STRINGSTRING
FAM102B FAM102B PPP2CA PPP2CA IRAK1 IRAK1 STRN3 STRN3 PPP2R5E PPP2R5E SRC SRC PDGFA PDGFA ENSVVUP00000040442 ENSVVUP00000040442 PPP2R5C PPP2R5C INSR INSR ESR2 ESR2 FNDC3A FNDC3A SPEM2 SPEM2 SPEM1 SPEM1 PPP2R5D PPP2R5D PPP2R5B PPP2R5B PIK3CB PIK3CB KL KL WDR64 WDR64 PIK3CD PIK3CD MAPK3 MAPK3 IRS1 IRS1 RHOG RHOG NRG3 NRG3 FGF10 FGF10 KIT KIT PDGFRA PDGFRA FGF5 FGF5 INSC INSC CD19 CD19 RAC2 RAC2 FGFR3 FGFR3 FNBP4 FNBP4 PIK3AP1 PIK3AP1 GAB2 GAB2 ENSVVUP00000031059 ENSVVUP00000031059 FLT3LG FLT3LG CD86 CD86 CD80 CD80 ERBB3 ERBB3 FGF8 FGF8 FGFR4 FGFR4 TRAT1 TRAT1 ERBB2 ERBB2 FNDC3B FNDC3B PIP4K2B PIP4K2B STRN4 STRN4 FGF18 FGF18 INS INS AKT1 AKT1 LOC112907617 LOC112907617 PIP5K1C PIP5K1C ENSVVUP00000004522 ENSVVUP00000004522 ENSVVUP00000004929 ENSVVUP00000004929 LOC112926139 LOC112926139 ENSVVUP00000005393 ENSVVUP00000005393 PIP5K1B PIP5K1B FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 PIK3CA PIK3CA MYD88 MYD88 ESR1 ESR1 PIK3R1 PIK3R1 FYN FYN TRAF6 TRAF6 FGF17 FGF17 LOC112914774 LOC112914774 PDGFRB PDGFRB FGF20 FGF20 FGF9 FGF9 PPP2R5A PPP2R5A GAB1 GAB1 BANK1 BANK1 ERBB4 ERBB4 FLT3 FLT3 PIK3R2 PIK3R2 LOC112918532 LOC112918532 EGFR EGFR NRG2 NRG2 HBEGF HBEGF FRS2 FRS2 PTPN11 PTPN11 PIP4K2A PIP4K2A IER3 IER3 PPP2R1A PPP2R1A GRB2 GRB2 FGFR2 FGFR2 KITLG KITLG PPP4R1 PPP4R1 ENSVVUP00000016557 ENSVVUP00000016557 IL1RL1 IL1RL1 PIP5K1A PIP5K1A ENSVVUP00000017517 ENSVVUP00000017517 PIP5KL1 PIP5KL1 FAM102A FAM102A IL1RAP IL1RAP FGF2 FGF2 FGF16 FGF16 PDGFB PDGFB KLB KLB AREG AREG EREG EREG EPGN EPGN SRMS SRMS LCK LCK PPP2R1B PPP2R1B FGF7 FGF7 IRAK4 IRAK4 ENSVVUP00000023156 ENSVVUP00000023156 ICOS ICOS CD28 CD28 PIP4K2C PIP4K2C LOC112932177 LOC112932177 RELCH RELCH EGF EGF ENSVVUP00000024290 ENSVVUP00000024290 FGF6 FGF6 FGF23 FGF23 CD276 CD276 PPP4R4 PPP4R4 STRN STRN HGF HGF PPP2CB PPP2CB NRG1 NRG1 FGFR1 FGFR1 VAV1 VAV1 IL33 IL33 MAPK1 MAPK1 ENSVVUP00000028266 ENSVVUP00000028266 IRS2 IRS2 FGF1 FGF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAM102BProtein FAM102B. (360 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (551 aa)
STRN3LOW QUALITY PROTEIN: striatin-3. (779 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (498 aa)
SRCTyrosine-protein kinase. (536 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (343 aa)
ENSVVUP00000040442annotation not available (64 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
ESR2Estrogen receptor beta. (530 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
SPEM2Uncharacterized protein SPEM2. (457 aa)
SPEM1Spermatid maturation protein 1. (312 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (604 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
KLKlotho. (266 aa)
WDR64WD repeat-containing protein 64. (1090 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1062 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform. (345 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
KITMast/stem cell growth factor receptor Kit. (274 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1111 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
INSCProtein inscuteable homolog. (578 aa)
CD19B-lymphocyte antigen CD19. (626 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (173 aa)
FGFR3Fibroblast growth factor receptor. (876 aa)
FNBP4LOW QUALITY PROTEIN: formin-binding protein 4. (1022 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (789 aa)
GAB2GRB2-associated-binding protein 2. (666 aa)
ENSVVUP00000031059annotation not available (170 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (294 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (343 aa)
CD80T-lymphocyte activation antigen CD80. (235 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1342 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
FGFR4Fibroblast growth factor receptor. (844 aa)
TRAT1T-cell receptor-associated transmembrane adapter 1. (181 aa)
ERBB2Receptor protein-tyrosine kinase. (1266 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1220 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (462 aa)
STRN4Striatin-4 isoform X2. (816 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC112907617Rho-related GTP-binding protein RhoG-like. (226 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (696 aa)
ENSVVUP00000004522annotation not available (66 aa)
ENSVVUP00000004929annotation not available (69 aa)
LOC112926139Tyrosine-protein phosphatase non-receptor type 11-like. (612 aa)
ENSVVUP00000005393annotation not available (155 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (575 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (187 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FYNTyrosine-protein kinase. (537 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1135 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (493 aa)
GAB1GRB2-associated-binding protein 1. (720 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (749 aa)
ERBB4Receptor protein-tyrosine kinase. (1249 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1026 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (735 aa)
LOC112918532WD repeat-containing protein 49-like. (539 aa)
EGFRReceptor protein-tyrosine kinase. (1154 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (781 aa)
HBEGFProheparin-binding EGF-like growth factor. (225 aa)
FRS2Fibroblast growth factor receptor substrate 2 isoform X1. (508 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (406 aa)
IER3Radiation-inducible immediate-early gene IEX-1. (156 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
FGFR2Fibroblast growth factor receptor. (866 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (906 aa)
ENSVVUP00000016557annotation not available (199 aa)
IL1RL1Interleukin-1 receptor-like 1. (557 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2. (570 aa)
ENSVVUP00000017517annotation not available (118 aa)
PIP5KL1Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1. (500 aa)
FAM102AProtein FAM102A. (380 aa)
IL1RAPInterleukin-1 receptor accessory protein. (685 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
KLBBeta-klotho. (1037 aa)
AREGAmphiregulin. (253 aa)
EREGProepiregulin. (161 aa)
EPGNEpigen. (138 aa)
SRMSTyrosine-protein kinase. (885 aa)
LCKTyrosine-protein kinase. (249 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (656 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (477 aa)
ENSVVUP00000023156annotation not available (593 aa)
ICOSInducible T-cell costimulator. (208 aa)
CD28T-cell-specific surface glycoprotein CD28. (217 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1. (432 aa)
LOC112932177Serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1. (971 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X3. (1212 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1211 aa)
ENSVVUP00000024290annotation not available (257 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
CD276CD276 antigen. (585 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (864 aa)
STRNStriatin isoform X1. (808 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (691 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
VAV1Proto-oncogene vav. (846 aa)
IL33Interleukin-33. (263 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
ENSVVUP00000028266annotation not available (301 aa)
IRS2LOW QUALITY PROTEIN: insulin receptor substrate 2. (1423 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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