STRINGSTRING
AGER AGER TRAF3 TRAF3 IKBKB IKBKB LRRC34 LRRC34 LRRC31 LRRC31 LRRC45 LRRC45 FOSL2 FOSL2 RIPK2 RIPK2 TIFA TIFA ALPK1 ALPK1 MAPKAPK2 MAPKAPK2 LRRC74A LRRC74A NFKB2 NFKB2 LOC112926139 LOC112926139 ENSVVUP00000005393 ENSVVUP00000005393 USP14 USP14 FADD FADD TAB2 TAB2 ENSVVUP00000007041 ENSVVUP00000007041 LOC112925668 LOC112925668 LRRC14 LRRC14 FOS FOS TONSL TONSL ENSVVUP00000007999 ENSVVUP00000007999 LOC112921655 LOC112921655 LRRC71 LRRC71 NFKBIB NFKBIB NLRP13 NLRP13 NLRP9 NLRP9 TRAF6 TRAF6 LOC112928967 LOC112928967 TAB3 TAB3 UBA52 UBA52 UBE2D1 UBE2D1 TICAM1 TICAM1 VWC2L VWC2L NFKB1 NFKB1 UBE2D3 UBE2D3 MAP2K6 MAP2K6 HMGB1 HMGB1 TRAF5 TRAF5 RPS27A RPS27A ENSVVUP00000014079 ENSVVUP00000014079 BIRC3 BIRC3 BIRC2 BIRC2 ENSVVUP00000014764 ENSVVUP00000014764 PPP2R1A PPP2R1A DUSP6 DUSP6 TLR4 TLR4 ENSVVUP00000016091 ENSVVUP00000016091 PPP4R1 PPP4R1 CREB1 CREB1 RPS6KA1 RPS6KA1 ATF2 ATF2 ENSVVUP00000017517 ENSVVUP00000017517 CD14 CD14 RPS6KA3 RPS6KA3 LOC112932868 LOC112932868 MAPK10 MAPK10 IKBKE IKBKE MAP3K20-2 MAP3K20-2 MAP3K20 MAP3K20 MAP3K7 MAP3K7 TAB1 TAB1 TBK1 TBK1 PPP2R1B PPP2R1B SARM1 SARM1 NLRP6 NLRP6 LOC112932177 LOC112932177 ENSVVUP00000023416 ENSVVUP00000023416 IRF7 IRF7 DUSP3 DUSP3 ELK1 ELK1 ENSVVUP00000023942 ENSVVUP00000023942 RELCH RELCH ENSVVUP00000024290 ENSVVUP00000024290 N4BP1 N4BP1 ENSVVUP00000024657 ENSVVUP00000024657 RPS6KA5 RPS6KA5 TANK TANK PPP4R4 PPP4R4 CASP8 CASP8 RIPK1 RIPK1 NOD2 NOD2 LY96 LY96 ENSVVUP00000026712 ENSVVUP00000026712 DUSP4 DUSP4 PPP2CB PPP2CB ENSVVUP00000027142 ENSVVUP00000027142 NFKBIA NFKBIA ENSVVUP00000027292 ENSVVUP00000027292 VRK3 VRK3 MAPK1 MAPK1 S100B S100B NKIRAS2 NKIRAS2 MAPK8 MAPK8 NOD1 NOD1 PPP2CA PPP2CA ENSVVUP00000029422 ENSVVUP00000029422 RPS6KA2 RPS6KA2 LRRC74B LRRC74B UBE2V1 UBE2V1 LOC112917600 LOC112917600 IRF3 IRF3 MAPK15 MAPK15 USP18 USP18 NLRX1 NLRX1 FNBP4 FNBP4 CPNE2 CPNE2 IRAK2 IRAK2 TNIP2 TNIP2 APP APP LOC112910913 LOC112910913 CREB5 CREB5 CHUK CHUK MAPK11 MAPK11 UBC UBC ATF1 ATF1 MAPK3 MAPK3 TRAF2 TRAF2 MAPK14 MAPK14 ENSVVUP00000037430 ENSVVUP00000037430 DUSP7 DUSP7 MAPK9 MAPK9 MAP2K7 MAP2K7 RELA RELA PPP2R5D PPP2R5D ATF7 ATF7 NKIRAS1 NKIRAS1 S100A12 S100A12 MAPKAPK3 MAPKAPK3 ENSVVUP00000040094 ENSVVUP00000040094 RIPK3 RIPK3 KHNYN KHNYN IKBKG IKBKG IRAK1 IRAK1 RPS6KA4 RPS6KA4 MAP2K4 MAP2K4 MAPK7 MAPK7 MAP2K3 MAP2K3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGERAdvanced glycosylation end product-specific receptor. (405 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (782 aa)
LRRC34Leucine-rich repeat-containing protein 34. (402 aa)
LRRC31Leucine-rich repeat-containing protein 31 isoform X1. (457 aa)
LRRC45Leucine-rich repeat-containing protein 45. (670 aa)
FOSL2Fos-related antigen 2. (325 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
TIFATRAF-interacting protein with FHA domain-containing protein A. (163 aa)
ALPK1Alpha-protein kinase 1 isoform X1. (1237 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (429 aa)
LRRC74ALeucine-rich repeat-containing protein 74A. (489 aa)
NFKB2LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit. (863 aa)
LOC112926139Tyrosine-protein phosphatase non-receptor type 11-like. (612 aa)
ENSVVUP00000005393annotation not available (155 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (545 aa)
FADDFAS-associated death domain protein. (220 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
ENSVVUP00000007041annotation not available (62 aa)
LOC112925668High mobility group protein B1-like. (207 aa)
LRRC14Leucine-rich repeat-containing protein 14 isoform X1. (492 aa)
FOSProto-oncogene c-Fos. (380 aa)
TONSLTonsoku-like protein. (1165 aa)
ENSVVUP00000007999annotation not available (96 aa)
LOC112921655Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LRRC71Leucine-rich repeat-containing protein 71. (536 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
NLRP13NACHT, LRR and PYD domains-containing protein 13-like. (1029 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9. (995 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
LOC112928967Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1. (717 aa)
UBA52ubiquitin-60S ribosomal protein L40. (231 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (693 aa)
VWC2LVon Willebrand factor C domain-containing protein 2-like. (222 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3. (175 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
HMGB1High mobility group protein B1. (215 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
ENSVVUP00000014079annotation not available (196 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (459 aa)
