STRINGSTRING
GNB5 GNB5 CXCR3 CXCR3 CCR7 CCR7 VAV3 VAV3 IKBKB IKBKB PARD3 PARD3 ROCK2 ROCK2 GNAQ GNAQ BRAF BRAF SHC1 SHC1 GNAI3 GNAI3 GNG8 GNG8 GNG7 GNG7 GNGT2 GNGT2 PTK2B PTK2B ADCY5 ADCY5 ROCK1 ROCK1 ITK ITK GNB1 GNB1 PRKCZ PRKCZ PIK3CA PIK3CA GNB4 GNB4 FOXO3 FOXO3 PRKCB PRKCB LOC112912331 LOC112912331 CCR8 CCR8 CX3CR1 CX3CR1 AKT2 AKT2 CCR5 CCR5 CCR2 CCR2 CCR3 CCR3 CCR1 CCR1 XCR1 XCR1 CXCR6 CXCR6 CCR9 CCR9 NFKBIB NFKBIB PIK3R1 PIK3R1 CXCR4 CXCR4 LOC112914774 LOC112914774 JAK2 JAK2 LOC112922479 LOC112922479 LOC112922564 LOC112922564 GNG12 GNG12 HCK HCK NFKB1 NFKB1 GNG4 GNG4 NRAS NRAS GSK3A GSK3A RAP1B RAP1B JAK3 JAK3 GRK2 GRK2 GRK5 GRK5 GNB3 GNB3 GRB2 GRB2 GNG13 GNG13 FGR FGR GRK1 GRK1 PTK2 PTK2 PPBP PPBP CXCL8 CXCL8 NCF1 NCF1 ADCY3 ADCY3 RAF1 RAF1 GNGT1 GNGT1 RAC1 RAC1 GRK3 GRK3 RAP1A RAP1A ADCY9 ADCY9 SHC4 SHC4 ADCY8 ADCY8 HRAS HRAS CXCL14 CXCL14 ADCY2 ADCY2 LYN LYN SOS1 SOS1 GNAI1 GNAI1 ADCY6 ADCY6 NFKBIA NFKBIA VAV1 VAV1 LOC112918090 LOC112918090 LOC112918092 LOC112918092 LOC112918093 LOC112918093 LOC112918094 LOC112918094 LOC112918096 LOC112918096 CCL14 CCL14 CCL16 CCL16 CCL5 CCL5 MAPK1 MAPK1 TIAM1 TIAM1 CCL1 CCL1 LOC112918104 LOC112918104 CCL8 CCL8 CCL2 CCL2 CCL21 CCL21 LOC112927529 LOC112927529 CCL27 CCL27 PREX1 PREX1 CRKL CRKL CRK CRK CCR6 CCR6 STAT2 STAT2 PIK3CG PIK3CG CCR4 CCR4 SHC3 SHC3 PLCB4 PLCB4 STAT5B STAT5B PLCB1 PLCB1 GNB2 GNB2 CXCL10 CXCL10 CXCL9 CXCL9 CCL22 CCL22 CX3CL1 CX3CL1 CCL17 CCL17 PAK1 PAK1 RAC2 RAC2 STAT3 STAT3 CCL24 CCL24 CCL26 CCL26 PRKCD PRKCD GNG14 GNG14 CCR10 CCR10 CXCR5 CXCR5 BCAR1 BCAR1 ARRB1 ARRB1 CHUK CHUK CXCL13 CXCL13 CCL28 CCL28 CCL20 CCL20 MAPK3 MAPK3 GRK6 GRK6 GRK7 GRK7 STAT1 STAT1 AKT3 AKT3 PIK3CB PIK3CB PLCB2 PLCB2 PRKACA PRKACA CCL25 CCL25 RELA RELA CXCL16 CXCL16 ARRB2 ARRB2 GNAI2 GNAI2 PIK3R6 PIK3R6 PIK3R5 PIK3R5 ELMO1 ELMO1 RHOA RHOA PLCG1 PLCG1 ADCY4 ADCY4 SRC SRC IKBKG IKBKG GNG2 GNG2 RASGRP2 RASGRP2 BAD BAD PLCB3 PLCB3 SOS2 SOS2 GNG3 GNG3 PRKACB PRKACB CDC42 CDC42 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNB5Guanine nucleotide-binding protein subunit beta-5. (342 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (373 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (867 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (782 aa)
PARD3Partitioning defective 3 homolog. (1328 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1327 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (765 aa)
SHC1SHC-transforming protein 1 isoform X1. (583 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1366 aa)
ITKTyrosine-protein kinase. (625 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (557 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
FOXO3Forkhead box protein O3. (453 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LOC112912331Phosphoinositide phospholipase C. (690 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
CCR5C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CCR2C-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (372 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (403 aa)
CCR1C-C chemokine receptor type 1-like; Belongs to the G-protein coupled receptor 1 family. (355 aa)
XCR1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (330 aa)
CXCR6C-X-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
CCR9C-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family. (368 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LOC112922479C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LOC112922564C-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (367 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
HCKTyrosine-protein kinase. (628 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (105 aa)
NRASGTPase NRas. (189 aa)
GSK3AGlycogen synthase kinase-3 alpha. (446 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
JAK3Tyrosine-protein kinase. (1106 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
GRK5G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (590 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (270 aa)
FGRTyrosine-protein kinase. (527 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (564 aa)
