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| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | PPP2R2C | Protein phosphatase 2, regulatory subunit B, gamma isoform X1. (405 aa) |
| | ROCK2 | Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1327 aa) |
| | PLD1 | Phospholipase. (1075 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(Q) subunit alpha. (359 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (470 aa) |
| | CTSD | Cathepsin D; Belongs to the peptidase A1 family. (410 aa) |
| | ASAH2 | Neutral ceramidase. (219 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (466 aa) |
| | DEGS1 | Sphingolipid delta(4)-desaturase DES1. (323 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1366 aa) |
| | SPTLC2 | Serine palmitoyltransferase 2 isoform X1. (559 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. (557 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (750 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | GNA12 | Guanine nucleotide-binding protein subunit alpha-12. (359 aa) |
| | AKT2 | RAC-beta serine/threonine-protein kinase. (557 aa) |
| | PPP2R3A | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1152 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | ASAH1 | Acid ceramidase; Belongs to the acid ceramidase family. (375 aa) |
| | LOC112914774 | Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa) |
| | GNA13 | Guanine nucleotide-binding protein subunit alpha-13. (377 aa) |
| | CERS1 | Ceramide synthase 1 isoform X1. (310 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (493 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2. (398 aa) |
| | PPP2R3B | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (569 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1207 aa) |
| | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa) |
| | NRAS | GTPase NRas. (189 aa) |
| | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (313 aa) |
| | CERS2 | Ceramide synthase 2. (380 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A. (359 aa) |
| | OPRD1 | Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (363 aa) |
| | KNG1 | Kininogen-1. (429 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (529 aa) |
| | SPTLC3 | Serine palmitoyltransferase 3. (552 aa) |
| | CERS3 | Ceramide synthase 3. (396 aa) |
| | SPHK1 | Sphingosine kinase 1. (469 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (202 aa) |
| | FCER1G | High affinity immunoglobulin epsilon receptor subunit gamma. (90 aa) |
| | ADORA3 | Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (313 aa) |
| | FCER1A | High affinity immunoglobulin epsilon receptor subunit alpha. (220 aa) |
| | CERS6 | Ceramide synthase 6 isoform X1. (392 aa) |
| | HRAS | GTPase HRas isoform X1. (189 aa) |
| | S1PR5 | Sphingosine 1-phosphate receptor 5. (115 aa) |
| | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2. (365 aa) |
| | BCL2 | Apoptosis regulator Bcl-2. (125 aa) |
| | NSMAF | Protein FAN. (902 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X2. (377 aa) |
| | ABCC1 | Multidrug resistance-associated protein 1. (1465 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (279 aa) |
| | PPP2R3C | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (392 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (387 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (512 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (573 aa) |
| | S1PR1 | Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | S1PR3 | Sphingosine 1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | SPTLC1 | Serine palmitoyltransferase 1 isoform X1. (473 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (290 aa) |
| | GAB2 | GRB2-associated-binding protein 2. (666 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | BAX | Apoptosis regulator BAX isoform X2. (192 aa) |
| | SPHK2 | Sphingosine kinase 2 isoform X1. (674 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2. (173 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa) |
| | CERS5 | Ceramide synthase 5 isoform X1. (404 aa) |
| | CERS4 | Ceramide synthase 4 isoform X1. (395 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (348 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (332 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (533 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (413 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa) |
| | MS4A2 | High affinity immunoglobulin epsilon receptor subunit beta-like. (239 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (382 aa) |
| | RELA | Transcription factor p65 isoform X2. (542 aa) |
| | PLD2 | Phospholipase. (522 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (604 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa) |
| | BDKRB2 | B2 bradykinin receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (392 aa) |
| | DEGS2 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2. (324 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (355 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa) |
| | S1PR2 | Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | RHOA | Transforming protein RhoA. (193 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (498 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa) |
| | KRAS | GTPase KRas isoform X1. (418 aa) |
