STRINGSTRING
RRAGA RRAGA EIF2S1 EIF2S1 SQSTM1 SQSTM1 VAMP8 VAMP8 CTSB CTSB PRKAA1 PRKAA1 BNIP3 BNIP3 CTSD CTSD PIK3R4 PIK3R4 INS INS MTMR3 MTMR3 ULK1 ULK1 ZFYVE1 ZFYVE1 ATG5 ATG5 PIK3CA PIK3CA GABARAPL1 GABARAPL1 LOC112925668 LOC112925668 AKT2 AKT2 WIPI2 WIPI2 ERN1 ERN1 PIK3R1 PIK3R1 PRKCQ PRKCQ ENSVVUP00000009109 ENSVVUP00000009109 TRAF6 TRAF6 IGBP1 IGBP1 LOC112914774 LOC112914774 RHEB RHEB WIPI1 WIPI1 RUBCN RUBCN MAP2K2 MAP2K2 BCL2L1 BCL2L1 ATG9B ATG9B NRBF2 NRBF2 PDPK1 PDPK1 MLST8 MLST8 HMGB1 HMGB1 NRAS NRAS ATG4A ATG4A RRAGD RRAGD RPS6KB2 RPS6KB2 IRS4 IRS4 LOC112912558 LOC112912558 RAB39B RAB39B ITPR1-2 ITPR1-2 MAPK10 MAPK10 RAB7B RAB7B DAPK2 DAPK2 LAMP1 LAMP1 MAP3K7 MAP3K7 IGF1R IGF1R TBK1 TBK1 RAF1 RAF1 RRAGB RRAGB ATG7 ATG7 DEPTOR DEPTOR ATG4C ATG4C CAMKK2 CAMKK2 HRAS HRAS ATG4D ATG4D BCL2 BCL2 RB1CC1 RB1CC1 VMP1 VMP1 RPS6KB1 RPS6KB1 RAB7A RAB7A RPTOR RPTOR TANK TANK CFLAR CFLAR RAB8A-2 RAB8A-2 STX17 STX17 ATG12 ATG12 PPP2CB PPP2CB MAPK1 MAPK1 AKT1S1 AKT1S1 MAPK8 MAPK8 C9orf72 C9orf72 SNAP29 SNAP29 PPP2CA PPP2CA RAB33B RAB33B ATG3 ATG3 CTSL CTSL DAPK1 DAPK1 RRAS RRAS DDIT4 DDIT4 ATG4B ATG4B LOC112908732 LOC112908732 STK11 STK11 RRAGC RRAGC ATG10 ATG10 PRKCD PRKCD BECN1 BECN1 RRAS2 RRAS2 GABARAPL2 GABARAPL2 UVRAG UVRAG ATG16L2 ATG16L2 MTMR14 MTMR14 WDR41 WDR41 ATG16L1 ATG16L1 ATG9A ATG9A IRS1 IRS1 MAPK3 MAPK3 EIF2AK4 EIF2AK4 AKT3 AKT3 PIK3CB PIK3CB MRAS MRAS PRKAA2 PRKAA2 PRKACA PRKACA MAPK9 MAPK9 AMBRA1 AMBRA1 ATG2A ATG2A RAB1A RAB1A PIK3C3 PIK3C3 ATG101 ATG101 GABARAP GABARAP ATG2B ATG2B MTOR MTOR TSC1 TSC1 EIF2AK3 EIF2AK3 HIF1A HIF1A ATG14 ATG14 BAD BAD ULK2 ULK2 PRKACB PRKACB SMCR8 SMCR8 SH3GLB1 SH3GLB1 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RRAGARas-related GTP-binding protein A. (345 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
SQSTM1Sequestosome-1. (444 aa)
VAMP8Vesicle-associated membrane protein 8. (101 aa)
CTSBCathepsin B isoform X1; Belongs to the peptidase C1 family. (339 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (293 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (410 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MTMR3Myotubularin-related protein 3 isoform X1. (1203 aa)
ULK1Serine/threonine-protein kinase ULK1. (995 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1. (787 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (133 aa)
LOC112925668High mobility group protein B1-like. (207 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
WIPI2WD repeat domain phosphoinositide-interacting protein 2 isoform X2. (442 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (991 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (463 aa)
ENSVVUP00000009109Cathepsin L1-like. (105 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
IGBP1Immunoglobulin-binding protein 1. (343 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
RHEBGTP-binding protein Rheb. (168 aa)
WIPI1WD repeat domain phosphoinositide-interacting protein 1. (457 aa)
RUBCNRun domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X5. (1138 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (398 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (918 aa)
NRBF2Nuclear receptor-binding factor 2 isoform X1. (288 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
HMGB1High mobility group protein B1. (215 aa)
NRASGTPase NRas. (189 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (372 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (589 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1173 aa)
LOC112912558Cathepsin L1; Belongs to the peptidase C1 family. (333 aa)
RAB39BRas-related protein Rab-39B. (213 aa)
ITPR1-2Inositol 1,4,5-trisphosphate receptor type 1. (1018 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
RAB7BRas-related protein Rab-7b isoform X1. (200 aa)
