STRINGSTRING
RFFL RFFL PPP2CB PPP2CB TXNDC11 TXNDC11 USP7 USP7 RNF34 RNF34 ATM ATM PPP2R1B PPP2R1B CDK3 CDK3 MDM4 MDM4 CCNA2 CCNA2 PPP2R1A PPP2R1A ENSVVUP00000014764 ENSVVUP00000014764 ENSVVUP00000013888 ENSVVUP00000013888 MDM2 MDM2 MAPKAP1 MAPKAP1 RPS27A RPS27A MLST8 MLST8 ENSVVUP00000012585 ENSVVUP00000012585 ENSVVUP00000012275 ENSVVUP00000012275 PDPK1 PDPK1 CDK1 CDK1 UBA52 UBA52 AKT2 AKT2 ENSVVUP00000005393 ENSVVUP00000005393 CCNG1 CCNG1 AKT1 AKT1 ENSVVUP00000003770 ENSVVUP00000003770 RICTOR RICTOR PHF20 PHF20 SGK1 SGK1 ENSVVUP00000040094 ENSVVUP00000040094 PRR5 PRR5 PPP2R5C PPP2R5C MTOR MTOR TP53 TP53 ENSVVUP00000037728 ENSVVUP00000037728 CCNA1 CCNA1 AKT3 AKT3 UBC UBC DAXX DAXX LOC112910878 LOC112910878 LOC112910913 LOC112910913 USP2 USP2 CDK2 CDK2 PPP2CA PPP2CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RFFLE3 ubiquitin-protein ligase rififylin isoform X2. (386 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
TXNDC11Thioredoxin domain-containing protein 11. (933 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family. (1164 aa)
RNF34E3 ubiquitin-protein ligase RNF34 isoform X1. (412 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3060 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (656 aa)
CDK3Cyclin-dependent kinase 3 isoform X3; Belongs to the protein kinase superfamily. (305 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (431 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
ENSVVUP00000014764annotation not available (139 aa)
ENSVVUP00000013888annotation not available (128 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (177 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (587 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
ENSVVUP00000012585annotation not available (79 aa)
ENSVVUP00000012275annotation not available (104 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
CDK1LOW QUALITY PROTEIN: cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (274 aa)
UBA52ubiquitin-60S ribosomal protein L40. (231 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
ENSVVUP00000005393annotation not available (155 aa)
CCNG1cyclin-G1; Belongs to the cyclin family. (295 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSVVUP00000003770annotation not available (153 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1684 aa)
PHF20PHD finger protein 20. (1013 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
ENSVVUP00000040094annotation not available (128 aa)
PRR5Proline-rich protein 5. (401 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSVVUP00000037728annotation not available (62 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
UBCpolyubiquitin-C. (190 aa)
DAXXDeath domain-associated protein 6 isoform X2. (733 aa)
LOC112910878cyclin-G1. (151 aa)
LOC112910913Ubiquitin-like. (77 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (667 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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