STRINGSTRING
MICALL2 MICALL2 MYL9 MYL9 MPP5 MPP5 NEDD4 NEDD4 PRKAG3 PRKAG3 PARD3 PARD3 PRKCI PRKCI CLDN11 CLDN11 PPP2R2C PPP2R2C CGNL1 CGNL1 CD1D CD1D ROCK2 ROCK2 LOC112912075 LOC112912075 ITGB1 ITGB1 LOC112912078 LOC112912078 CLDN19 CLDN19 GATA4 GATA4 PRKAA1 PRKAA1 PPP2R2D PPP2R2D SYMPK SYMPK ACTN1 ACTN1 NF2 NF2 PPP2R2A PPP2R2A BVES BVES TJP2 TJP2 ROCK1 ROCK1 TJP3 TJP3 PRKCZ PRKCZ CCND1 CCND1 YBX3 YBX3 ARHGAP17 ARHGAP17 PRKCE PRKCE ARHGEF2 ARHGEF2 AMOTL2 AMOTL2 CLDN18 CLDN18 ACTR3 ACTR3 LOC112934546 LOC112934546 EZR EZR MARVELD2 MARVELD2 OCLN OCLN DLG3 DLG3 ACTN4 ACTN4 TUBAL3 TUBAL3 SYNPO SYNPO ACTR3B ACTR3B PRKAB2 PRKAB2 PRKAG2 PRKAG2 CLDN20 CLDN20 DLG1 DLG1 CLDN6 CLDN6 CLDN9 CLDN9 MYL12A MYL12A MYL12B MYL12B CLDN2 CLDN2 SLC9A3R1 SLC9A3R1 CFTR CFTR AMOT AMOT PPP2R1A PPP2R1A RAB8B RAB8B LLGL2 LLGL2 AMOTL1 AMOTL1 PARD6A PARD6A CGN CGN CLDN24 CLDN24 PRKAB1 PRKAB1 MAPK10 MAPK10 ENSVVUP00000018278 ENSVVUP00000018278 CLDN1 CLDN1 CLDN16 CLDN16 RAP2C RAP2C MAGI1 MAGI1 RAC1 RAC1 RDX RDX LOC112925884 LOC112925884 F11R F11R CLDN25 CLDN25 RAP1A RAP1A IGSF5 IGSF5 CDK4 CDK4 DLG2-2 DLG2-2 CD1E CD1E CD1B CD1B CD1C CD1C LOC112910124 LOC112910124 PARD6G PARD6G RAB8A-2 RAB8A-2 MYH11 MYH11 JAM3 JAM3 PPP2CB PPP2CB TJP1 TJP1 RUNX1 RUNX1 CLDN14 CLDN14 MYH14 MYH14 CLDN17 CLDN17 CLDN8 CLDN8 TIAM1 TIAM1 PRKAG1 PRKAG1 LOC112921105 LOC112921105 MAPK8 MAPK8 TUBA1C TUBA1C RAPGEF2 RAPGEF2 PPP2R2B PPP2R2B PPP2CA PPP2CA MAP3K1 MAP3K1 MYL2-2 MYL2-2 MYL6 MYL6 MYL6B MYL6B HCLS1 HCLS1 PARD6B PARD6B SCRIB SCRIB MSN MSN MPDZ MPDZ STK11 STK11 TUBA8 TUBA8 CACNA1D CACNA1D MYH9 MYH9 CLDN15 CLDN15 JAM2 JAM2 HSPA4 HSPA4 PCNA PCNA CLDN3 CLDN3 CLDN4 CLDN4 CLDN5 CLDN5 LOC112922521 LOC112922521 TUBA4A TUBA4A PATJ PATJ PRKAA2 PRKAA2 PRKACA PRKACA MAPK9 MAPK9 ACTR2 ACTR2 CLDN7 CLDN7 ARHGEF18 ARHGEF18 MYH10 MYH10 TJAP1 TJAP1 RHOA RHOA RAPGEF6 RAPGEF6 SRC SRC PRKACB PRKACB LLGL1 LLGL1 CDC42 CDC42
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MICALL2MICAL-like protein 2 isoform X1. (894 aa)
MYL9Myosin regulatory light polypeptide 9. (172 aa)
MPP5MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa)
NEDD4E3 ubiquitin-protein ligase. (900 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (608 aa)
PARD3Partitioning defective 3 homolog. (1328 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (571 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
PPP2R2CProtein phosphatase 2, regulatory subunit B, gamma isoform X1. (405 aa)
CGNL1Cingulin-like protein 1 isoform X1. (1295 aa)
CD1DAntigen-presenting glycoprotein CD1d. (293 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1327 aa)
LOC112912075T-cell surface glycoprotein CD1a-like. (357 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
LOC112912078T-cell surface glycoprotein CD1a-like. (326 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (227 aa)
GATA4Transcription factor GATA-4. (236 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (470 aa)
SYMPKSymplekin. (1149 aa)
ACTN1Alpha-actinin-1. (913 aa)
NF2Merlin isoform X1. (596 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (466 aa)
BVESBlood vessel epicardial substance. (371 aa)
TJP2Tight junction protein ZO-2 isoform X4; Belongs to the MAGUK family. (1195 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1366 aa)
TJP3LOW QUALITY PROTEIN: tight junction protein ZO-3; Belongs to the MAGUK family. (869 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. (557 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (386 aa)
YBX3Y-box-binding protein 3. (268 aa)
ARHGAP17Rho GTPase-activating protein 17. (762 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (750 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X3. (1175 aa)
AMOTL2Angiomotin-like protein 2 isoform X1. (777 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
LOC112934546Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (477 aa)
EZREzrin isoform X1. (575 aa)
MARVELD2MARVEL domain-containing protein 2. (554 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (560 aa)
DLG3Disks large homolog 3 isoform X2; Belongs to the MAGUK family. (835 aa)
ACTN4Alpha-actinin-4 isoform X3. (911 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
SYNPOSynaptopodin isoform X1. (925 aa)
ACTR3BActin-related protein 3B isoform X2; Belongs to the actin family. (436 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2 isoform X1. (272 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (257 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