DAPK2Death-associated protein kinase 2; Belongs to the protein kinase superfamily. (387 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (420 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IGF1RTyrosine-protein kinase receptor. (1249 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (820 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
RRAGBRas-related GTP-binding protein B isoform X1. (404 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (752 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (409 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (458 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (583 aa)
HRASGTPase HRas isoform X1. (189 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (472 aa)
BCL2Apoptosis regulator Bcl-2. (125 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
VMP1Vacuole membrane protein 1 isoform X2. (406 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1536 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (475 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (509 aa)
RAB8A-2Ras-related protein Rab-8A. (210 aa)
STX17Syntaxin-17; Belongs to the syntaxin family. (302 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (310 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
C9orf72Guanine nucleotide exchange C9orf72 homolog. (481 aa)
SNAP29Synaptosomal-associated protein 29. (258 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
RAB33BRas-related protein Rab-33B. (225 aa)
ATG3Autophagy-related protein 3. (314 aa)
CTSLLOW QUALITY PROTEIN: cathepsin L1. (100 aa)
DAPK1Death-associated protein kinase 1. (1430 aa)
RRASRas-related protein R-Ras. (218 aa)
DDIT4DNA damage-inducible transcript 4 protein. (230 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (371 aa)
LOC112908732Cathepsin L1-like; Belongs to the peptidase C1 family. (335 aa)
STK11Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (517 aa)
RRAGCRas-related GTP-binding protein C. (362 aa)
ATG10Ubiquitin-like-conjugating enzyme ATG10 isoform X1. (220 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
BECN1Beclin-1 isoform X1. (471 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (177 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (254 aa)
UVRAGUV radiation resistance-associated gene protein. (699 aa)
ATG16L2Autophagy-related protein 16-2 isoform X2. (340 aa)
MTMR14Myotubularin-related protein 14 isoform X1. (648 aa)
WDR41WD repeat-containing protein 41 isoform X1. (518 aa)
ATG16L1Autophagy-related protein 16-1 isoform X2. (749 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (778 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
EIF2AK4eIF-2-alpha kinase GCN2 isoform X1. (1654 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MRASRas-related protein M-Ras. (210 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1302 aa)
ATG2AAutophagy-related protein 2 homolog A. (1965 aa)
RAB1ARas-related protein Rab-1A. (205 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
ATG101Autophagy-related protein 101. (218 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (233 aa)
ATG2BAutophagy-related protein 2 homolog B. (2031 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
TSC1Hamartin isoform X1. (1168 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1113 aa)
HIF1AHypoxia-inducible factor 1-alpha. (764 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (573 aa)
BADBcl2-associated agonist of cell death. (157 aa)
ULK2Serine/threonine-protein kinase ULK2. (1135 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
SMCR8Guanine nucleotide exchange protein SMCR8. (935 aa)
SH3GLB1endophilin-B1 isoform X1. (401 aa)
KRASGTPase KRas isoform X1. (418 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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