000009448 ENSVVUP00000010304 ENSVVUP00000010304 TAB3 TAB3 PSME4 PSME4 PSMA4 PSMA4 UBA52 UBA52 PSMF1 PSMF1 PTPN14 PTPN14 VWC2L VWC2L NFKB1 NFKB1 ENSVVUP00000012574 ENSVVUP00000012574 MAP2K6 MAP2K6 HMGB1 HMGB1 PSMB7 PSMB7 RPS27A RPS27A PSMD10 PSMD10 ENSVVUP00000014079 ENSVVUP00000014079 MAP3K2 MAP3K2 ENSVVUP00000014607 ENSVVUP00000014607 ENSVVUP00000014764 ENSVVUP00000014764 IRAK3 IRAK3 ENSVVUP00000016091 ENSVVUP00000016091 ENSVVUP00000016245 ENSVVUP00000016245 PSMD5 PSMD5 PSMD2 PSMD2 IL1RAPL1 IL1RAPL1 PELI1 PELI1 PSMB10 PSMB10 IL18RAP IL18RAP IL18R1 IL18R1 IL1RL1 IL1RL1 IL1RL2 IL1RL2 PSMD4 PSMD4 IL1R1 IL1R1 IL1R2 IL1R2 PSMB4 PSMB4 ENSVVUP00000017628 ENSVVUP00000017628 PSMD8 PSMD8 LOC112932868 LOC112932868 IL1RAP IL1RAP MAP3K20-2 MAP3K20-2 MAP3K20 MAP3K20 MAP3K7 MAP3K7 TAB1 TAB1 SMAD3 SMAD3 PSMC2 PSMC2 PSMD6 PSMD6 TBK1 TBK1 PSMA7 PSMA7 IL18 IL18 CUL1 CUL1 PSMD13 PSMD13 NLRP6 NLRP6 IRAK4 IRAK4 SIGIRR SIGIRR ENSVVUP00000023416 ENSVVUP00000023416 PSMD7 PSMD7 ENSVVUP00000023942 ENSVVUP00000023942 N4BP1 N4BP1 ENSVVUP00000024657 ENSVVUP00000024657 PSMC1 PSMC1 PSMD14 PSMD14 CASP8 CASP8 PTPN9 PTPN9 ENSVVUP00000026875 ENSVVUP00000026875 PSMB5 PSMB5 PSMB11 PSMB11 ENSVVUP00000027142 ENSVVUP00000027142 PSMA6 PSMA6 NFKBIA NFKBIA ENSVVUP00000027292 ENSVVUP00000027292 IL33 IL33 ENSVVUP00000027737 ENSVVUP00000027737 S100B S100B PSMD11 PSMD11 PTPN20 PTPN20 NKIRAS2 NKIRAS2 SKP1 SKP1 ENSVVUP00000029422 ENSVVUP00000029422 LRRC74B LRRC74B ENSVVUP00000029975 ENSVVUP00000029975 ENSVVUP00000030237 ENSVVUP00000030237 UBE2V1 UBE2V1 LOC112917600 LOC112917600 MFSD1 MFSD1 GSDMD GSDMD USP18 USP18 NLRX1 NLRX1 CPNE2 CPNE2 IRAK2 IRAK2 PSMC3 PSMC3 STAT3 STAT3 TNIP2 TNIP2 PSME3 PSME3 APP APP ENSVVUP00000033526 ENSVVUP00000033526 LOC112910913 LOC112910913 ENSVVUP00000033877 ENSVVUP00000033877 IL13 IL13 CHUK CHUK AGER AGER PSMB8 PSMB8 PSMB9 PSMB9 ENSVVUP00000035544 ENSVVUP00000035544 PSMD1 PSMD1 IL18BP IL18BP UBC UBC TRAF2 TRAF2 ENSVVUP00000036620 ENSVVUP00000036620 ENSVVUP00000037430 ENSVVUP00000037430 PELI3 PELI3 RELA RELA PSMB6 PSMB6 PTPN21 PTPN21 NKIRAS1 NKIRAS1 S100A12 S100A12 ENSVVUP00000040094 ENSVVUP00000040094 IL1A IL1A IL1B IL1B IL37 IL37 IL36G IL36G LOC112916862 LOC112916862 IL36RN IL36RN IL1F10 IL1F10 IL1RN IL1RN PSME1 PSME1 PSME2 PSME2 KHNYN KHNYN CTSG CTSG ENSVVUP00000041077 ENSVVUP00000041077 ENSVVUP00000041103 ENSVVUP00000041103 GZMB GZMB IKBKG IKBKG PSMA3 PSMA3 PELI2 PELI2 IRAK1 IRAK1 PSMC6 PSMC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (782 aa)
LRRC34Leucine-rich repeat-containing protein 34. (402 aa)
LRRC31Leucine-rich repeat-containing protein 31 isoform X1. (457 aa)
PSMB2Proteasome subunit beta. (189 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
LRRC45Leucine-rich repeat-containing protein 45. (670 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
SQSTM1Sequestosome-1. (444 aa)
TIFATRAF-interacting protein with FHA domain-containing protein A. (163 aa)
ALPK1Alpha-protein kinase 1 isoform X1. (1237 aa)
TOLLIPToll-interacting protein isoform X1. (274 aa)
PSMA8Proteasome endopeptidase complex. (405 aa)
PSMB3Proteasome subunit beta. (196 aa)
PTPN5Tyrosine-protein phosphatase non-receptor type 5 isoform X2. (583 aa)
ENSVVUP00000003182annotation not available (261 aa)
PSMA5Proteasome subunit alpha type. (264 aa)
LRRC74ALeucine-rich repeat-containing protein 74A. (489 aa)
PTPN23Tyrosine-protein phosphatase non-receptor type 23. (1646 aa)
NFKB2LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit. (863 aa)
ENSVVUP00000005276annotation not available (161 aa)
LOC112923316Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (263 aa)
ENSVVUP00000005490annotation not available (72 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (545 aa)
LOC112919437Proteasome subunit alpha type-1-like. (265 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
LOC112925668High mobility group protein B1-like. (207 aa)
