STRINGSTRING
SGK1 SGK1 IKBKB IKBKB RRAGA RRAGA ATP6V1D ATP6V1D FZD8 FZD8 RPS6 RPS6 LPIN1 LPIN1 WNT10A WNT10A WNT6 WNT6 ATP6V1C2 ATP6V1C2 BRAF BRAF PRKAA1 PRKAA1 RICTOR RICTOR INS INS SLC7A5 SLC7A5 FZD3 FZD3 CASTOR1 CASTOR1 ATP6V1G1 ATP6V1G1 TBC1D7 TBC1D7 ULK1 ULK1 DVL1 DVL1 PIK3CA PIK3CA LRP6 LRP6 WNT9B WNT9B WNT3 WNT3 ATP6V1E2 ATP6V1E2 PRKCB PRKCB LAMTOR2 LAMTOR2 STRADA STRADA AKT2 AKT2 PIK3R1 PIK3R1 PRKCA PRKCA LOC112914774 LOC112914774 RHEB RHEB LAMTOR3 LAMTOR3 MAP2K2 MAP2K2 PRKCG PRKCG LPIN2 LPIN2 PDPK1 PDPK1 MLST8 MLST8 NRAS NRAS LRP5 LRP5 GRB10 GRB10 MAPKAP1 MAPKAP1 RRAGD RRAGD RPS6KB2 RPS6KB2 WNT2 WNT2 ATP6V1F ATP6V1F SKP2 SKP2 TELO2 TELO2 RPS6KA6 RPS6KA6 GRB2 GRB2 FZD5 FZD5 RPS6KA1 RPS6KA1 TNFRSF1A TNFRSF1A SESN2 SESN2 RPS6KA3 RPS6KA3 ATP6V1G1-2 ATP6V1G1-2 NPRL3 NPRL3 SEH1L SEH1L LOC112916519 LOC112916519 FZD1 FZD1 IGF1R IGF1R WNT8A WNT8A CASTOR2 CASTOR2 RAF1 RAF1 RRAGB RRAGB MIOS MIOS DEPTOR DEPTOR WNT2B WNT2B ATP6V1C1 ATP6V1C1 FZD6 FZD6 HRAS HRAS WNT16 WNT16 RNF152 RNF152 CLIP1 CLIP1 ATP6V1H ATP6V1H IGF1 IGF1 FZD2 FZD2 RPS6KB1 RPS6KB1 WNT7A WNT7A FZD7 FZD7 RPTOR RPTOR FZD4 FZD4 SOS1 SOS1 STRADB STRADB WNT10B WNT10B WNT1 WNT1 EIF4EBP1 EIF4EBP1 MAPK1 MAPK1 ATP6V1G2 ATP6V1G2 TNF TNF AKT1S1 AKT1S1 WNT5A WNT5A FNIP2 FNIP2 SLC38A9 SLC38A9 RPS6KA2 RPS6KA2 ATP6V1A ATP6V1A ATP6V1E1 ATP6V1E1 DDIT4 DDIT4 STK11 STK11 RRAGC RRAGC LAMTOR4 LAMTOR4 SEC13 SEC13 WDR59 WDR59 WNT11 WNT11 FZD9 FZD9 CHUK CHUK WNT7B WNT7B WNT8B WNT8B LAMTOR1 LAMTOR1 EIF4E2 EIF4E2 CAB39 CAB39 FZD10 FZD10 IRS1 IRS1 MAPK3 MAPK3 ATP6V1B2 ATP6V1B2 AKT3 AKT3 PIK3CB PIK3CB PRKAA2 PRKAA2 LAMTOR5-2 LAMTOR5-2 DVL2 DVL2 EIF4B-2 EIF4B-2 ATP6V1B1 ATP6V1B1 CAB39L CAB39L INSR INSR MTOR MTOR NPRL2 NPRL2 TSC1 TSC1 PRR5 PRR5 FNIP1 FNIP1 RHOA RHOA LPIN3 LPIN3 DEPDC5 DEPDC5 TTI1 TTI1 ATP6V1G3 ATP6V1G3 SOS2 SOS2 SLC3A2 SLC3A2 ULK2 ULK2 FLCN FLCN WNT4 WNT4 KRAS KRAS WNT3A WNT3A WNT9A WNT9A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SGK1Non-specific serine/threonine protein kinase. (526 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (782 aa)
RRAGARas-related GTP-binding protein A. (345 aa)
ATP6V1DV-type proton ATPase subunit D. (310 aa)
FZD8LOW QUALITY PROTEIN: frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family. (632 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (266 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform X2. (1039 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (427 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (765 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1684 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (563 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1 isoform X1. (329 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (110 aa)
TBC1D7TBC1 domain family member 7 isoform X1. (293 aa)
ULK1Serine/threonine-protein kinase ULK1. (995 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
WNT3Wingless-type MMTV integration site family, member 3. (170 aa)
ATP6V1E2V-type proton ATPase subunit E 2. (226 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
LAMTOR2Ragulator complex protein LAMTOR2. (125 aa)
STRADASTE20-related kinase adapter protein alpha isoform X1. (431 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
RHEBGTP-binding protein Rheb. (168 aa)
LAMTOR3Ragulator complex protein LAMTOR3. (124 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (398 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LPIN2Phosphatidate phosphatase LPIN2. (942 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
NRASGTPase NRas. (189 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1630 aa)
GRB10Growth factor receptor-bound protein 10. (586 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (587 aa)
RRAGDRas-related GTP-binding protein D. (396 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (589 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
