(8 nodes) Non-homologous end-joining network (Vulpes vulpes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (576 aa)
	XRCC6	LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6. (593 aa)
	DCLRE1C	Protein artemis isoform X2. (654 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
	PRKDC	DNA-dependent protein kinase catalytic subunit isoform X2; Belongs to the PI3/PI4-kinase family. (4136 aa)
	DNTT	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (511 aa)
	RAD50	DNA repair protein RAD50 isoform X1. (1312 aa)
	NHEJ1	Non-homologous end-joining factor 1. (313 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCLRE1C	DNTT	ENSVVUP00000006905	ENSVVUP00000031537	Protein artemis isoform X2.	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	0.491
DCLRE1C	MRE11	ENSVVUP00000006905	ENSVVUP00000015733	Protein artemis isoform X2.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.825
DCLRE1C	NHEJ1	ENSVVUP00000006905	ENSVVUP00000035890	Protein artemis isoform X2.	Non-homologous end-joining factor 1.	0.414
DCLRE1C	POLL	ENSVVUP00000006905	ENSVVUP00000000825	Protein artemis isoform X2.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.637
DCLRE1C	PRKDC	ENSVVUP00000006905	ENSVVUP00000022479	Protein artemis isoform X2.	DNA-dependent protein kinase catalytic subunit isoform X2; Belongs to the PI3/PI4-kinase family.	0.958
DCLRE1C	RAD50	ENSVVUP00000006905	ENSVVUP00000034039	Protein artemis isoform X2.	DNA repair protein RAD50 isoform X1.	0.635
DCLRE1C	XRCC6	ENSVVUP00000006905	ENSVVUP00000004450	Protein artemis isoform X2.	LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6.	0.863
DNTT	DCLRE1C	ENSVVUP00000031537	ENSVVUP00000006905	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Protein artemis isoform X2.	0.491
DNTT	POLL	ENSVVUP00000031537	ENSVVUP00000000825	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.442
DNTT	PRKDC	ENSVVUP00000031537	ENSVVUP00000022479	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA-dependent protein kinase catalytic subunit isoform X2; Belongs to the PI3/PI4-kinase family.	0.523
DNTT	XRCC6	ENSVVUP00000031537	ENSVVUP00000004450	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6.	0.453
MRE11	DCLRE1C	ENSVVUP00000015733	ENSVVUP00000006905	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Protein artemis isoform X2.	0.825
MRE11	PRKDC	ENSVVUP00000015733	ENSVVUP00000022479	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA-dependent protein kinase catalytic subunit isoform X2; Belongs to the PI3/PI4-kinase family.	0.820
MRE11	RAD50	ENSVVUP00000015733	ENSVVUP00000034039	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	DNA repair protein RAD50 isoform X1.	0.999
MRE11	XRCC6	ENSVVUP00000015733	ENSVVUP00000004450	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6.	0.902
NHEJ1	DCLRE1C	ENSVVUP00000035890	ENSVVUP00000006905	Non-homologous end-joining factor 1.	Protein artemis isoform X2.	0.414
NHEJ1	POLL	ENSVVUP00000035890	ENSVVUP00000000825	Non-homologous end-joining factor 1.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.443
NHEJ1	PRKDC	ENSVVUP00000035890	ENSVVUP00000022479	Non-homologous end-joining factor 1.	DNA-dependent protein kinase catalytic subunit isoform X2; Belongs to the PI3/PI4-kinase family.	0.500
NHEJ1	XRCC6	ENSVVUP00000035890	ENSVVUP00000004450	Non-homologous end-joining factor 1.	LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6.	0.555
POLL	DCLRE1C	ENSVVUP00000000825	ENSVVUP00000006905	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	Protein artemis isoform X2.	0.637