(26 nodes) Translesion synthesis by POLK network (Vulpes vulpes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	LOC112926201	LOW QUALITY PROTEIN: replication factor C subunit 5-like. (304 aa)
	REV3L	DNA polymerase zeta catalytic subunit isoform X2. (3138 aa)
	ENSVVUP00000005165	annotation not available (81 aa)
	ENSVVUP00000014764	annotation not available (139 aa)
	RPA2	Replication protein A 32 kDa subunit isoform X2. (269 aa)
	RFC5	Replication factor C subunit 5. (331 aa)
	RFC4	Replication factor C subunit 4. (424 aa)
	RFC1	Replication factor C subunit 1. (1166 aa)
	ENSVVUP00000020720	annotation not available (254 aa)
	RPA3	Replication protein A 14 kDa subunit. (245 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	LOC112910913	Ubiquitin-like. (77 aa)
	RFC2	Replication factor C subunit 2 isoform X1. (496 aa)
	POLK	DNA polymerase kappa isoform X1. (861 aa)
	UBC	polyubiquitin-C. (190 aa)
	RFC3	Replication factor C subunit 3 isoform X1. (355 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1. (531 aa)
	RCBTB2	RCC1 and BTB domain-containing protein 2 isoform X2. (443 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
	ENSVVUP00000040094	annotation not available (128 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa)
	ATAD5	ATPase family AAA domain-containing protein 5. (1882 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein. (471 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (156 aa)
	UBA52	ubiquitin-60S ribosomal protein L40. (231 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ENSVVUP00000014764	ENSVVUP00000016522	ENSVVUP00000014764	ATPase family AAA domain-containing protein 5.	annotation not available	0.443
ATAD5	ENSVVUP00000020720	ENSVVUP00000016522	ENSVVUP00000020720	ATPase family AAA domain-containing protein 5.	annotation not available	0.539
ATAD5	LOC112926201	ENSVVUP00000016522	ENSVVUP00000008901	ATPase family AAA domain-containing protein 5.	LOW QUALITY PROTEIN: replication factor C subunit 5-like.	0.920
ATAD5	MAD2L2	ENSVVUP00000016522	ENSVVUP00000039963	ATPase family AAA domain-containing protein 5.	Mitotic spindle assembly checkpoint protein MAD2B.	0.602
ATAD5	MEIOB	ENSVVUP00000016522	ENSVVUP00000013510	ATPase family AAA domain-containing protein 5.	Meiosis-specific with OB domain-containing protein.	0.711
ATAD5	PCNA	ENSVVUP00000016522	ENSVVUP00000033727	ATPase family AAA domain-containing protein 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.959
ATAD5	POLK	ENSVVUP00000016522	ENSVVUP00000034976	ATPase family AAA domain-containing protein 5.	DNA polymerase kappa isoform X1.	0.610
ATAD5	REV1	ENSVVUP00000016522	ENSVVUP00000040192	ATPase family AAA domain-containing protein 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.622
ATAD5	REV3L	ENSVVUP00000016522	ENSVVUP00000008879	ATPase family AAA domain-containing protein 5.	DNA polymerase zeta catalytic subunit isoform X2.	0.712
ATAD5	RFC1	ENSVVUP00000016522	ENSVVUP00000019786	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 1.	0.660
ATAD5	RFC2	ENSVVUP00000016522	ENSVVUP00000034408	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 2 isoform X1.	0.972
ATAD5	RFC3	ENSVVUP00000016522	ENSVVUP00000037095	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 3 isoform X1.	0.971
ATAD5	RFC4	ENSVVUP00000016522	ENSVVUP00000017999	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 4.	0.983
ATAD5	RFC5	ENSVVUP00000016522	ENSVVUP00000017918	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 5.	0.920
ATAD5	RPA1	ENSVVUP00000016522	ENSVVUP00000029706	ATPase family AAA domain-containing protein 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.711
ATAD5	RPA2	ENSVVUP00000016522	ENSVVUP00000016622	ATPase family AAA domain-containing protein 5.	Replication protein A 32 kDa subunit isoform X2.	0.539
ATAD5	RPA3	ENSVVUP00000016522	ENSVVUP00000021744	ATPase family AAA domain-containing protein 5.	Replication protein A 14 kDa subunit.	0.569
ATAD5	RPS27A	ENSVVUP00000016522	ENSVVUP00000013492	ATPase family AAA domain-containing protein 5.	ubiquitin-40S ribosomal protein S27a.	0.443
ENSVVUP00000014764	ATAD5	ENSVVUP00000014764	ENSVVUP00000016522	annotation not available	ATPase family AAA domain-containing protein 5.	0.443
ENSVVUP00000014764	ENSVVUP00000020720	ENSVVUP00000014764	ENSVVUP00000020720	annotation not available	annotation not available	0.509