STRINGSTRING
LMAN2 LMAN2 YOD1 YOD1 EIF2S1 EIF2S1 PDIA6 PDIA6 CANX CANX PRKN-2 PRKN-2 RNF185 RNF185 CAPN2 CAPN2 EDEM2 EDEM2 UBE2J2 UBE2J2 TXNDC5 TXNDC5 MOGS MOGS SEC63 SEC63 STT3B STT3B SSR1 SSR1 SSR2 SSR2 UBQLN4 UBQLN4 SEC61A2 SEC61A2 ERN1 ERN1 DNAJC3 DNAJC3 UBXN4 UBXN4 UGGT2 UGGT2 RBX1 RBX1 ERLEC1 ERLEC1 HSPBP1 HSPBP1 TUSC3 TUSC3 WFS1 WFS1 UBQLN1 UBQLN1 NSFL1C NSFL1C TRAM1L1 TRAM1L1 SEC24D SEC24D UBE2D1 UBE2D1 UGGT1 UGGT1 BAG2 BAG2 UBXN6 UBXN6 EDEM3 EDEM3 EDEM1 EDEM1 SEC61G SEC61G ATF6 ATF6 UBE2D2 UBE2D2 HSPA5 HSPA5 UBE2J1 UBE2J1 MAN1A2 MAN1A2 PDIA3 PDIA3 DNAJC1 DNAJC1 HSPA4L HSPA4L MAN1C1 MAN1C1 STUB1 STUB1 NFE2L2 NFE2L2 SEC23B SEC23B MBTPS2 MBTPS2 ERP29 ERP29 MAPK10 MAPK10 CASP12 CASP12 RRBP1 RRBP1 SEL1L2 SEL1L2 ATF4 ATF4 SELENOS SELENOS UBXN2A UBXN2A DNAJC5 DNAJC5 EIF2AK1 EIF2AK1 MAN1A1 MAN1A1 UBQLN2 UBQLN2 UBQLN3 UBQLN3 DNAJA2 DNAJA2 CRYAB CRYAB LMAN1 LMAN1 DERL1 DERL1 PREB PREB CUL1 CUL1 PDIA4 PDIA4 DNAJC10 DNAJC10 OS9 OS9 CRYAA CRYAA SEC24B SEC24B HSP90B1 HSP90B1 BCL2 BCL2 MARCHF6 MARCHF6 DDIT3 DDIT3 HSPH1 HSPH1 RPN1 RPN1 SEC61A1 SEC61A1 DNAJC5B DNAJC5B EIF2AK2 EIF2AK2 TRAM1 TRAM1 LOC112932473 LOC112932473 SEC61B SEC61B DAD1 DAD1 SSR3 SSR3 P4HB P4HB SIL1 SIL1 STT3A STT3A HSPA8 HSPA8 SEL1L SEL1L MAPK8 MAPK8 SEC23A SEC23A SEC24A SEC24A BAG1 BAG1 DNAJA1 DNAJA1 PLAA PLAA SAR1B SAR1B SKP1 SKP1 SAR1A SAR1A AMFR AMFR LOC112913617 LOC112913617 DNAJB12 DNAJB12 BAX BAX PPP1R15A PPP1R15A CKAP4 CKAP4 SEC24C SEC24C HERPUD1 HERPUD1 SEC13 SEC13 PRKCSH PRKCSH UBE2G2 UBE2G2 HYOU1 HYOU1 CALR CALR SEC31A SEC31A SEC31B SEC31B UFD1 UFD1 BAK1 BAK1 DNAJB2 DNAJB2 XBP1 XBP1 TRAF2 TRAF2 EIF2AK4 EIF2AK4 VCP VCP MAPK9 MAPK9 DNAJB1 DNAJB1 UBE2G1 UBE2G1 DERL2 DERL2 CAPN1 CAPN1 RAD23B RAD23B SYVN1 SYVN1 HSPA2 HSPA2 NGLY1 NGLY1 FBXO2 FBXO2 FBXO6 FBXO6 EIF2AK3 EIF2AK3 HSP90AA1 HSP90AA1 HSP90AB1 HSP90AB1 RPN2 RPN2 MAN1B1 MAN1B1 DDOST DDOST SSR4 SSR4 BCAP31 BCAP31 ERO1A ERO1A UBXN1 UBXN1 GANAB GANAB MBTPS1 MBTPS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LMAN2Vesicular integral-membrane protein VIP36 isoform X1. (356 aa)
YOD1Ubiquitin thioesterase OTU1. (433 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
PDIA6Protein disulfide-isomerase A6; Belongs to the protein disulfide isomerase family. (432 aa)
CANXCalnexin. (593 aa)
PRKN-2E3 ubiquitin-protein ligase parkin. (176 aa)
RNF185E3 ubiquitin-protein ligase RNF185. (187 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (700 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
UBE2J2Ubiquitin-conjugating enzyme E2 J2. (259 aa)
TXNDC5Thioredoxin domain-containing protein 5; Belongs to the protein disulfide isomerase family. (353 aa)
MOGSMannosyl-oligosaccharide glucosidase. (836 aa)
SEC63Translocation protein SEC63 homolog. (738 aa)
STT3BDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B. (825 aa)
SSR1Translocon-associated protein subunit alpha isoform X1. (298 aa)
SSR2Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (183 aa)
UBQLN4Ubiquilin-4. (573 aa)
SEC61A2Protein transport protein SEC61 subunit alpha. (234 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (991 aa)
DNAJC3dnaJ homolog subfamily C member 3. (504 aa)
UBXN4UBX domain-containing protein 4 isoform X1. (507 aa)
UGGT2UDP-glucose:glycoprotein glucosyltransferase 2. (1512 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
ERLEC1Endoplasmic reticulum lectin 1 isoform X2. (483 aa)
HSPBP1Hsp70-binding protein 1. (357 aa)
TUSC3Tumor suppressor candidate 3 isoform X2. (439 aa)
