19 items (Vulpes vulpes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	IRAK2	Interleukin-1 receptor-associated kinase-like 2. (598 aa)
	ENSVVUP00000026712	annotation not available (255 aa)
	LOC112910913	Ubiquitin-like. (77 aa)
	TAB2	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	TAB3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1. (717 aa)
	UBA52	ubiquitin-60S ribosomal protein L40. (231 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (693 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (156 aa)
	ENSVVUP00000014764	annotation not available (139 aa)
	TLR4	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (833 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
	MAP3K20-2	Mitogen-activated protein kinase kinase kinase 20 isoform X2. (487 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase 20 isoform X1. (509 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	TAB1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (502 aa)
	ENSVVUP00000040094	annotation not available (128 aa)
	UBC	polyubiquitin-C. (190 aa)
	LY96	Lymphocyte antigen 96. (160 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD14	IRAK2	ENSVVUP00000017573	ENSVVUP00000032260	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Interleukin-1 receptor-associated kinase-like 2.	0.417
CD14	LY96	ENSVVUP00000017573	ENSVVUP00000026529	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Lymphocyte antigen 96.	0.983
CD14	MAP3K7	ENSVVUP00000017573	ENSVVUP00000019114	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.407
CD14	TLR4	ENSVVUP00000017573	ENSVVUP00000015867	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family.	0.927
CD14	TRAF6	ENSVVUP00000017573	ENSVVUP00000009350	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.447
ENSVVUP00000014764	ENSVVUP00000026712	ENSVVUP00000014764	ENSVVUP00000026712	annotation not available	annotation not available	0.437
ENSVVUP00000014764	ENSVVUP00000040094	ENSVVUP00000014764	ENSVVUP00000040094	annotation not available	annotation not available	0.985
ENSVVUP00000014764	IRAK2	ENSVVUP00000014764	ENSVVUP00000032260	annotation not available	Interleukin-1 receptor-associated kinase-like 2.	0.464
ENSVVUP00000014764	LOC112910913	ENSVVUP00000014764	ENSVVUP00000033800	annotation not available	Ubiquitin-like.	0.986
ENSVVUP00000014764	LY96	ENSVVUP00000014764	ENSVVUP00000026529	annotation not available	Lymphocyte antigen 96.	0.428
ENSVVUP00000014764	MAP3K20	ENSVVUP00000014764	ENSVVUP00000018721	annotation not available	Mitogen-activated protein kinase kinase kinase 20 isoform X1.	0.450
ENSVVUP00000014764	MAP3K20-2	ENSVVUP00000014764	ENSVVUP00000018708	annotation not available	Mitogen-activated protein kinase kinase kinase 20 isoform X2.	0.450
ENSVVUP00000014764	MAP3K7	ENSVVUP00000014764	ENSVVUP00000019114	annotation not available	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.500
ENSVVUP00000014764	TAB1	ENSVVUP00000014764	ENSVVUP00000019699	annotation not available	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1.	0.460
ENSVVUP00000014764	TAB2	ENSVVUP00000014764	ENSVVUP00000006546	annotation not available	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.	0.823
ENSVVUP00000014764	TAB3	ENSVVUP00000014764	ENSVVUP00000010363	annotation not available	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1.	0.752
ENSVVUP00000014764	TRAF6	ENSVVUP00000014764	ENSVVUP00000009350	annotation not available	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.987
ENSVVUP00000014764	UBA52	ENSVVUP00000014764	ENSVVUP00000010830	annotation not available	ubiquitin-60S ribosomal protein L40.	0.985
ENSVVUP00000014764	UBC	ENSVVUP00000014764	ENSVVUP00000035962	annotation not available	polyubiquitin-C.	0.986
ENSVVUP00000026712	ENSVVUP00000014764	ENSVVUP00000026712	ENSVVUP00000014764	annotation not available	annotation not available	0.437