LRRC14Leucine-rich repeat-containing protein 14 isoform X1. (492 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (616 aa)
TONSLTonsoku-like protein. (1165 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
ENSVVUP00000007999annotation not available (96 aa)
PSMC526S proteasome regulatory subunit 8 isoform X1; Belongs to the AAA ATPase family. (406 aa)
LOC112921655Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LRRC71Leucine-rich repeat-containing protein 71. (536 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X1. (456 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
NLRP13NACHT, LRR and PYD domains-containing protein 13-like. (1029 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9. (995 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
PSMB1Proteasome subunit beta. (294 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LOC112928967Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
ENSVVUP00000009448annotation not available (262 aa)
ENSVVUP00000010304annotation not available (270 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1. (717 aa)
PSME4Proteasome activator complex subunit 4. (1823 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
UBA52ubiquitin-60S ribosomal protein L40. (231 aa)
PSMF1Proteasome inhibitor PI31 subunit isoform X1. (418 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type 14. (1263 aa)
VWC2LVon Willebrand factor C domain-containing protein 2-like. (222 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
ENSVVUP00000012574annotation not available (262 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
HMGB1High mobility group protein B1. (215 aa)
PSMB7Proteasome subunit beta. (239 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
ENSVVUP00000014079annotation not available (196 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2 isoform X2. (619 aa)
ENSVVUP00000014607annotation not available (200 aa)
ENSVVUP00000014764annotation not available (139 aa)
IRAK3Interleukin-1 receptor-associated kinase 3. (597 aa)
ENSVVUP00000016091annotation not available (109 aa)
ENSVVUP00000016245annotation not available (152 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (461 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
IL1RAPL1Interleukin-1 receptor accessory protein-like 1. (407 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
PSMB10Proteasome subunit beta. (273 aa)
IL18RAPInterleukin-18 receptor accessory protein. (620 aa)
IL18R1Interleukin-18 receptor 1. (546 aa)
IL1RL1Interleukin-1 receptor-like 1. (557 aa)
IL1RL2Interleukin-1 receptor-like 2. (554 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (410 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (726 aa)
IL1R2Interleukin-1 receptor type 2. (415 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ENSVVUP00000017628annotation not available (263 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (452 aa)
LOC112932868Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
IL1RAPInterleukin-1 receptor accessory protein. (685 aa)
MAP3K20-2Mitogen-activated protein kinase kinase kinase 20 isoform X2. (487 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X1. (509 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (502 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (389 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (820 aa)
PSMA7Proteasome endopeptidase complex. (243 aa)
IL18Interleukin-18. (236 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (875 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (477 aa)
SIGIRRSingle Ig IL-1-related receptor isoform X1. (435 aa)
ENSVVUP00000023416Ubiquitin-conjugating enzyme E2 N-like. (105 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (324 aa)
ENSVVUP00000023942Ubiquitin-conjugating enzyme E2 N-like. (93 aa)
N4BP1NEDD4-binding protein 1. (1009 aa)