WFS1Wolframin isoform X2. (999 aa)
UBQLN1Ubiquilin-1 isoform X1. (585 aa)
NSFL1CNSFL1 cofactor p47. (348 aa)
TRAM1L1Translocating chain-associated membrane protein; Belongs to the TRAM family. (370 aa)
SEC24DProtein transport protein Sec24D isoform X1. (1034 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
UGGT1UDP-glucose:glycoprotein glucosyltransferase 1. (1533 aa)
BAG2BAG family molecular chaperone regulator 2. (211 aa)
UBXN6UBX domain-containing protein 6. (471 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (933 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (545 aa)
SEC61GProtein transport protein Sec61 subunit gamma. (66 aa)
ATF6Cyclic AMP-dependent transcription factor ATF-6 alpha. (658 aa)
UBE2D2Ubiquitin-conjugating enzyme E2 D2 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Belongs to the heat shock protein 70 family. (654 aa)
UBE2J1Ubiquitin-conjugating enzyme E2 J1. (303 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
DNAJC1dnaJ homolog subfamily C member 1. (587 aa)
HSPA4LHeat shock 70 kDa protein 4L. (966 aa)
MAN1C1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (631 aa)
STUB1E3 ubiquitin-protein ligase CHIP. (303 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (626 aa)
SEC23BProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (742 aa)
MBTPS2Membrane-bound transcription factor site-2 protease isoform X1. (528 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
CASP12Caspase-12; Belongs to the peptidase C14A family. (404 aa)
RRBP1Ribosome-binding protein 1. (1406 aa)
SEL1L2Protein sel-1 homolog 2. (694 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (373 aa)
SELENOSSelenoprotein S. (188 aa)
UBXN2AUBX domain-containing protein 2A. (258 aa)
DNAJC5dnaJ homolog subfamily C member 5. (214 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1. (630 aa)
MAN1A1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (648 aa)
UBQLN2Ubiquilin-2. (623 aa)
UBQLN3Ubiquilin-3. (655 aa)
DNAJA2dnaJ homolog subfamily A member 2. (412 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
LMAN1Protein ERGIC-53 isoform X1. (518 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (372 aa)
PREBProlactin regulatory element-binding protein isoform X1. (418 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PDIA4Protein disulfide-isomerase A4. (635 aa)
DNAJC10DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (796 aa)
OS9Protein OS-9 isoform X2. (667 aa)
CRYAAAlpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (173 aa)
SEC24BLOW QUALITY PROTEIN: protein transport protein Sec24B. (1250 aa)
HSP90B1Endoplasmin. (804 aa)
BCL2Apoptosis regulator Bcl-2. (125 aa)
MARCHF6E3 ubiquitin-protein ligase MARCH6. (922 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
HSPH1Heat shock protein 105 kDa isoform X1. (859 aa)
RPN1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (607 aa)
SEC61A1Protein transport protein Sec61 subunit alpha isoform X1. (476 aa)
DNAJC5BdnaJ homolog subfamily C member 5B. (246 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (533 aa)
TRAM1Translocating chain-associated membrane protein 1 isoform X1. (398 aa)
LOC112932473dnaJ homolog subfamily B member 11-like. (361 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
DAD1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (115 aa)
SSR3Translocon-associated protein subunit gamma. (229 aa)
P4HBProtein disulfide-isomerase. (527 aa)
SIL1Nucleotide exchange factor SIL1 isoform X2. (464 aa)
