Your Input: | |
| | POLE4 | DNA polymerase epsilon subunit 4. (118 aa) |
| | ENSVVUP00000005165 | annotation not available (81 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1 isoform X1. (405 aa) |
| | ENSVVUP00000005363 | annotation not available (77 aa) |
| | ENSVVUP00000005372 | annotation not available (50 aa) |
| | ENSVVUP00000005377 | annotation not available (72 aa) |
| | LOC112908355 | LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like. (270 aa) |
| | TP53BP1 | TP53-binding protein 1 isoform X1. (1976 aa) |
| | MDC1 | Mediator of DNA damage checkpoint protein 1 isoform X2. (1910 aa) |
| | RPS27A | ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (557 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (469 aa) |
| | HERC2 | E3 ubiquitin-protein ligase HERC2 isoform X1. (4837 aa) |
| | ENSVVUP00000011628 | annotation not available (1275 aa) |
| | ENSVVUP00000011815 | annotation not available (1098 aa) |
| | ENSVVUP00000011830 | annotation not available (762 aa) |
| | ENSVVUP00000012001 | annotation not available (1275 aa) |
| | SIRT6 | NAD-dependent protein deacetylase sirtuin-6 isoform X1. (330 aa) |
| | PIAS4 | E3 SUMO-protein ligase PIAS4. (597 aa) |
| | UBA52 | ubiquitin-60S ribosomal protein L40. (231 aa) |
| | ENSVVUP00000010733 | annotation not available (80 aa) |
| | RMI1 | recQ-mediated genome instability protein 1. (649 aa) |
| | ENSVVUP00000010438 | Late histone H2B.L4-like. (67 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3060 aa) |
| | ABRAXAS1 | BRCA1-A complex subunit Abraxas 1 isoform X1. (409 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (245 aa) |
| | BABAM1 | BRISC and BRCA1-A complex member 1. (336 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4. (1743 aa) |
| | RAD9B | Cell cycle checkpoint control protein RAD9B. (421 aa) |
| | ENSVVUP00000023196 | annotation not available (1275 aa) |
| | ENSVVUP00000023351 | annotation not available (1275 aa) |
| | ENSVVUP00000023416 | Ubiquitin-conjugating enzyme E2 N-like. (105 aa) |
| | ENSVVUP00000023942 | Ubiquitin-conjugating enzyme E2 N-like. (93 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. (152 aa) |
| | ENSVVUP00000024144 | annotation not available (670 aa) |
| | RAD51AP1 | RAD51-associated protein 1. (343 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein. (471 aa) |
| | ENSVVUP00000014236 | annotation not available (690 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (397 aa) |
| | POLD4 | DNA polymerase delta subunit 4. (107 aa) |
| | ENSVVUP00000020720 | annotation not available (254 aa) |
| | ENSVVUP00000020633 | annotation not available (868 aa) |
| | CDK3 | Cyclin-dependent kinase 3 isoform X3; Belongs to the protein kinase superfamily. (305 aa) |
| | RAD51D | DNA repair protein RAD51 homolog 4 isoform X1. (328 aa) |
| | RFC1 | Replication factor C subunit 1. (1166 aa) |
| | ENSVVUP00000019626 | annotation not available (986 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (265 aa) |
| | ENSVVUP00000019449 | annotation not available (882 aa) |
| | ENSVVUP00000019289 | annotation not available (1218 aa) |
| | ENSVVUP00000019204 | annotation not available (694 aa) |
| | ENSVVUP00000019172 | annotation not available (882 aa) |
| | ENSVVUP00000018970 | annotation not available (760 aa) |
| | ENSVVUP00000018906 | annotation not available (707 aa) |
| | PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2. (416 aa) |
| | ENSVVUP00000018228 | annotation not available (836 aa) |
| | CCNA2 | cyclin-A2; Belongs to the cyclin family. (431 aa) |
| | LOC112932868 | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (140 aa) |
| | RFC4 | Replication factor C subunit 4. (424 aa) |
| | RFC5 | Replication factor C subunit 5. (331 aa) |
| | RAD51C | DNA repair protein RAD51 homolog 3 isoform X1. (382 aa) |
| | RPA2 | Replication protein A 32 kDa subunit isoform X2. (269 aa) |
| | ENSVVUP00000016322 | annotation not available (1275 aa) |
| | ENSVVUP00000016230 | annotation not available (1275 aa) |
| | ANKRD12 | Ankyrin repeat domain-containing protein 12 isoform X1. (2061 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) |
