STRINGSTRING
MCM3 MCM3 ANAPC11 ANAPC11 CDC6 CDC6 DBF4 DBF4 CCNB2 CCNB2 YWHAQ YWHAQ CDC26 CDC26 GADD45B GADD45B E2F3 E2F3 CCNE2 CCNE2 FZR1 FZR1 PTTG1 PTTG1 ORC1 ORC1 CDKN1B CDKN1B CCND1 CCND1 E2F1 E2F1 LOC112911081 LOC112911081 TGFB1 TGFB1 CDC27 CDC27 ANAPC13 ANAPC13 STAG1 STAG1 PLK1 PLK1 CDKN2C CDKN2C BUB3 BUB3 TGFB3 TGFB3 CCNB1 CCNB1 CDK7 CDK7 HDAC2 HDAC2 EP300 EP300 RBX1 RBX1 MCM6 MCM6 SMC3 SMC3 LOC112908960 LOC112908960 GADD45A GADD45A CDC20 CDC20 PKMYT1 PKMYT1 ANAPC10 ANAPC10 ORC3 ORC3 MDM2 MDM2 SKP2 SKP2 ORC4 ORC4 E2F4 E2F4 SFN SFN TGFB2 TGFB2 YWHAZ YWHAZ CCNA2 CCNA2 ANAPC4 ANAPC4 CDC16 CDC16 TFDP1 TFDP1 SMAD4 SMAD4 ORC5 ORC5 SMAD3 SMAD3 RAD21 RAD21 ATM ATM CDK6 CDK6 HDAC1 HDAC1 CREBBP CREBBP ANAPC7 ANAPC7 PRKDC PRKDC CUL1 CUL1 ANAPC5 ANAPC5 CDK4 CDK4 CCNE1 CCNE1 MYC MYC CDKN2D CDKN2D MCM4 MCM4 CDC23 CDC23 CDC25C CDC25C CCND2 CCND2 CCNB3 CCNB3 MCM2 MCM2 ORC2 ORC2 YWHAB YWHAB TTK TTK RBL2 RBL2 CHEK1 CHEK1 CDC7 CDC7 SKP1 SKP1 YWHAE YWHAE LOC112913400 LOC112913400 CDC14A CDC14A CDK2 CDK2 CCNH CCNH CDC14B CDC14B MCM7 MCM7 MCM5 MCM5 YWHAG YWHAG ATR ATR PCNA PCNA CDC45 CDC45 WEE1 WEE1 CHEK2 CHEK2 TFDP2 TFDP2 CDKN1A CDKN1A BUB1B BUB1B CCNA1 CCNA1 CCND3 CCND3 E2F2 E2F2 BUB1 BUB1 ABL1 ABL1 WEE2 WEE2 TP53 TP53 ESPL1 ESPL1 SMAD2 SMAD2 RB1 RB1 MAD2L2 MAD2L2 SMC1B SMC1B ANAPC1 ANAPC1 STAG2 STAG2 ZBTB17 ZBTB17 YWHAH YWHAH RBL1 RBL1 ANAPC2 ANAPC2 CDC25A CDC25A SMC1A SMC1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM3DNA helicase; Belongs to the MCM family. (825 aa)
ANAPC11Anaphase-promoting complex subunit 11 isoform X1. (84 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (516 aa)
DBF4Activator of S phase kinase. (79 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (397 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (245 aa)
CDC26Anaphase-promoting complex subunit CDC26 isoform X2. (125 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (198 aa)
E2F3Transcription factor E2F3. (224 aa)
CCNE2G1/S-specific cyclin-E2 isoform X2; Belongs to the cyclin family. (404 aa)
FZR1Fizzy-related protein homolog isoform X2. (571 aa)
PTTG1Securin. (207 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (386 aa)
E2F1Transcription factor E2F1. (390 aa)
LOC112911081Mitotic spindle assembly checkpoint protein MAD2A. (190 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CDC27Cell division cycle protein 27 homolog isoform X1. (825 aa)
ANAPC13Anaphase-promoting complex subunit 13. (74 aa)
STAG1Cohesin subunit SA-1. (1258 aa)
PLK1Serine/threonine-protein kinase PLK. (607 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
BUB3Mitotic checkpoint protein BUB3 isoform X2. (330 aa)
TGFB3Transforming growth factor beta-3. (412 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (348 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (516 aa)
EP300Histone acetyltransferase p300 isoform X1. (2430 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
LOC112908960Cohesin subunit SA-2-like isoform X1. (744 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (151 aa)
CDC20Cell division cycle protein 20 homolog. (525 aa)
PKMYT1Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase. (530 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (196 aa)
ORC3Origin recognition complex subunit 3 isoform X1. (772 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (177 aa)
SKP2S-phase kinase-associated protein 2. (436 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
E2F4Transcription factor E2F4. (412 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
YWHAZ14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (255 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (431 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
CDC16Cell division cycle protein 16 homolog isoform X1. (620 aa)
TFDP1Transcription factor. (410 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RAD21Double-strand-break repair protein rad21 homolog. (631 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3060 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (463 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (489 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
ANAPC7Anaphase-promoting complex subunit 7 isoform X1. (598 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X2; Belongs to the PI3/PI4-kinase family. (4136 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
ANAPC5Anaphase-promoting complex subunit 5. (755 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (395 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (524 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
MCM4DNA helicase; Belongs to the MCM family. (865 aa)
CDC23Cell division cycle protein 23 homolog isoform X1. (597 aa)
CDC25CLOW QUALITY PROTEIN: M-phase inducer phosphatase 3. (476 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (325 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1334 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
ORC2Origin recognition complex subunit 2. (574 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
TTKDual specificity protein kinase TTK. (879 aa)
RBL2Retinoblastoma-like protein 2 isoform X1. (1139 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
CDC7Cell division cycle 7-related protein kinase. (576 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
YWHAE14-3-3 protein epsilon isoform X3; Belongs to the 14-3-3 family. (244 aa)
LOC112913400Protein DBF4 homolog A. (629 aa)
CDC14ADual specificity protein phosphatase CDC14A isoform X2. (611 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CCNHLOW QUALITY PROTEIN: cyclin-H; Belongs to the cyclin family. (322 aa)
CDC14BDual specificity protein phosphatase CDC14B isoform X5. (461 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (653 aa)
MCM5DNA helicase; Belongs to the MCM family. (763 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
ATRSerine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2637 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CDC45Cell division control protein 45 homolog. (569 aa)
WEE1Wee1-like protein kinase isoform X1. (627 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
TFDP2Transcription factor. (430 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1158 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (401 aa)
E2F2Transcription factor E2F2. (447 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1. (1084 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
WEE2Wee1-like protein kinase. (566 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ESPL1Separin. (2103 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RB1Retinoblastoma-associated protein. (928 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
SMC1BStructural maintenance of chromosomes protein. (1235 aa)
ANAPC1Anaphase-promoting complex subunit 1. (1943 aa)
STAG2Cohesin subunit SA-2 isoform X1. (1299 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17 isoform X1. (797 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (269 aa)
RBL1Retinoblastoma-like protein 1 isoform X1. (1068 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (836 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (524 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.