PTK2Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1059 aa)
PPBPPlatelet basic protein-like. (116 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)
NCF1Neutrophil cytosol factor 1. (365 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1314 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (202 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (672 aa)
RAP1ARas-related protein Rap-1A. (336 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
SHC4SHC-transforming protein 4. (631 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
HRASGTPase HRas isoform X1. (189 aa)
CXCL14C-X-C motif chemokine 14. (99 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa)
LYNTyrosine-protein kinase. (512 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X2. (377 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
NFKBIANF-kappa-B inhibitor alpha. (327 aa)
VAV1Proto-oncogene vav. (846 aa)
LOC112918090C-C motif chemokine. (92 aa)
LOC112918092C-C motif chemokine. (93 aa)
LOC112918093C-C motif chemokine. (76 aa)
LOC112918094Regakine-1-like. (94 aa)
LOC112918096C-C motif chemokine 23-like isoform X1. (118 aa)
CCL14C-C motif chemokine. (96 aa)
CCL16C-C motif chemokine 16. (219 aa)
CCL5C-C motif chemokine. (91 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1591 aa)
CCL1C-C motif chemokine. (94 aa)
LOC112918104C-C motif chemokine. (190 aa)
CCL8C-C motif chemokine. (99 aa)
CCL2C-C motif chemokine. (101 aa)
CCL21C-C motif chemokine 21. (137 aa)
LOC112927529Uncharacterized protein LOC112927529. (87 aa)
CCL27C-C motif chemokine 27. (119 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1668 aa)
CRKLCrk-like protein. (303 aa)
CRKAdapter molecule crk isoform X1. (285 aa)
CCR6C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (376 aa)
STAT2Signal transducer and activator of transcription. (855 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1103 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
SHC3SHC-transforming protein 3. (289 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
STAT5BSignal transducer and activator of transcription. (789 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (372 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CXCL9C-X-C motif chemokine. (118 aa)
CCL22C-C motif chemokine. (93 aa)
CX3CL1Fractalkine. (451 aa)
CCL17C-C motif chemokine. (99 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (173 aa)
STAT3Signal transducer and activator of transcription. (791 aa)
CCL24C-C motif chemokine 24. (119 aa)
CCL26C-C motif chemokine. (94 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CCR10C-C chemokine receptor type 10; Belongs to the G-protein coupled receptor 1 family. (363 aa)
CXCR5C-X-C chemokine receptor type 5 isoform X1; Belongs to the G-protein coupled receptor 1 family. (372 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X2. (964 aa)
ARRB1Beta-arrestin-1 isoform X2. (422 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
CXCL13C-X-C motif chemokine. (110 aa)
CCL28C-C motif chemokine. (147 aa)
CCL20C-C motif chemokine 20. (97 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (679 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
CCL25C-C motif chemokine. (199 aa)
RELATranscription factor p65 isoform X2. (542 aa)
CXCL16C-X-C motif chemokine 16. (255 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (355 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (875 aa)
ELMO1Engulfment and cell motility protein 1 isoform X2. (823 aa)
RHOATransforming protein RhoA. (193 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
SRCTyrosine-protein kinase. (536 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (103 aa)
RASGRP2RAS guanyl-releasing protein 2 isoform X1. (575 aa)
BADBcl2-associated agonist of cell death. (157 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
SOS2Son of sevenless homolog 2. (1308 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
KRASGTPase KRas isoform X1. (418 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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