STRINGSTRING
ZFP36L2 ZFP36L2 LOC112927180 LOC112927180 VDAC3 VDAC3 BTRC BTRC IL6 IL6 CCNB2 CCNB2 SQSTM1 SQSTM1 LIN9 LIN9 NBN NBN GATA4 GATA4 MAPKAPK2 MAPKAPK2 HIPK2 HIPK2 FBXW11 FBXW11 LOC112912180 LOC112912180 CALM3 CALM3 GADD45B GADD45B E2F3 E2F3 PPP1CB PPP1CB CCNE2 CCNE2 ZFP36L1 ZFP36L1 CAPN2 CAPN2 TRPV4 TRPV4 PIK3CA PIK3CA CCND1 CCND1 E2F1 E2F1 TGFBR2 TGFBR2 FOXO3 FOXO3 LIN52 LIN52 PPP3CC PPP3CC TGFB1 TGFB1 HIPK4 HIPK4 AKT2 AKT2 TGFB3 TGFB3 PIK3R1 PIK3R1 TRAF3IP2 TRAF3IP2 CCNB1 CCNB1 CALML5 CALML5 LOC112914774 LOC112914774 RHEB RHEB HIPK1 HIPK1 SLC25A6 SLC25A6 MAP2K2 MAP2K2 GADD45A GADD45A PPP3CA PPP3CA NFKB1 NFKB1 MAP2K6 MAP2K6 NRAS NRAS MDM2 MDM2 PPP1CA PPP1CA RAD9A RAD9A SLC25A31 SLC25A31 SLC25A5 SLC25A5 MRE11 MRE11 E2F4 E2F4 ITPR1-2 ITPR1-2 NFATC3 NFATC3 TGFB2 TGFB2 SLC25A4 SLC25A4 CCNA2 CCNA2 RASSF5 RASSF5 ENSVVUP00000018614 ENSVVUP00000018614 SMAD3 SMAD3 CALML4 CALML4 CXCL8 CXCL8 HIPK3 HIPK3 LOC112913727 LOC112913727 RAF1 RAF1 ATM ATM CDK6 CDK6 RBBP4 RBBP4 LIN54 LIN54 PPP1CC PPP1CC CDK4 CDK4 CCNE1 CCNE1 MYC MYC HRAS HRAS CCND2 CCND2 CCNB3 CCNB3 TRPM7 TRPM7 NFATC1 NFATC1 MYBL2 MYBL2 PPP3R2 PPP3R2 TGFBR1 TGFBR1 LOC112913586 LOC112913586 RBL2 RBL2 EIF4EBP1 EIF4EBP1 MAPK1 MAPK1 CHEK1 CHEK1 PPID PPID VDAC1 VDAC1 RAD1 RAD1 CDK2 CDK2 RRAS RRAS NFATC2 NFATC2 MCU MCU PPP3CB PPP3CB CACNA1D CACNA1D VDAC2-2 VDAC2-2 SERPINE1 SERPINE1 RRAS2 RRAS2 ATR ATR RAD50 RAD50 MAPK12 MAPK12 MAPK11 MAPK11 CHEK2 CHEK2 MAPK3 MAPK3 MAPK14 MAPK14 MAPK13 MAPK13 CDKN1A CDKN1A AKT3 AKT3 PIK3CB PIK3CB MRAS MRAS CCNA1 CCNA1 CCND3 CCND3 FOXO1 FOXO1 E2F2 E2F2 RELA RELA CAPN1 CAPN1 PPP3R1 PPP3R1 TP53 TP53 SMAD2 SMAD2 RB1 RB1 MTOR MTOR TSC1 TSC1 IL1A IL1A NFATC4 NFATC4 RBL1 RBL1 CDC25A CDC25A MAP2K3 MAP2K3 ITPR2 ITPR2 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFP36L2LOW QUALITY PROTEIN: mRNA decay activator protein ZFP36L2. (601 aa)
LOC112927180Calmodulin-alpha-like. (81 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X2. (283 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (605 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (207 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (397 aa)
SQSTM1Sequestosome-1. (444 aa)
LIN9Protein lin-9 homolog. (490 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (792 aa)
GATA4Transcription factor GATA-4. (236 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (429 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1365 aa)
FBXW11F-box/WD repeat-containing protein 11 isoform X2. (593 aa)
LOC112912180HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1; Belongs to the MHC class I family. (449 aa)
CALM3Calmodulin-1; Belongs to the calmodulin family. (149 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (198 aa)
E2F3Transcription factor E2F3. (224 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (332 aa)
CCNE2G1/S-specific cyclin-E2 isoform X2; Belongs to the cyclin family. (404 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (700 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (386 aa)
E2F1Transcription factor E2F1. (390 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (581 aa)
FOXO3Forkhead box protein O3. (453 aa)
LIN52Protein lin-52 homolog isoform X1. (116 aa)
PPP3CCSerine/threonine-protein phosphatase. (682 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
HIPK4Homeodomain-interacting protein kinase 4. (615 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
TGFB3Transforming growth factor beta-3. (412 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TRAF3IP2Adapter protein CIKS isoform X2. (551 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
RHEBGTP-binding protein Rheb. (168 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X1. (1212 aa)
SLC25A6ADP/ATP translocase 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (439 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (398 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (151 aa)
PPP3CASerine/threonine-protein phosphatase. (572 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (334 aa)