| | ENSVVUP00000015370 | annotation not available (81 aa) |
| | ENSVVUP00000015336 | annotation not available (1275 aa) |
| | ENSVVUP00000015251 | annotation not available (757 aa) |
| | ENSVVUP00000014839 | annotation not available (1196 aa) |
| | ENSVVUP00000014764 | annotation not available (139 aa) |
| | ENSVVUP00000024478 | annotation not available (157 aa) |
| | ENSVVUP00000024657 | annotation not available (103 aa) |
| | RHNO1 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (255 aa) |
| | BRIP1 | Fanconi anemia group J protein. (1272 aa) |
| | SPIDR | DNA repair-scaffolding protein isoform X2. (918 aa) |
| | ERCC4 | DNA repair endonuclease XPF isoform X1. (916 aa) |
| | LOC112917557 | Histone H4. (103 aa) |
| | EME1 | Crossover junction endonuclease EME1. (579 aa) |
| | ENSVVUP00000007170 | annotation not available (1283 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1 isoform X2. (1512 aa) |
| | ENSVVUP00000007531 | annotation not available (740 aa) |
| | ENSVVUP00000007888 | annotation not available (881 aa) |
| | ENSVVUP00000007903 | annotation not available (1275 aa) |
| | PALB2 | Partner and localizer of BRCA2 isoform X2. (1301 aa) |
| | ENSVVUP00000007989 | annotation not available (1275 aa) |
| | LOC112921655 | Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | LOC112923719 | Late histone H2B.L4-like; Belongs to the histone H2B family. (122 aa) |
| | BLM | Bloom syndrome protein. (1420 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2279 aa) |
| | LOC112926201 | LOW QUALITY PROTEIN: replication factor C subunit 5-like. (304 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17 isoform X1. (680 aa) |
| | LOC112928967 | Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | XRCC2 | DNA repair protein XRCC2. (279 aa) |
| | LOC112908299 | Histone H2B subacrosomal variant-like; Belongs to the histone H2B family. (124 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC112907712 | Histone H4. (103 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | SIRT7 | NAD-dependent protein deacetylase sirtuin-7. (475 aa) |
| | CLSPN | Claspin isoform X2. (667 aa) |
| | LOC112910316 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC112910323 | Histone H4. (103 aa) |
| | ENSVVUP00000001123 | annotation not available (140 aa) |
| | XRCC3 | DNA repair protein XRCC3. (349 aa) |
| | ENSVVUP00000001448 | annotation not available (740 aa) |
| | POLK | DNA polymerase kappa isoform X1. (861 aa) |
| | LOC112910316-2 | Histone H2B type 1. (126 aa) |
| | ENSVVUP00000035131 | annotation not available (129 aa) |
| | ENSVVUP00000026914 | annotation not available (1275 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1455 aa) |
| | ENSVVUP00000027292 | Ubiquitin-conjugating enzyme E2 N-like. (146 aa) |
| | ENSVVUP00000027538 | annotation not available (149 aa) |
| | POLD1 | DNA polymerase. (1107 aa) |
| | ENSVVUP00000027565 | annotation not available (103 aa) |
| | ENSVVUP00000027572 | annotation not available (103 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1054 aa) |
| | LOC112910324 | Histone H4. (103 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSVVUP00000035151 | annotation not available (103 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSVVUP00000035209 | annotation not available (103 aa) |
| | ENSVVUP00000035950 | annotation not available (848 aa) |
| | UBC | polyubiquitin-C. (190 aa) |
| | ENSVVUP00000000332 | annotation not available (126 aa) |
| | ENSVVUP00000036034 | annotation not available (645 aa) |
| | SLX1A | SLX1 homolog A, structure-specific endonuclease subunit. (161 aa) |
| | LOC112910323-2 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC112920488 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | ENSVVUP00000034954 | annotation not available (680 aa) |
| | ENSVVUP00000034494 | annotation not available (657 aa) |
| | RFC2 | Replication factor C subunit 2 isoform X1. (496 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1312 aa) |
| | LOC112910913 | Ubiquitin-like. (77 aa) |
| | POLD3 | DNA polymerase delta subunit 3 isoform X1. (466 aa) |
