STRINGSTRING
IKBKB IKBKB IL6 IL6 TYMS TYMS ABCC4 ABCC4 ABCC5 ABCC5 ABCG2 ABCG2 ATIC ATIC NFKB1 NFKB1 ABCC3 ABCC3 FPGS FPGS SLC46A1 SLC46A1 SHMT2 SHMT2 GGH GGH ABCC1 ABCC1 TNF TNF GART GART SLC19A1 SLC19A1 ABCC2 ABCC2 CHUK CHUK FOLR2 FOLR2 LOC112928755 LOC112928755 RELA RELA ALOX12 ALOX12 MTHFR MTHFR IL1B IL1B IKBKG IKBKG SHMT1 SHMT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (782 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (207 aa)
TYMSThymidylate synthase isoform X1. (314 aa)
ABCC4Multidrug resistance-associated protein 4. (1318 aa)
ABCC5Multidrug resistance-associated protein 5 isoform X1. (1485 aa)
ABCG2ATP-binding cassette sub-family G member 2. (650 aa)
ATICBifunctional purine biosynthesis protein PURH. (533 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
ABCC3Canalicular multispecific organic anion transporter 2. (1326 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (588 aa)
SLC46A1Proton-coupled folate transporter. (459 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (505 aa)
GGHFolate gamma-glutamyl hydrolase. (318 aa)
ABCC1Multidrug resistance-associated protein 1. (1465 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
SLC19A1Folate transporter 1. (500 aa)
ABCC2Canalicular multispecific organic anion transporter 1. (1544 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
FOLR2Folate receptor beta. (213 aa)
LOC112928755LOW QUALITY PROTEIN: folate receptor alpha-like. (241 aa)
RELATranscription factor p65 isoform X2. (542 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (685 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (265 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (486 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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