NRASGTPase NRas. (189 aa)
MDM2E3 ubiquitin-protein ligase Mdm2. (177 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (397 aa)
SLC25A31ADP/ATP translocase 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
SLC25A5Solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31. (318 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
E2F4Transcription factor E2F4. (412 aa)
ITPR1-2Inositol 1,4,5-trisphosphate receptor type 1. (1018 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1074 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (330 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (431 aa)
RASSF5Ras association domain-containing protein 5. (396 aa)
ENSVVUP00000018614DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (430 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CALML4Calmodulin-like protein 4. (273 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (137 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X2. (1248 aa)
LOC112913727DLA class I histocompatibility antigen, A9/A9 alpha chain; Belongs to the MHC class I family. (361 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3060 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (463 aa)
RBBP4Histone-binding protein RBBP4 isoform X1. (425 aa)
LIN54Protein lin-54 homolog isoform X2. (767 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (395 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (524 aa)
HRASGTPase HRas isoform X1. (189 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (325 aa)
CCNB3G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1334 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7 isoform X1. (1840 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (1004 aa)
MYBL2Myb-related protein B. (685 aa)
PPP3R2Calcineurin subunit B type 2. (252 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
LOC112913586DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X2; Belongs to the MHC class I family. (318 aa)
RBL2Retinoblastoma-like protein 2 isoform X1. (1139 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
PPIDPeptidyl-prolyl cis-trans isomerase D. (410 aa)
VDAC1Voltage-dependent anion-selective channel protein 1 isoform X1. (283 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
RRASRas-related protein R-Ras. (218 aa)
NFATC2LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2. (902 aa)
MCUCalcium uniporter protein, mitochondrial isoform X1. (337 aa)
PPP3CBSerine/threonine-protein phosphatase. (529 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2167 aa)
VDAC2-2Voltage-dependent anion-selective channel protein 2. (119 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (459 aa)
RRAS2Ras-related protein R-Ras2 isoform X1. (177 aa)
ATRSerine/threonine-protein kinase ATR isoform X2; Belongs to the PI3/PI4-kinase family. (2637 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
MAPK12Mitogen-activated protein kinase. (348 aa)
MAPK11Mitogen-activated protein kinase. (332 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (413 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MRASRas-related protein M-Ras. (210 aa)
CCNA1cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (401 aa)
FOXO1Forkhead box protein O1. (670 aa)
E2F2Transcription factor E2F2. (447 aa)
RELATranscription factor p65 isoform X2. (542 aa)
CAPN1Calpain-1 catalytic subunit isoform X1; Belongs to the peptidase C2 family. (715 aa)
PPP3R1Calcineurin subunit B type 1. (192 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RB1Retinoblastoma-associated protein. (928 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2553 aa)
TSC1Hamartin isoform X1. (1168 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (903 aa)
RBL1Retinoblastoma-like protein 1 isoform X1. (1068 aa)
CDC25AM-phase inducer phosphatase 1 isoform X1. (524 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (397 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
KRASGTPase KRas isoform X1. (418 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (14%) [HD]