| | RNF169 | E3 ubiquitin-protein ligase RNF169. (556 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | ATR | Serine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2637 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1891 aa) |
| | RNF4 | E3 ubiquitin-protein ligase RNF4. (191 aa) |
| | NSD2 | LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2. (1344 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | ENSVVUP00000031626 | annotation not available (1275 aa) |
| | ENSVVUP00000030431 | annotation not available (740 aa) |
| | CDK2 | Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (281 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor protein 1. (1059 aa) |
| | ENSVVUP00000030130 | annotation not available (269 aa) |
| | ENSVVUP00000030088 | annotation not available (155 aa) |
| | ENSVVUP00000030078 | annotation not available (246 aa) |
| | ENSVVUP00000029970 | annotation not available (1275 aa) |
| | ENSVVUP00000029866 | annotation not available (67 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | TIMELESS | Protein timeless homolog isoform X1. (1248 aa) |
| | ENSVVUP00000028955 | annotation not available (657 aa) |
| | ENSVVUP00000028947 | annotation not available (1275 aa) |
| | LOC112926351 | Ubiquitin-conjugating enzyme E2 variant 1-like. (80 aa) |
| | BRCC3 | Lys-63-specific deubiquitinase BRCC36. (263 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa) |
| | GEN1 | Flap endonuclease GEN homolog 1. (906 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | ENSVVUP00000036716 | annotation not available (882 aa) |
| | ENSVVUP00000036812 | annotation not available (713 aa) |
| | EXO1 | Exonuclease 1. (844 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (539 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3446 aa) |
| | ENSVVUP00000037043 | annotation not available (113 aa) |
| | RFC3 | Replication factor C subunit 3 isoform X1. (355 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (348 aa) |
| | CCNA1 | cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa) |
| | MUS81 | Crossover junction endonuclease MUS81 isoform X2. (697 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (555 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | ENSVVUP00000038889 | annotation not available (677 aa) |
| | LOC112934396 | Histone H2B; Belongs to the histone H2B family. (118 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (531 aa) |
| | RCBTB2 | RCC1 and BTB domain-containing protein 2 isoform X2. (443 aa) |
| | ENSVVUP00000039733 | annotation not available (740 aa) |
| | ENSVVUP00000040094 | annotation not available (128 aa) |
| | ENSVVUP00000040219 | annotation not available (816 aa) |
| | POLH | DNA polymerase eta isoform X1. (709 aa) |
| | TDRD3 | Tudor domain-containing protein 3 isoform X3. (799 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (297 aa) |
| | ATRIP | ATR-interacting protein isoform X2. (792 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (531 aa) |
| | RAD52 | DNA repair protein RAD52 homolog. (758 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (987 aa) |
| | ENSVVUP00000042749 | annotation not available (72 aa) |
| | LOC112911986 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | LOC112911984 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (719 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (777 aa) |
| | ENSVVUP00000001739 | annotation not available (1303 aa) |
| | ENSVVUP00000002040 | annotation not available (1028 aa) |
| | ENSVVUP00000002067 | annotation not available (796 aa) |
| | BABAM2 | BRISC and BRCA1-A complex member 2 isoform X2. (497 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (792 aa) |
| | ENSVVUP00000002949 | annotation not available (75 aa) |
| | ENSVVUP00000003279 | annotation not available (1275 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (306 aa) |
| | RAD51B | DNA repair protein RAD51 homolog 2 isoform X3. (271 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2 isoform X1. (626 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (900 aa) |