SKP2S-phase kinase-associated protein 2. (436 aa)
TELO2Telomere length regulation protein TEL2 homolog. (875 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (359 aa)
SESN2Sestrin-2. (484 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ATP6V1G1-2V-type H+-transporting ATPase subunit G. (108 aa)
NPRL3GATOR complex protein NPRL3 isoform X1. (551 aa)
SEH1LNucleoporin SEH1 isoform X3; Belongs to the WD repeat SEC13 family. (478 aa)
LOC112916519Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (576 aa)
IGF1RTyrosine-protein kinase receptor. (1249 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
CASTOR2Cytosolic arginine sensor for mTORC1 subunit 2. (663 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
RRAGBRas-related GTP-binding protein B isoform X1. (404 aa)
MIOSGATOR complex protein MIOS isoform X1. (875 aa)
DEPTORDEP domain-containing mTOR-interacting protein. (409 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (405 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
HRASGTPase HRas isoform X1. (189 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (287 aa)
RNF152E3 ubiquitin-protein ligase RNF152. (203 aa)
CLIP1CAP-Gly domain-containing linker protein 1 isoform X3. (2183 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (567 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (505 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1536 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
STRADBSTE20-related kinase adapter protein beta. (415 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (96 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (310 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FNIP2Folliculin-interacting protein 2 isoform X1. (1154 aa)
SLC38A9Sodium-coupled neutral amino acid transporter 9 isoform X1. (558 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (618 aa)
ATP6V1E1V-type proton ATPase subunit E 1. (222 aa)
DDIT4DNA damage-inducible transcript 4 protein. (230 aa)
STK11Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (517 aa)
RRAGCRas-related GTP-binding protein C. (362 aa)
LAMTOR4Ragulator complex protein LAMTOR4 isoform X2. (209 aa)
SEC13Protein SEC13 homolog; Belongs to the WD repeat SEC13 family. (308 aa)
WDR59GATOR complex protein WDR59 isoform X1. (989 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (411 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
LAMTOR1Ragulator complex protein LAMTOR1. (161 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (250 aa)
CAB39Calcium-binding protein 39. (373 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
LAMTOR5-2Ragulator complex protein LAMTOR5. (91 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X4. (732 aa)
EIF4B-2Eukaryotic translation initiation factor 4B isoform X1. (364 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
CAB39LCalcium-binding protein 39-like. (337 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
NPRL2GATOR complex protein NPRL2. (393 aa)
TSC1Hamartin isoform X1. (1168 aa)
PRR5Proline-rich protein 5. (401 aa)
FNIP1Folliculin-interacting protein 1 isoform X1. (1168 aa)
RHOATransforming protein RhoA. (193 aa)
LPIN3Phosphatidate phosphatase LPIN3 isoform X1. (847 aa)
DEPDC5GATOR complex protein DEPDC5 isoform X4. (1463 aa)
TTI1TELO2-interacting protein 1 homolog. (1092 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
SOS2Son of sevenless homolog 2. (1308 aa)
SLC3A24F2 cell-surface antigen heavy chain. (533 aa)
ULK2Serine/threonine-protein kinase ULK2. (1135 aa)
FLCNFolliculin. (935 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
KRASGTPase KRas isoform X1. (418 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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