DLG1Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (1043 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (245 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
MYL12AMyosin regulatory light polypeptide 9-like. (172 aa)
MYL12BMyosin regulatory light chain 12B. (180 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (246 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (350 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1493 aa)
AMOTAngiomotin isoform X1. (1080 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
RAB8BRas-related protein Rab-8B. (207 aa)
LLGL2Lethal(2) giant larvae protein homolog 2. (1082 aa)
AMOTL1Angiomotin-like protein 1 isoform X1. (999 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (513 aa)
CGNCingulin. (1193 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
ENSVVUP00000018278Tubulin alpha-3 chain. (90 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
RAP2CRas-related protein Rap-2c. (183 aa)
MAGI1Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5. (1415 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (202 aa)
RDXRadixin isoform X1. (629 aa)
LOC112925884Ras-related protein Rab-13-like. (189 aa)
F11RJunctional adhesion molecule A. (292 aa)
CLDN25Putative claudin-25. (228 aa)
RAP1ARas-related protein Rap-1A. (336 aa)
IGSF5Immunoglobulin superfamily member 5. (370 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
DLG2-2Disks large homolog 2 isoform X1. (103 aa)
CD1ET-cell surface glycoprotein CD1e, membrane-associated-like. (392 aa)
CD1BT-cell surface glycoprotein CD1b-like. (337 aa)
CD1CT-cell surface glycoprotein CD1c-like. (340 aa)
LOC112910124T-cell surface glycoprotein CD1a-like. (342 aa)
PARD6GPartitioning defective 6 homolog gamma. (384 aa)
RAB8A-2Ras-related protein Rab-8A. (210 aa)
MYH11Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
JAM3Junctional adhesion molecule C. (324 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
TJP1Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1790 aa)
RUNX1Runt-related transcription factor 1. (234 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
MYH14Myosin-14 isoform X5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2084 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (256 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1591 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (365 aa)
LOC112921105Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (385 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (495 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X1. (1666 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (512 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1397 aa)
MYL2-2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (158 aa)
MYL6Myosin light polypeptide 6 isoform X2. (209 aa)
MYL6BMyosin light chain 6B. (192 aa)
HCLS1Hematopoietic lineage cell-specific protein. (487 aa)
PARD6BPartitioning defective 6 homolog beta. (364 aa)
SCRIBProtein scribble homolog. (1517 aa)
MSNMoesin. (577 aa)
MPDZMultiple PDZ domain protein isoform X4. (2067 aa)
STK11Serine/threonine-protein kinase STK11 isoform X2; Belongs to the protein kinase superfamily. (517 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2167 aa)
MYH9Myosin-9 isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (233 aa)
JAM2Junctional adhesion molecule B. (301 aa)
HSPA4Heat shock 70 kDa protein 4. (844 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
CLDN4Claudin-4-like. (210 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
LOC112922521Tubulin alpha chain. (416 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (659 aa)
PATJinaD-like protein isoform X1. (1144 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
ARHGEF18Rho guanine nucleotide exchange factor 18. (1117 aa)
MYH10Myosin-10 isoform X7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2035 aa)
TJAP1Tight junction-associated protein 1 isoform X3. (552 aa)
RHOATransforming protein RhoA. (193 aa)
RAPGEF6Rap guanine nucleotide exchange factor 6 isoform X1. (1616 aa)
SRCTyrosine-protein kinase. (536 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
LLGL1Lethal(2) giant larvae protein homolog 1. (1188 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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