STRINGSTRING
PLA2G4D PLA2G4D PLA2G4F PLA2G4F GRM6 GRM6 GRM3 GRM3 PLD1 PLD1 AGPAT4 AGPAT4 SHC1 SHC1 INS INS PIP5K1C PIP5K1C PTK2B PTK2B ADCY5 ADCY5 PIP5K1B PIP5K1B PIK3CA PIK3CA GRM1 GRM1 ARL17A ARL17A RALA RALA GNA12 GNA12 LOC112912331 LOC112912331 AKT2 AKT2 PIK3R1 PIK3R1 FYN FYN PRKCA PRKCA AGT AGT GRM8 GRM8 LOC112914774 LOC112914774 LOC112922479 LOC112922479 LOC112922564 LOC112922564 PDGFRB PDGFRB LPAR2 LPAR2 GNA13 GNA13 RHEB RHEB GAB1 GAB1 MAP2K2 MAP2K2 DGKB DGKB LOC112913297 LOC112913297 EGFR EGFR NRAS NRAS PTPN11 PTPN11 GRB2 GRB2 LPAR5 LPAR5 LOC112912529 LOC112912529 KITLG KITLG DGKE DGKE AGTR1 AGTR1 PLA2G4A PLA2G4A PIP5K1A PIP5K1A DGKQ DGKQ DGKG DGKG DNM1 DNM1 AVPR1B AVPR1B LPAR4 LPAR4 RAPGEF4 RAPGEF4 PDGFD PDGFD PDGFB PDGFB DNM3 DNM3 CXCL8 CXCL8 AVPR1A AVPR1A SPHK1 SPHK1 ADCY3 ADCY3 RAF1 RAF1 FCER1G FCER1G ADCY9 ADCY9 SHC4 SHC4 FCER1A FCER1A LOC112932168 LOC112932168 LOC112932169 LOC112932169 ADCY8 ADCY8 HRAS HRAS EGF EGF DNM2 DNM2 ADCY2 ADCY2 RAPGEF3 RAPGEF3 DGKK DGKK RALB RALB SOS1 SOS1 GRM5 GRM5 ADCY6 ADCY6 MAPK1 MAPK1 PIK3CG PIK3CG SHC3 SHC3 SYK SYK PLPP2 PLPP2 RRAS RRAS DGKA DGKA GAB2 GAB2 PLCB4 PLCB4 SPHK2 SPHK2 CYTH2 CYTH2 PLCB1 PLCB1 CYTH4 CYTH4 RRAS2 RRAS2 AGPAT3 AGPAT3 PDGFRA PDGFRA KIT KIT AGPAT1 AGPAT1 F2R F2R GRM7 GRM7 DGKD DGKD AVP AVP MAPK3 MAPK3 AGPAT2 AGPAT2 GRM4 GRM4 AKT3 AKT3 PIK3CB PIK3CB PLCB2 PLCB2 MRAS MRAS PLPP3 PLPP3 MS4A2 MS4A2 F2 F2 GRM2 GRM2 PLA2G4B PLA2G4B PLA2G4E PLA2G4E DGKZ DGKZ PLD2 PLD2 INSR INSR LPAR6 LPAR6 MTOR MTOR TSC1 TSC1 RALGDS RALGDS DGKH DGKH LPAR1 LPAR1 PIK3R6 PIK3R6 PIK3R5 PIK3R5 PDGFA PDGFA RHOA RHOA PLCG1 PLCG1 ADCY4 ADCY4 AGPAT5 AGPAT5 PLCB3 PLCB3 SOS2 SOS2 ARF6 ARF6 PTGFR PTGFR LPAR3 LPAR3 KRAS KRAS ARF1 ARF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G4DPhospholipase A2. (769 aa)
PLA2G4FPhospholipase A2. (863 aa)
GRM6Metabotropic glutamate receptor 6. (865 aa)
GRM3Metabotropic glutamate receptor 3. (879 aa)
PLD1Phospholipase. (1075 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2. (378 aa)
SHC1SHC-transforming protein 1 isoform X1. (583 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (696 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (575 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1190 aa)
ARL17AADP-ribosylation factor-like 17-like isoform X1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
RALARas-related protein Ral-A. (206 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (359 aa)
LOC112912331Phosphoinositide phospholipase C. (690 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FYNTyrosine-protein kinase. (537 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
GRM8Metabotropic glutamate receptor 8. (927 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
LOC112922479C-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LOC112922564C-X-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (367 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1135 aa)
LPAR2Lysophosphatidic acid receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (351 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (377 aa)
RHEBGTP-binding protein Rheb. (168 aa)
GAB1GRB2-associated-binding protein 1. (720 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (398 aa)
DGKBDiacylglycerol kinase beta isoform X1. (654 aa)
LOC112913297Metabotropic glutamate receptor 7-like. (189 aa)
EGFRReceptor protein-tyrosine kinase. (1154 aa)
NRASGTPase NRas. (189 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LOC112912529Platelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (127 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
DGKEDiacylglycerol kinase. (564 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PLA2G4APhospholipase A2. (749 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2. (570 aa)
