(47 nodes) Platelet Aggregation (Plug Formation) network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLN1	Talin-1 isoform X1. (2562 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (427 aa)
	SYK	Tyrosine-protein kinase. (610 aa)
	CRK	Adapter molecule crk isoform X1. (285 aa)
	EFS	Embryonal Fyn-associated substrate isoform X3. (682 aa)
	SOS1	Son of sevenless homolog 1 isoform X1. (1333 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	GP9	Platelet glycoprotein IX. (177 aa)
	ENSVVUP00000024552	annotation not available (118 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3 isoform X2. (299 aa)
	TLN2	Talin-2 isoform X2. (2556 aa)
	ENSVVUP00000024533	annotation not available (202 aa)
	ITGA2B	Integrin alpha-IIb; Belongs to the integrin alpha chain family. (1037 aa)
	CASS4	Cas scaffolding protein family member 4. (809 aa)
	GRB2	Growth factor receptor-bound protein 2. (351 aa)
	MFSD8	Major facilitator superfamily domain-containing protein 8 isoform X1. (519 aa)
	THPO	Thrombopoietin isoform X1. (409 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4 isoform X2. (1037 aa)
	PTK2	Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1059 aa)
	COL1A2	Collagen alpha-2(I) chain. (1274 aa)
	RAP1A	Ras-related protein Rap-1A. (336 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor-like 1. (456 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (730 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B. (1220 aa)
	SHC1	SHC-transforming protein 1 isoform X1. (583 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	NEDD9	Enhancer of filamentation 1 isoform X2. (834 aa)
	COL1A1	Collagen alpha-1(I) chain. (1288 aa)
	TLNRD1	Talin rod domain-containing protein 1. (342 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	ADRA2C	alpha-2C adrenergic receptor. (297 aa)
	MPL	Thrombopoietin receptor. (628 aa)
	FN1	Fibronectin. (2267 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
	APBB1IP	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein. (663 aa)
	RAP1B	Ras-related protein Rap-1b. (184 aa)
	RAPH1	LOW QUALITY PROTEIN: ras-associated and pleckstrin homology domains-containing protein 1. (1277 aa)
	RASGRP2	RAS guanyl-releasing protein 2 isoform X1. (575 aa)
	SRC	Tyrosine-protein kinase. (536 aa)
	FNDC3A	Fibronectin type-III domain-containing protein 3A isoform X1. (1199 aa)
	GP1BA	LOW QUALITY PROTEIN: platelet glycoprotein Ib alpha chain. (642 aa)
	ADRA2B	alpha-2B adrenergic receptor. (500 aa)
	RASGRP1	LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1. (748 aa)
	FGB	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (495 aa)
	FGA	Fibrinogen alpha chain. (782 aa)
	FGG	Fibrinogen gamma chain isoform X2. (437 aa)
	BCAR1	Breast cancer anti-estrogen resistance protein 1 isoform X2. (964 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA2B	ADRA2C	ENSVVUP00000038285	ENSVVUP00000010754	alpha-2B adrenergic receptor.	alpha-2C adrenergic receptor.	0.462
ADRA2C	ADRA2B	ENSVVUP00000010754	ENSVVUP00000038285	alpha-2C adrenergic receptor.	alpha-2B adrenergic receptor.	0.462
AKT1	CSK	ENSVVUP00000004067	ENSVVUP00000025392	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.503
AKT1	PDPK1	ENSVVUP00000004067	ENSVVUP00000012237	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide-dependent protein kinase 1 isoform X1.	0.918
AKT1	SRC	ENSVVUP00000004067	ENSVVUP00000041150	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.592
APBB1IP	BCAR1	ENSVVUP00000012326	ENSVVUP00000033604	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Breast cancer anti-estrogen resistance protein 1 isoform X2.	0.543
APBB1IP	CRK	ENSVVUP00000012326	ENSVVUP00000029602	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Adapter molecule crk isoform X1.	0.618
APBB1IP	CSK	ENSVVUP00000012326	ENSVVUP00000025392	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Tyrosine-protein kinase.	0.471
APBB1IP	GRB2	ENSVVUP00000012326	ENSVVUP00000015427	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Growth factor receptor-bound protein 2.	0.671
APBB1IP	ITGB3	ENSVVUP00000012326	ENSVVUP00000007139	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Integrin beta; Belongs to the integrin beta chain family.	0.452
APBB1IP	NEDD9	ENSVVUP00000012326	ENSVVUP00000005116	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Enhancer of filamentation 1 isoform X2.	0.471
APBB1IP	PTK2	ENSVVUP00000012326	ENSVVUP00000019828	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.487
APBB1IP	PTPN1	ENSVVUP00000012326	ENSVVUP00000030722	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Tyrosine-protein phosphatase non-receptor type.	0.533
APBB1IP	RAP1A	ENSVVUP00000012326	ENSVVUP00000022154	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Ras-related protein Rap-1A.	0.996
APBB1IP	RAP1B	ENSVVUP00000012326	ENSVVUP00000013927	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Ras-related protein Rap-1b.	0.996
APBB1IP	SHC1	ENSVVUP00000012326	ENSVVUP00000002434	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	SHC-transforming protein 1 isoform X1.	0.564
APBB1IP	SOS1	ENSVVUP00000012326	ENSVVUP00000025481	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Son of sevenless homolog 1 isoform X1.	0.514
APBB1IP	SRC	ENSVVUP00000012326	ENSVVUP00000041150	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Tyrosine-protein kinase.	0.437
APBB1IP	SYK	ENSVVUP00000012326	ENSVVUP00000030581	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Tyrosine-protein kinase.	0.671
APBB1IP	TLN1	ENSVVUP00000012326	ENSVVUP00000032230	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein.	Talin-1 isoform X1.	0.976