ENSVVUP00000014764annotation not available (139 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (833 aa)
ENSVVUP00000016091annotation not available (109 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (906 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
ENSVVUP00000017517annotation not available (118 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
LOC112932868Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (765 aa)
MAP3K20-2Mitogen-activated protein kinase kinase kinase 20 isoform X2. (487 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X1. (509 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (502 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (820 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (656 aa)
SARM1Sterile alpha and TIR motif-containing protein 1. (761 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (875 aa)
LOC112932177Serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1. (971 aa)
ENSVVUP00000023416Ubiquitin-conjugating enzyme E2 N-like. (105 aa)
IRF7Interferon regulatory factor 7. (90 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
ENSVVUP00000023942Ubiquitin-conjugating enzyme E2 N-like. (93 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X3. (1212 aa)
ENSVVUP00000024290annotation not available (257 aa)
N4BP1NEDD4-binding protein 1. (1009 aa)
ENSVVUP00000024657annotation not available (103 aa)
RPS6KA5Ribosomal protein S6 kinase. (913 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (475 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1. (864 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (397 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (732 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1043 aa)
LY96Lymphocyte antigen 96. (160 aa)
ENSVVUP00000026712annotation not available (255 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (435 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
ENSVVUP00000027142annotation not available (182 aa)
NFKBIANF-kappa-B inhibitor alpha. (327 aa)
ENSVVUP00000027292Ubiquitin-conjugating enzyme E2 N-like. (146 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X2. (458 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2. (209 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ENSVVUP00000029422Ubiquitin-conjugating enzyme E2 N-like. (89 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
LRRC74BLeucine-rich repeat-containing protein 74B. (396 aa)
UBE2V1Ubiquitin-conjugating enzyme E2 variant 1 isoform X3. (105 aa)
LOC112917600Ubiquitin-conjugating enzyme E2 N-like; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
IRF3Interferon regulatory factor 3 isoform X1. (428 aa)
MAPK15Mitogen-activated protein kinase. (601 aa)
USP18Ubl carboxyl-terminal hydrolase 18 isoform X1; Belongs to the peptidase C19 family. (339 aa)
NLRX1NLR family member X1 isoform X1. (975 aa)
FNBP4LOW QUALITY PROTEIN: formin-binding protein 4. (1022 aa)
CPNE2Protein NLRC5. (1868 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (598 aa)
TNIP2TNFAIP3-interacting protein 2 isoform X1. (435 aa)
APPAmyloid-beta A4 protein isoform X1. (770 aa)
LOC112910913Ubiquitin-like. (77 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (548 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
MAPK11Mitogen-activated protein kinase. (332 aa)
UBCpolyubiquitin-C. (190 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X2. (270 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (533 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSVVUP00000037430annotation not available (99 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (464 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X2. (439 aa)
RELATranscription factor p65 isoform X2. (542 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (604 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7 isoform X1. (483 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1. (206 aa)
S100A12Protein S100; Belongs to the S-100 family. (110 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa)
ENSVVUP00000040094annotation not available (128 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (486 aa)
KHNYNProtein KHNYN. (669 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (551 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (709 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (455 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (397 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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