STRINGSTRING
TGIF2 TGIF2 BMP5 BMP5 PITX2 PITX2 BAMBI BAMBI LOC112912892 LOC112912892 GDF5 GDF5 ROCK1 ROCK1 ZFYVE9 ZFYVE9 TGFBR2 TGFBR2 LOC112908263 LOC112908263 TGFB1 TGFB1 ACVR2B ACVR2B INHBA INHBA SMURF2 SMURF2 TGFB3 TGFB3 EP300 EP300 RBX1 RBX1 BMPR1B BMPR1B HJV HJV ID1 ID1 ID2 ID2 SMAD1 SMAD1 TGIF1 TGIF1 IFNG IFNG RPS6KB2 RPS6KB2 ACVR2A ACVR2A PPP2R1A PPP2R1A E2F4 E2F4 NOG NOG DCN DCN CHRD CHRD TGFB2 TGFB2 TFDP1 TFDP1 RGMA RGMA SMAD7 SMAD7 SMAD4 SMAD4 SMAD3 SMAD3 FMOD FMOD THSD4 THSD4 FBN1 FBN1 CREBBP CREBBP CUL1 CUL1 MYC MYC BMP7 BMP7 SMAD5 SMAD5 INHBE INHBE INHBC INHBC RPS6KB1 RPS6KB1 BMPR2 BMPR2 NEO1 NEO1 TGFBR1 TGFBR1 PPP2CB PPP2CB MAPK1 MAPK1 ACVR1 ACVR1 ACVR1C ACVR1C TNF TNF PPP2CA PPP2CA SKP1 SKP1 NODAL NODAL BMP2 BMP2 ZFYVE16 ZFYVE16 FST FST MAPK3 MAPK3 GREM1 GREM1 GREM2 GREM2 THBS1 THBS1 SMAD9 SMAD9 ID3 ID3 SP1 SP1 AMHR2 AMHR2 SMAD2 SMAD2 RHOA RHOA RBL1 RBL1 NBL1 NBL1 BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGIF2Homeobox protein TGIF2. (237 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PITX2Homeobox protein. (325 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LOC112912892Hepcidin. (85 aa)
GDF5Growth/differentiation factor 5. (499 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1366 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1423 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (581 aa)
LOC112908263Bone morphogenetic protein 8B-like. (255 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
INHBAInhibin beta A chain. (424 aa)
SMURF2E3 ubiquitin-protein ligase. (779 aa)
TGFB3Transforming growth factor beta-3. (412 aa)
EP300Histone acetyltransferase p300 isoform X1. (2430 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
HJVHemojuvelin isoform X4. (410 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
ID2DNA-binding protein inhibitor ID-2. (196 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TGIF1Homeobox protein TGIF1. (272 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (589 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
E2F4Transcription factor E2F4. (412 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (216 aa)
DCNDecorin; May affect the rate of fibrils formation. (360 aa)
CHRDChordin isoform X2. (883 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TFDP1Transcription factor. (410 aa)
RGMARepulsive guidance molecule A. (514 aa)
SMAD7Mothers against decapentaplegic homolog. (429 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
FMODFibromodulin. (389 aa)
THSD4Thrombospondin type-1 domain-containing protein 4 isoform X1. (658 aa)
FBN1Fibrillin-1. (2881 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (524 aa)
BMP7Bone morphogenetic protein 7. (432 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
INHBEInhibin beta E chain. (324 aa)
INHBCInhibin beta C chain. (351 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1045 aa)
NEO1Neogenin. (1450 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (490 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (610 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (363 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
NODALNodal homolog isoform X1. (348 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1536 aa)
FSTFollistatin isoform X1. (344 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
GREM1Gremlin. (184 aa)
GREM2Gremlin. (168 aa)
THBS1Thrombospondin-1. (1170 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (549 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RHOATransforming protein RhoA. (193 aa)
RBL1Retinoblastoma-like protein 1 isoform X1. (1068 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (338 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (409 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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