STT3ADolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A. (787 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (647 aa)
SEL1LProtein sel-1 homolog 1. (788 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
SEC24AProtein transport protein Sec24A isoform X1. (1139 aa)
BAG1BAG family molecular chaperone regulator 1. (321 aa)
DNAJA1dnaJ homolog subfamily A member 1. (397 aa)
PLAAPhospholipase A-2-activating protein isoform X1. (796 aa)
SAR1BGTP-binding protein SAR1b; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
SAR1AGTP-binding protein SAR1a; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
AMFRE3 ubiquitin-protein ligase AMFR. (608 aa)
LOC112913617Heat shock 70 kDa protein 1; Belongs to the heat shock protein 70 family. (642 aa)
DNAJB12dnaJ homolog subfamily B member 12 isoform X1. (373 aa)
BAXApoptosis regulator BAX isoform X2. (192 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (685 aa)
CKAP4Cytoskeleton-associated protein 4. (527 aa)
SEC24CProtein transport protein Sec24C isoform X1. (1119 aa)
HERPUD1Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein. (393 aa)
SEC13Protein SEC13 homolog; Belongs to the WD repeat SEC13 family. (308 aa)
PRKCSHGlucosidase 2 subunit beta isoform X1. (537 aa)
UBE2G2Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (232 aa)
HYOU1Hypoxia up-regulated protein 1 isoform X4. (1073 aa)
CALRCalreticulin. (417 aa)
SEC31AProtein transport protein Sec31A isoform X2. (1252 aa)
SEC31BProtein transport protein Sec31B isoform X4. (1177 aa)
UFD1Ubiquitin recognition factor in ER-associated degradation protein 1. (398 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X2. (211 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (355 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (227 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (533 aa)
EIF2AK4eIF-2-alpha kinase GCN2 isoform X1. (1654 aa)
VCPTransitional endoplasmic reticulum ATPase isoform X1; Belongs to the AAA ATPase family. (839 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
DNAJB1dnaJ homolog subfamily B member 1. (340 aa)
UBE2G1Ubiquitin-conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (171 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
CAPN1Calpain-1 catalytic subunit isoform X1; Belongs to the peptidase C2 family. (715 aa)
RAD23BUV excision repair protein RAD23 homolog B. (387 aa)
SYVN1E3 ubiquitin-protein ligase synoviolin isoform X4. (666 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (637 aa)
NGLY1peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1. (774 aa)
FBXO2F-box only protein 2. (387 aa)
FBXO6F-box only protein 6. (367 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1113 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (663 aa)
HSP90AB1LOW QUALITY PROTEIN: heat shock protein HSP 90-beta. (696 aa)
RPN2Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (703 aa)
MAN1B1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (660 aa)
DDOSTDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (647 aa)
SSR4Translocon-associated protein subunit delta isoform X2. (255 aa)
BCAP31B-cell receptor-associated protein 31. (446 aa)
ERO1AERO1-like protein alpha. (507 aa)
UBXN1UBX domain-containing protein 1. (317 aa)
GANABNeutral alpha-glucosidase AB isoform X1; Belongs to the glycosyl hydrolase 31 family. (966 aa)
MBTPS1Membrane-bound transcription factor site-1 protease. (1050 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (12%) [HD]