STRINGSTRING
PFKFB2 PFKFB2 PRKAG3 PRKAG3 GYS2 GYS2 PPP2R2C PPP2R2C PRKAA1 PRKAA1 PPP2R2D PPP2R2D INS INS LOC112912812 LOC112912812 ADRA1A ADRA1A PPP2R2A PPP2R2A ULK1 ULK1 PIK3CA PIK3CA CCND1 CCND1 CPT1A CPT1A FOXO3 FOXO3 FASN FASN STRADA STRADA AKT2 AKT2 PPP2R3A PPP2R3A PFKFB1 PFKFB1 EEF2K EEF2K PIK3R1 PIK3R1 ADIPOR1 ADIPOR1 PFKFB3 PFKFB3 CREB3L2 CREB3L2 ACACB ACACB LEP LEP PFKP-2 PFKP-2 LOC112914774 LOC112914774 PRKAB2 PRKAB2 PRKAG2 PRKAG2 RHEB RHEB PPP2R5A PPP2R5A EEF2 EEF2 PPP2R3B PPP2R3B CREB3L3 CREB3L3 PDPK1 PDPK1 LIPE LIPE CFTR CFTR RPS6KB2 RPS6KB2 IRS4 IRS4 PPP2R1A PPP2R1A CREB1 CREB1 ADIPOQ ADIPOQ CCNA2 CCNA2 PPARGC1A PPARGC1A PRKAB1 PRKAB1 MAP3K7 MAP3K7 IGF1R IGF1R TBC1D1 TBC1D1 PPARG PPARG LEPR LEPR PFKM-2 PFKM-2 RAB10 RAB10 CAMKK2 CAMKK2 G6PC2 G6PC2 PCK1 PCK1 G6PC3 G6PC3 IGF1 IGF1 RAB2A RAB2A RPS6KB1 RPS6KB1 RPTOR RPTOR STRADB STRADB HNF4A HNF4A RAB8A-2 RAB8A-2 ACACA ACACA CD36 CD36 PPP2CB PPP2CB PPP2R3C PPP2R3C EIF4EBP1 EIF4EBP1 ADIPOR2 ADIPOR2 AKT1S1 AKT1S1 PRKAG1 PRKAG1 PPP2R2B PPP2R2B CPT1C CPT1C PPP2CA PPP2CA FBP2 FBP2 FBP1 FBP1 STK11 STK11 GYS1 GYS1 G6PC G6PC PFKL PFKL SCD5 SCD5 CREB5 CREB5 SCD SCD HMGCR HMGCR RAB11B RAB11B CAB39 CAB39 CPT1B CPT1B IRS1 IRS1 AKT3 AKT3 PIK3CB PIK3CB PRKAA2 PRKAA2 CCNA1 CCNA1 FOXO1 FOXO1 ELAVL1 ELAVL1 CREB3L1 CREB3L1 PPP2R5B PPP2R5B PPP2R5D PPP2R5D SLC2A4 SLC2A4 CAB39L CAB39L INSR INSR CRTC2 CRTC2 MTOR MTOR TSC1 TSC1 PPP2R5C PPP2R5C PCK2 PCK2 PPP2R5E PPP2R5E PFKFB4 PFKFB4 SREBF1 SREBF1 MLYCD MLYCD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PFKFB26-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X3. (518 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (608 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PPP2R2CProtein phosphatase 2, regulatory subunit B, gamma isoform X1. (405 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (470 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC112912812ELAV-like protein 1. (296 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (466 aa)
ULK1Serine/threonine-protein kinase ULK1. (995 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (386 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
FOXO3Forkhead box protein O3. (453 aa)
FASNFatty acid synthase. (2516 aa)
STRADASTE20-related kinase adapter protein alpha isoform X1. (431 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1152 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1. (467 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1. (649 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
ACACBacetyl-CoA carboxylase 2 isoform X1. (2457 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PFKP-2ATP-dependent 6-phosphofructokinase, platelet type. (100 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X1. (272 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (257 aa)
RHEBGTP-binding protein Rheb. (168 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (493 aa)
EEF2LOW QUALITY PROTEIN: elongation factor 2. (864 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (569 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (525 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
LIPEHormone-sensitive lipase. (755 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1493 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (589 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1173 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ADIPOQAdiponectin. (266 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (431 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (817 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
IGF1RTyrosine-protein kinase receptor. (1249 aa)
TBC1D1TBC1 domain family member 1 isoform X1. (1282 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
LEPRLeptin receptor isoform X1. (1172 aa)
PFKM-2ATP-dependent 6-phosphofructokinase, muscle type. (104 aa)
RAB10Ras-related protein Rab-10. (200 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (583 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
RAB2ARas-related protein Rab-2A isoform X1. (212 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1536 aa)
STRADBSTE20-related kinase adapter protein beta. (415 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X2. (474 aa)
RAB8A-2Ras-related protein Rab-8A. (210 aa)
ACACAacetyl-CoA carboxylase 1 isoform X3. (1142 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
ADIPOR2Adiponectin receptor protein 2. (385 aa)
AKT1S1Proline-rich AKT1 substrate 1 isoform X1. (310 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (365 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (512 aa)
CPT1CCarnitine O-palmitoyltransferase 1, brain isoform; Belongs to the carnitine/choline acetyltransferase family. (785 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FBP2Fructose-1,6-bisphosphatase isozyme 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-1,6-bisphosphatase 1 isoform X1; Belongs to the FBPase class 1 family. (341 aa)
STK11Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (517 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (789 aa)
SCD5stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (254 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (548 aa)
SCDacyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (360 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (933 aa)
RAB11BRas-related protein Rab-11B. (218 aa)
CAB39Calcium-binding protein 39. (373 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
FOXO1Forkhead box protein O1. (670 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (350 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (727 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (604 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (510 aa)
CAB39LCalcium-binding protein 39-like. (337 aa)
INSRTyrosine-protein kinase receptor. (1406 aa)
CRTC2CREB-regulated transcription coactivator 2. (700 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
TSC1Hamartin isoform X1. (1168 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (498 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X1. (500 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X3. (1152 aa)
MLYCDmalonyl-CoA decarboxylase, mitochondrial. (479 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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