STRINGSTRING
ENSVVUP00000016245 ENSVVUP00000016245 PSMB2 PSMB2 BTRC BTRC PSMD3 PSMD3 PSMA8 PSMA8 PSMB3 PSMB3 ENSVVUP00000003182 ENSVVUP00000003182 PSMA5 PSMA5 ENSVVUP00000005276 ENSVVUP00000005276 SUFU SUFU LOC112923316 LOC112923316 ENSVVUP00000005490 ENSVVUP00000005490 ITCH ITCH NUMB NUMB LOC112919437 LOC112919437 COQ8B COQ8B PSMC4 PSMC4 PSMC5 PSMC5 PSMD12 PSMD12 PSMA2 PSMA2 RBX1 RBX1 PSMB1 PSMB1 ENSVVUP00000009448 ENSVVUP00000009448 ENSVVUP00000010304 ENSVVUP00000010304 PSME4 PSME4 PSMA4 PSMA4 UBA52 UBA52 PSMF1 PSMF1 ENSVVUP00000012574 ENSVVUP00000012574 PSMB7 PSMB7 RPS27A RPS27A PSMD10 PSMD10 ENSVVUP00000014607 ENSVVUP00000014607 ENSVVUP00000014764 ENSVVUP00000014764 PSMD5 PSMD5 ENSVVUP00000016277 ENSVVUP00000016277 PSMD2 PSMD2 PSMB10 PSMB10 PSMD4 PSMD4 PSMB4 PSMB4 ENSVVUP00000017628 ENSVVUP00000017628 PSMD8 PSMD8 PSMC2 PSMC2 PSMD6 PSMD6 PSMA7 PSMA7 CUL1 CUL1 PSMD13 PSMD13 PSMD7 PSMD7 GLI1 GLI1 PSMC1 PSMC1 PSMD14 PSMD14 ENSVVUP00000026875 ENSVVUP00000026875 PSMB5 PSMB5 PSMB11 PSMB11 PSMA6 PSMA6 ENSVVUP00000027737 ENSVVUP00000027737 PSMD11 PSMD11 SKP1 SKP1 ENSVVUP00000029975 ENSVVUP00000029975 ENSVVUP00000030237 ENSVVUP00000030237 PSMC3 PSMC3 PSME3 PSME3 ENSVVUP00000033526 ENSVVUP00000033526 ENSVVUP00000033527 ENSVVUP00000033527 LOC112910913 LOC112910913 ENSVVUP00000033877 ENSVVUP00000033877 PSMB8 PSMB8 PSMB9 PSMB9 ENSVVUP00000035544 ENSVVUP00000035544 PSMD1 PSMD1 UBC UBC ENSVVUP00000036620 ENSVVUP00000036620 PSMB6 PSMB6 ENSVVUP00000040094 ENSVVUP00000040094 PSME1 PSME1 PSME2 PSME2 ENSVVUP00000041103 ENSVVUP00000041103 PSMA3 PSMA3 PSMC6 PSMC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSVVUP00000016245annotation not available (152 aa)
PSMB2Proteasome subunit beta. (189 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
PSMA8Proteasome endopeptidase complex. (405 aa)
PSMB3Proteasome subunit beta. (196 aa)
ENSVVUP00000003182annotation not available (261 aa)
PSMA5Proteasome subunit alpha type. (264 aa)
ENSVVUP00000005276annotation not available (161 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (490 aa)
LOC112923316Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (263 aa)
ENSVVUP00000005490annotation not available (72 aa)
ITCHE3 ubiquitin-protein ligase. (1100 aa)
NUMBProtein numb homolog isoform X3. (666 aa)
LOC112919437Proteasome subunit alpha type-1-like. (265 aa)
COQ8BNumb-like protein isoform X3. (1023 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMC526S proteasome regulatory subunit 8 isoform X1; Belongs to the AAA ATPase family. (406 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X1. (456 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
PSMB1Proteasome subunit beta. (294 aa)
ENSVVUP00000009448annotation not available (262 aa)
ENSVVUP00000010304annotation not available (270 aa)
PSME4Proteasome activator complex subunit 4. (1823 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
UBA52ubiquitin-60S ribosomal protein L40. (231 aa)
PSMF1Proteasome inhibitor PI31 subunit isoform X1. (418 aa)
ENSVVUP00000012574annotation not available (262 aa)
PSMB7Proteasome subunit beta. (239 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
ENSVVUP00000014607annotation not available (200 aa)
ENSVVUP00000014764annotation not available (139 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (461 aa)
ENSVVUP00000016277annotation not available (152 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (410 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ENSVVUP00000017628annotation not available (263 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (452 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (389 aa)
PSMA7Proteasome endopeptidase complex. (243 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (324 aa)
GLI1Zinc finger protein GLI1. (1105 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (453 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
ENSVVUP00000026875annotation not available (107 aa)
PSMB5Proteasome subunit beta. (277 aa)
PSMB11Proteasome subunit beta. (327 aa)
PSMA6Proteasome subunit alpha type. (228 aa)
ENSVVUP00000027737annotation not available (222 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11 isoform X1. (410 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
ENSVVUP00000029975annotation not available (85 aa)
ENSVVUP00000030237annotation not available (144 aa)
PSMC326S proteasome regulatory subunit 6A isoform X2; Belongs to the AAA ATPase family. (581 aa)
PSME3Proteasome activator complex subunit 3. (247 aa)
ENSVVUP00000033526annotation not available (137 aa)
ENSVVUP00000033527annotation not available (166 aa)
LOC112910913Ubiquitin-like. (77 aa)
ENSVVUP00000033877annotation not available (238 aa)
PSMB8Proteasome subunit beta. (306 aa)
PSMB9Proteasome subunit beta. (209 aa)
ENSVVUP00000035544annotation not available (382 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1037 aa)
UBCpolyubiquitin-C. (190 aa)
ENSVVUP00000036620annotation not available (157 aa)
PSMB6Proteasome subunit beta. (239 aa)
ENSVVUP00000040094annotation not available (128 aa)
PSME1Proteasome activator complex subunit 1. (279 aa)
PSME2Proteasome activator complex subunit 2 isoform X1. (239 aa)
ENSVVUP00000041103annotation not available (105 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC626S proteasome regulatory subunit 10B isoform X1; Belongs to the AAA ATPase family. (403 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.