STRINGSTRING
RPA2 RPA2 POLA1 POLA1 PSMB10 PSMB10 PSMD4 PSMD4 PSMB4 PSMB4 ENSVVUP00000017628 ENSVVUP00000017628 PSMD8 PSMD8 CCNA2 CCNA2 ORC5 ORC5 PSMC2 PSMC2 PSMD6 PSMD6 CDK3 CDK3 ENSVVUP00000020720 ENSVVUP00000020720 MCM9 MCM9 PPP2R1B PPP2R1B PSMA7 PSMA7 RPA3 RPA3 CUL1 CUL1 PSMD13 PSMD13 CCNE1 CCNE1 LOC112932177 LOC112932177 PSMD7 PSMD7 MCM4 MCM4 CREBZF CREBZF RELCH RELCH PSMC1 PSMC1 KIAA2012 KIAA2012 MCM2 MCM2 PSMD14 PSMD14 PPP4R4 PPP4R4 ORC2 ORC2 ENSVVUP00000026875 ENSVVUP00000026875 PPP2CB PPP2CB PSMB5 PSMB5 PPP2R3C PPP2R3C PSMA6 PSMA6 ENSVVUP00000027737 ENSVVUP00000027737 PSMD11 PSMD11 CDC7 CDC7 PRIM1 PRIM1 PPP2CA PPP2CA SKP1 SKP1 RPA1 RPA1 LOC112913400 LOC112913400 ENSVVUP00000029975 ENSVVUP00000029975 ENSVVUP00000030237 ENSVVUP00000030237 CDK2 CDK2 CCNH CCNH FNBP4 FNBP4 MCM7 MCM7 MCM8 MCM8 PSMC3 PSMC3 MCM5 MCM5 PSME3 PSME3 ENSVVUP00000033526 ENSVVUP00000033526 ENSVVUP00000033527 ENSVVUP00000033527 LOC112910913 LOC112910913 ENSVVUP00000033877 ENSVVUP00000033877 PSMB8 PSMB8 PSMB9 PSMB9 CDC45 CDC45 ENSVVUP00000035544 ENSVVUP00000035544 PSMD1 PSMD1 WEE1 WEE1 UBC UBC ENSVVUP00000036620 ENSVVUP00000036620 CDKN1A CDKN1A AKT3 AKT3 CCNA1 CCNA1 POLA2 POLA2 PSMB6 PSMB6 WEE2 WEE2 RB1 RB1 ENSVVUP00000040094 ENSVVUP00000040094 PSME1 PSME1 PSME2 PSME2 ENSVVUP00000041103 ENSVVUP00000041103 MNAT1 MNAT1 PSMA3 PSMA3 PSMC6 PSMC6 CDC25A CDC25A POLE2 POLE2 MCM3 MCM3 PSMB2 PSMB2 CDC6 CDC6 ENSVVUP00000001281 ENSVVUP00000001281 DBF4 DBF4 PSMD3 PSMD3 CKS2 CKS2 CKS1B CKS1B ORC6 ORC6 PSMB3 PSMB3 ENSVVUP00000003182 ENSVVUP00000003182 GMNN GMNN PSMA5 PSMA5 CCNE2 CCNE2 AKT1 AKT1 POLE3 POLE3 CDKN1C CDKN1C CDT1 CDT1 CABLES1 CABLES1 POLE4 POLE4 ENSVVUP00000005276 ENSVVUP00000005276 LOC112923316 LOC112923316 ENSVVUP00000005393 ENSVVUP00000005393 ENSVVUP00000005490 ENSVVUP00000005490 ORC1 ORC1 CDKN1B CDKN1B CCND1 CCND1 LOC112919437 LOC112919437 MCM10 MCM10 AKT2 AKT2 PPP2R3A PPP2R3A PSMC4 PSMC4 PSMC5 PSMC5 PSMD12 PSMD12 POLE POLE PSMA2 PSMA2 CDK7 CDK7 PSMB1 PSMB1 ENSVVUP00000009448 ENSVVUP00000009448 MCM6 MCM6 ENSVVUP00000010304 ENSVVUP00000010304 PSMA4 PSMA4 UBA52 UBA52 PSMF1 PSMF1 PPP2R3B PPP2R3B TM4SF19 TM4SF19 PRIM2 PRIM2 ENSVVUP00000012574 ENSVVUP00000012574 PSMB7 PSMB7 RPS27A RPS27A MEIOB MEIOB PSMD10 PSMD10 ORC3 ORC3 ENSVVUP00000013849 ENSVVUP00000013849 ENSVVUP00000014607 ENSVVUP00000014607 SKP2 SKP2 ENSVVUP00000014764 ENSVVUP00000014764 ORC4 ORC4 PPP2R1A PPP2R1A PPP4R1 PPP4R1 ENSVVUP00000016245 ENSVVUP00000016245 PSMD5 PSMD5 ENSVVUP00000016277 ENSVVUP00000016277 PSMD2 PSMD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA2Replication protein A 32 kDa subunit isoform X2. (269 aa)
POLA1DNA polymerase. (1467 aa)
PSMB10Proteasome subunit beta. (273 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (410 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ENSVVUP00000017628annotation not available (263 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (452 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (431 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (389 aa)
CDK3Cyclin-dependent kinase 3 isoform X3; Belongs to the protein kinase superfamily. (305 aa)
ENSVVUP00000020720annotation not available (254 aa)
MCM9DNA helicase MCM9 isoform X1; Belongs to the MCM family. (1141 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (656 aa)
PSMA7Proteasome endopeptidase complex. (243 aa)
RPA3Replication protein A 14 kDa subunit. (245 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (395 aa)
LOC112932177Serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1. (971 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (324 aa)
MCM4DNA helicase; Belongs to the MCM family. (865 aa)
CREBZFCREB/ATF bZIP transcription factor isoform X1. (369 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X3. (1212 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (453 aa)
KIAA2012Uncharacterized protein KIAA2012 homolog. (1168 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (864 aa)
ORC2Origin recognition complex subunit 2. (574 aa)
ENSVVUP00000026875annotation not available (107 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
PSMB5Proteasome subunit beta. (277 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
PSMA6Proteasome subunit alpha type. (228 aa)
ENSVVUP00000027737annotation not available (222 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11 isoform X1. (410 aa)
CDC7Cell division cycle 7-related protein kinase. (576 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (418 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
LOC112913400Protein DBF4 homolog A. (629 aa)
ENSVVUP00000029975annotation not available (85 aa)
ENSVVUP00000030237annotation not available (144 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CCNHLOW QUALITY PROTEIN: cyclin-H; Belongs to the cyclin family. (322 aa)
