STRINGSTRING
ARHGAP35 ARHGAP35 VAV3 VAV3 MYL9 MYL9 LAMA2 LAMA2 ROCK2 ROCK2 ITGB1 ITGB1 BRAF BRAF COL6A3-2 COL6A3-2 SHC1 SHC1 PPP1CB PPP1CB LAMA3 LAMA3 PIP5K1C PIP5K1C ACTN1 ACTN1 THBS3 THBS3 CAPN2 CAPN2 RASGRF1 RASGRF1 ITGA3 ITGA3 ROCK1 ROCK1 MYLK MYLK PIP5K1B PIP5K1B COL1A1 COL1A1 PIK3CA PIK3CA CCND1 CCND1 CHAD CHAD COL9A2 COL9A2 PGF PGF CTNNB1 CTNNB1 ITGB3 ITGB3 PRKCB PRKCB DOCK1 DOCK1 AKT2 AKT2 KDR KDR PAK4 PAK4 PPP1R12B-2 PPP1R12B-2 ITGA9 ITGA9 PIK3R1 PIK3R1 FYN FYN PRKCA PRKCA LAMA4 LAMA4 ACTN4 ACTN4 ITGB5 ITGB5 LOC112914774 LOC112914774 PPP1R12C PPP1R12C PDGFRB PDGFRB ITGA10 ITGA10 COMP COMP ITGB8 ITGB8 PRKCG PRKCG MYL7 MYL7 PAK2 PAK2 ITGAV ITGAV LAMC1 LAMC1 LAMC2 LAMC2 FN1 FN1 PDPK1 PDPK1 SPP1 SPP1 IBSP IBSP MYL12A MYL12A MYL12B MYL12B FLT1 FLT1 COL9A1 COL9A1 LAMB3 LAMB3 VEGFD VEGFD EGFR EGFR PPP1R12A PPP1R12A COL4A6 COL4A6 RAP1B RAP1B PPP1CA PPP1CA FLNC FLNC MET MET COL4A5 COL4A5 CAV1 CAV1 BIRC3 BIRC3 TLN2 TLN2 BIRC2 BIRC2 TNC TNC GRB2 GRB2 LOC112912529 LOC112912529 LAMA1 LAMA1 VEGFC VEGFC PIP5K1A PIP5K1A MYL5 MYL5 MAPK10 MAPK10 PDGFD PDGFD TNR TNR IGF1R IGF1R PDGFB PDGFB RELN RELN ITGB4 ITGB4 PTK2 PTK2 ITGA11 ITGA11 RAF1 RAF1 COL9A3 COL9A3 ITGA6 ITGA6 COL1A2 COL1A2 RAC1 RAC1 PAK5 PAK5 PPP1CC PPP1CC RAP1A RAP1A SHC4 SHC4 VTN VTN ITGA4 ITGA4 VWF VWF HRAS HRAS LAMB4 LAMB4 ELK1 ELK1 EGF EGF BCL2 BCL2 IGF1 IGF1 COL2A1 COL2A1 CCND2 CCND2 SOS1 SOS1 MYLK4 MYLK4 ITGB6 ITGB6 HGF HGF FLNB FLNB VAV1 VAV1 MAPK1 MAPK1 LAMB1 LAMB1 COL4A1 COL4A1 MAPK8 MAPK8 CRKL CRKL CRK CRK MYL2-2 MYL2-2 SHC3 SHC3 TLN1 TLN1 PAK1 PAK1 RAC2 RAC2 ITGA7 ITGA7 COL6A2 COL6A2 BCAR1 BCAR1 ILK ILK PDGFRA PDGFRA THBS4 THBS4 PARVA PARVA CAV3 CAV3 ITGA1 ITGA1 ITGA2 ITGA2 COL4A3 COL4A3 COL4A4 COL4A4 MAPK3 MAPK3 MYLPF MYLPF THBS1 THBS1 PAK6 PAK6 AKT3 AKT3 PIK3CB PIK3CB CCND3 CCND3 FLT4 FLT4 MAPK9 MAPK9 LAMC3 LAMC3 ITGB7 ITGB7 RAPGEF1 RAPGEF1 PARVG PARVG PARVB PARVB XIAP XIAP PDGFA PDGFA RHOA RHOA LAMB2 LAMB2 SRC SRC FLNA FLNA BAD BAD SOS2 SOS2 ARHGAP5 ARHGAP5 CDC42 CDC42
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGAP35Rho GTPase-activating protein 35. (1516 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (867 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
LAMA2Laminin subunit alpha-2. (3017 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1327 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (765 aa)
COL6A3-2Collagen alpha-3(VI) chain isoform X1. (547 aa)
SHC1SHC-transforming protein 1 isoform X1. (583 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (332 aa)
LAMA3Laminin subunit alpha-3. (1680 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1. (696 aa)
ACTN1Alpha-actinin-1. (913 aa)
THBS3Thrombospondin-3. (936 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (700 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1 isoform X1. (1276 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (970 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1366 aa)
MYLKMyosin light chain kinase, smooth muscle isoform X1. (1998 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (575 aa)
COL1A1Collagen alpha-1(I) chain. (1288 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (386 aa)
CHADChondroadherin. (359 aa)
COL9A2LOW QUALITY PROTEIN: collagen alpha-2(IX) chain. (427 aa)
PGFPlacenta growth factor isoform X3; Belongs to the PDGF/VEGF growth factor family. (288 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
DOCK1LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1; Belongs to the DOCK family. (1838 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1355 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
PPP1R12B-2Protein phosphatase 1 regulatory subunit 12B isoform X1. (142 aa)
ITGA9Integrin alpha-9; Belongs to the integrin alpha chain family. (934 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FYNTyrosine-protein kinase. (537 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
LAMA4Laminin subunit alpha-4. (1767 aa)
ACTN4Alpha-actinin-4 isoform X3. (911 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (838 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (773 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1135 aa)
ITGA10Integrin alpha-10 isoform X1; Belongs to the integrin alpha chain family. (1165 aa)
COMPCartilage oligomeric matrix protein. (332 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (782 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MYL7Myosin regulatory light chain 2, atrial isoform. (186 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1054 aa)
LAMC1Laminin subunit gamma-1. (1573 aa)
LAMC2Laminin subunit gamma-2 isoform X1. (1194 aa)
FN1Fibronectin. (2267 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
SPP1Osteopontin isoform X1. (303 aa)
IBSPBone sialoprotein 2. (313 aa)
MYL12AMyosin regulatory light polypeptide 9-like. (172 aa)