ENSVVUP00000024657annotation not available (103 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (453 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (397 aa)
PTPN9Tyrosine-protein phosphatase non-receptor type 9. (579 aa)
ENSVVUP00000026875annotation not available (107 aa)
PSMB5Proteasome subunit beta. (277 aa)
PSMB11Proteasome subunit beta. (327 aa)
ENSVVUP00000027142annotation not available (182 aa)
PSMA6Proteasome subunit alpha type. (228 aa)
NFKBIANF-kappa-B inhibitor alpha. (327 aa)
ENSVVUP00000027292Ubiquitin-conjugating enzyme E2 N-like. (146 aa)
IL33Interleukin-33. (263 aa)
ENSVVUP00000027737annotation not available (222 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11 isoform X1. (410 aa)
PTPN20Tyrosine-protein phosphatase non-receptor type 20 isoform X7. (418 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2. (209 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
ENSVVUP00000029422Ubiquitin-conjugating enzyme E2 N-like. (89 aa)
LRRC74BLeucine-rich repeat-containing protein 74B. (396 aa)
ENSVVUP00000029975annotation not available (85 aa)
ENSVVUP00000030237annotation not available (144 aa)
UBE2V1Ubiquitin-conjugating enzyme E2 variant 1 isoform X3. (105 aa)
LOC112917600Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
MFSD1Major facilitator superfamily domain-containing protein 1 isoform X1. (465 aa)
GSDMDgasdermin-D. (473 aa)
USP18Ubl carboxyl-terminal hydrolase 18 isoform X1; Belongs to the peptidase C19 family. (339 aa)
NLRX1NLR family member X1 isoform X1. (975 aa)
CPNE2Protein NLRC5. (1868 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (598 aa)
PSMC326S proteasome regulatory subunit 6A isoform X2; Belongs to the AAA ATPase family. (581 aa)
STAT3Signal transducer and activator of transcription. (791 aa)
TNIP2TNFAIP3-interacting protein 2 isoform X1. (435 aa)
PSME3Proteasome activator complex subunit 3. (247 aa)
APPAmyloid-beta A4 protein isoform X1. (770 aa)
ENSVVUP00000033526annotation not available (137 aa)
LOC112910913Ubiquitin-like. (77 aa)
ENSVVUP00000033877annotation not available (238 aa)
IL13Interleukin-13. (131 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
AGERAdvanced glycosylation end product-specific receptor. (405 aa)
PSMB8Proteasome subunit beta. (306 aa)
PSMB9Proteasome subunit beta. (209 aa)
ENSVVUP00000035544annotation not available (382 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1037 aa)
IL18BPInterleukin-18-binding protein isoform X1. (288 aa)
UBCpolyubiquitin-C. (190 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (533 aa)
ENSVVUP00000036620annotation not available (157 aa)
ENSVVUP00000037430annotation not available (99 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
RELATranscription factor p65 isoform X2. (542 aa)
PSMB6Proteasome subunit beta. (239 aa)
PTPN21Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1154 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1. (206 aa)
S100A12Protein S100; Belongs to the S-100 family. (110 aa)
ENSVVUP00000040094annotation not available (128 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
IL37Interleukin-1. (126 aa)
IL36GInterleukin-1. (167 aa)
LOC112916862Interleukin-1. (202 aa)
IL36RNInterleukin-1. (147 aa)
IL1F10Interleukin-1. (152 aa)
IL1RNInterleukin-1. (176 aa)
PSME1Proteasome activator complex subunit 1. (279 aa)
PSME2Proteasome activator complex subunit 2 isoform X1. (239 aa)
KHNYNProtein KHNYN. (669 aa)
CTSGCathepsin G-like; Belongs to the peptidase S1 family. (304 aa)
ENSVVUP00000041077annotation not available (147 aa)
ENSVVUP00000041103annotation not available (105 aa)
GZMBGranzyme B-like; Belongs to the peptidase S1 family. (292 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (551 aa)
PSMC626S proteasome regulatory subunit 10B isoform X1; Belongs to the AAA ATPase family. (403 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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