FNBP4LOW QUALITY PROTEIN: formin-binding protein 4. (1022 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (653 aa)
MCM8DNA helicase MCM8; Belongs to the MCM family. (868 aa)
PSMC326S proteasome regulatory subunit 6A isoform X2; Belongs to the AAA ATPase family. (581 aa)
MCM5DNA helicase; Belongs to the MCM family. (763 aa)
PSME3Proteasome activator complex subunit 3. (247 aa)
ENSVVUP00000033526annotation not available (137 aa)
ENSVVUP00000033527annotation not available (166 aa)
LOC112910913Ubiquitin-like. (77 aa)
ENSVVUP00000033877annotation not available (238 aa)
PSMB8Proteasome subunit beta. (306 aa)
PSMB9Proteasome subunit beta. (209 aa)
CDC45Cell division control protein 45 homolog. (569 aa)
ENSVVUP00000035544annotation not available (382 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (1037 aa)
WEE1Wee1-like protein kinase isoform X1. (627 aa)
UBCpolyubiquitin-C. (190 aa)
ENSVVUP00000036620annotation not available (157 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (586 aa)
PSMB6Proteasome subunit beta. (239 aa)
WEE2Wee1-like protein kinase. (566 aa)
RB1Retinoblastoma-associated protein. (928 aa)
ENSVVUP00000040094annotation not available (128 aa)
PSME1Proteasome activator complex subunit 1. (279 aa)
PSME2Proteasome activator complex subunit 2 isoform X1. (239 aa)
ENSVVUP00000041103annotation not available (105 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (327 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC626S proteasome regulatory subunit 10B isoform X1; Belongs to the AAA ATPase family. (403 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (524 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (531 aa)
MCM3DNA helicase; Belongs to the MCM family. (825 aa)
PSMB2Proteasome subunit beta. (189 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (516 aa)
ENSVVUP00000001281annotation not available (486 aa)
DBF4Activator of S phase kinase. (79 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (534 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ORC6Origin recognition complex subunit 6. (392 aa)
PSMB3Proteasome subunit beta. (196 aa)
ENSVVUP00000003182annotation not available (261 aa)
GMNNGeminin. (250 aa)
PSMA5Proteasome subunit alpha type. (264 aa)
CCNE2G1/S-specific cyclin-E2 isoform X2; Belongs to the cyclin family. (404 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (306 aa)
CDKN1CCyclin-dependent kinase inhibitor 1C. (165 aa)
CDT1DNA replication factor Cdt1. (512 aa)
CABLES1CDK5 and ABL1 enzyme substrate 1. (547 aa)
POLE4DNA polymerase epsilon subunit 4. (118 aa)
ENSVVUP00000005276annotation not available (161 aa)
LOC112923316Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (263 aa)
ENSVVUP00000005393annotation not available (155 aa)
ENSVVUP00000005490annotation not available (72 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (386 aa)
LOC112919437Proteasome subunit alpha type-1-like. (265 aa)
MCM10Protein MCM10 homolog. (875 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1152 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMC526S proteasome regulatory subunit 8 isoform X1; Belongs to the AAA ATPase family. (406 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X1. (456 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2279 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (348 aa)
PSMB1Proteasome subunit beta. (294 aa)
ENSVVUP00000009448annotation not available (262 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
ENSVVUP00000010304annotation not available (270 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
UBA52ubiquitin-60S ribosomal protein L40. (231 aa)
PSMF1Proteasome inhibitor PI31 subunit isoform X1. (418 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (569 aa)
TM4SF19Transmembrane 4 L6 family member 19. (209 aa)
PRIM2DNA primase large subunit. (469 aa)
ENSVVUP00000012574annotation not available (262 aa)
PSMB7Proteasome subunit beta. (239 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
MEIOBMeiosis-specific with OB domain-containing protein. (471 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
ORC3Origin recognition complex subunit 3 isoform X1. (772 aa)
ENSVVUP00000013849annotation not available (54 aa)
ENSVVUP00000014607annotation not available (200 aa)
SKP2S-phase kinase-associated protein 2. (436 aa)
ENSVVUP00000014764annotation not available (139 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (906 aa)
ENSVVUP00000016245annotation not available (152 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (461 aa)
ENSVVUP00000016277annotation not available (152 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (10%) [HD]