MYL12BMyosin regulatory light chain 12B. (180 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1295 aa)
COL9A1Collagen alpha-1(IX) chain. (164 aa)
LAMB3Laminin subunit beta-3 isoform X1. (1172 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
EGFRReceptor protein-tyrosine kinase. (1154 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1045 aa)
COL4A6Collagen alpha-6(IV) chain isoform X1. (1554 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
FLNCfilamin-C isoform X2. (2742 aa)
METHepatocyte growth factor receptor isoform X1. (1282 aa)
COL4A5Collagen alpha-5(IV) chain isoform X2. (1484 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
TLN2Talin-2 isoform X2. (2556 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (459 aa)
TNCTenascin isoform X2. (2380 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
LOC112912529Platelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (127 aa)
LAMA1Laminin subunit alpha-1. (2985 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2. (570 aa)
MYL5Myosin light chain 5. (174 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
PDGFDPlatelet-derived growth factor D isoform X2. (350 aa)
TNRtenascin-R. (1356 aa)
IGF1RTyrosine-protein kinase receptor. (1249 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
RELNLOW QUALITY PROTEIN: reelin. (3224 aa)
ITGB4Integrin beta. (1805 aa)
PTK2Focal adhesion kinase 1 isoform X3; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1059 aa)
ITGA11Integrin alpha-11; Belongs to the integrin alpha chain family. (1123 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
COL9A3Collagen alpha-3(IX) chain isoform X1. (570 aa)
ITGA6Integrin alpha-6 isoform X1; Belongs to the integrin alpha chain family. (1082 aa)
COL1A2Collagen alpha-2(I) chain. (1274 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (202 aa)
PAK5Non-specific serine/threonine protein kinase. (775 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
RAP1ARas-related protein Rap-1A. (336 aa)
SHC4SHC-transforming protein 4. (631 aa)
VTNVitronectin. (464 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (1030 aa)
VWFVon Willebrand factor. (2826 aa)
HRASGTPase HRas isoform X1. (189 aa)
LAMB4Laminin subunit beta-4. (1755 aa)
ELK1ETS domain-containing protein Elk-1. (435 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1211 aa)
BCL2Apoptosis regulator Bcl-2. (125 aa)
IGF1Insulin-like growth factor I isoform X1. (187 aa)
COL2A1Collagen alpha-1(II) chain. (1147 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (325 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (444 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
FLNBfilamin-B isoform X4. (2077 aa)
VAV1Proto-oncogene vav. (846 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
LAMB1Laminin subunit beta-1. (1809 aa)
COL4A1Collagen alpha-1(IV) chain. (1580 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
CRKLCrk-like protein. (303 aa)
CRKAdapter molecule crk isoform X1. (285 aa)
MYL2-2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (158 aa)
SHC3SHC-transforming protein 3. (289 aa)
TLN1Talin-1 isoform X1. (2562 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (173 aa)
ITGA7Integrin alpha-7 isoform X1; Belongs to the integrin alpha chain family. (1181 aa)
COL6A2Collagen alpha-2(VI) chain. (960 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X2. (964 aa)
ILKIntegrin-linked protein kinase. (508 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1111 aa)
THBS4Thrombospondin-4. (944 aa)
PARVAAlpha-parvin. (360 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ITGA1Integrin alpha-1; Belongs to the integrin alpha chain family. (1143 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1155 aa)
COL4A3Collagen alpha-3(IV) chain. (1320 aa)
COL4A4Collagen alpha-4(IV) chain isoform X1. (1688 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform. (200 aa)
THBS1Thrombospondin-1. (1170 aa)
PAK6Non-specific serine/threonine protein kinase. (715 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (401 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
LAMC3Laminin subunit gamma-3. (1475 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (878 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X3. (1240 aa)
PARVGGamma-parvin. (332 aa)
PARVBBeta-parvin. (390 aa)
XIAPE3 ubiquitin-protein ligase XIAP. (493 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (343 aa)
RHOATransforming protein RhoA. (193 aa)
LAMB2Laminin subunit beta-2 isoform X2. (1850 aa)
SRCTyrosine-protein kinase. (536 aa)
FLNAfilamin-A isoform X1. (2646 aa)
BADBcl2-associated agonist of cell death. (157 aa)
SOS2Son of sevenless homolog 2. (1308 aa)
ARHGAP5Rho GTPase-activating protein 5 isoform X1. (1506 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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