DGKQDiacylglycerol kinase. (865 aa)
DGKGDiacylglycerol kinase. (790 aa)
DNM1Dynamin-1 isoform X9; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (845 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X2. (1037 aa)
PDGFDPlatelet-derived growth factor D isoform X2. (350 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
DNM3Dynamin-3 isoform X6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (401 aa)
SPHK1Sphingosine kinase 1. (469 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1314 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (90 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
SHC4SHC-transforming protein 4. (631 aa)
FCER1AHigh affinity immunoglobulin epsilon receptor subunit alpha. (220 aa)
LOC112932168Guanine nucleotide-binding protein G(S) subunit alpha isoform X6. (394 aa)
LOC112932169Neuroendocrine secretory protein 55. (247 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1254 aa)
HRASGTPase HRas isoform X1. (189 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1211 aa)
DNM2Dynamin-2 isoform X5; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (872 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1051 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (299 aa)
DGKKDiacylglycerol kinase. (1260 aa)
RALBRas-related protein Ral-B. (206 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
GRM5LOW QUALITY PROTEIN: metabotropic glutamate receptor 5. (1145 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1103 aa)
SHC3SHC-transforming protein 3. (289 aa)
SYKTyrosine-protein kinase. (610 aa)
PLPP2Phospholipid phosphatase 2. (351 aa)
RRASRas-related protein R-Ras. (218 aa)
DGKADiacylglycerol kinase. (717 aa)
GAB2GRB2-associated-binding protein 2. (666 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
SPHK2Sphingosine kinase 2 isoform X1. (674 aa)
CYTH2Cytohesin-2 isoform X2. (543 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
CYTH4Cytohesin-4. (394 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (177 aa)
AGPAT31-acyl-sn-glycerol-3-phosphate acyltransferase gamma. (376 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1111 aa)
KITMast/stem cell growth factor receptor Kit. (274 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (406 aa)
GRM7Metabotropic glutamate receptor 7. (550 aa)
DGKDDiacylglycerol kinase. (1249 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (229 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (402 aa)
GRM4Metabotropic glutamate receptor 4 isoform X1. (914 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
MRASRas-related protein M-Ras. (210 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta-like. (239 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (621 aa)
GRM2Metabotropic glutamate receptor 2 isoform X1. (884 aa)
PLA2G4BPhospholipase A2. (769 aa)
PLA2G4EPhospholipase A2. (823 aa)
DGKZDiacylglycerol kinase. (885 aa)
PLD2Phospholipase. (522 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
TSC1Hamartin isoform X1. (1168 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X4. (892 aa)
DGKHDiacylglycerol kinase. (1202 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (875 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
AGPAT51-acyl-sn-glycerol-3-phosphate acyltransferase epsilon. (466 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
SOS2Son of sevenless homolog 2. (1308 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (165 aa)
PTGFRProstaglandin F2-alpha receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (415 aa)
KRASGTPase KRas isoform X1. (418 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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