STRINGSTRING
VAV3 VAV3 IKBKB IKBKB IL10 IL10 MAP3K8 MAP3K8 ITK ITK PIK3CA PIK3CA PPP3CC PPP3CC FOS FOS AKT2 AKT2 CARD11 CARD11 NCK1 NCK1 PAK4 PAK4 NFKBIB NFKBIB PIK3R1 PIK3R1 FYN FYN PRKCQ PRKCQ GRAP2 GRAP2 LOC112914774 LOC112914774 MAP2K2 MAP2K2 PAK2 PAK2 DLG1 DLG1 PDPK1 PDPK1 PPP3CA PPP3CA NFKB1 NFKB1 NRAS NRAS IFNG IFNG CD4 CD4 GRB2 GRB2 NCK2 NCK2 NFATC3 NFATC3 MAPK10 MAPK10 IL2 IL2 MAP3K7 MAP3K7 RAF1 RAF1 LCK LCK MALT1 MALT1 PAK5 PAK5 CDK4 CDK4 ICOS ICOS CTLA4 CTLA4 CD28 CD28 HRAS HRAS SOS1 SOS1 NFATC1 NFATC1 PPP3R2 PPP3R2 NFKBIA NFKBIA VAV1 VAV1 MAPK1 MAPK1 TNF TNF MAPK8 MAPK8 NFATC2 NFATC2 PPP3CB PPP3CB PAK1 PAK1 TEC TEC LAT LAT CD3G CD3G CD3E CD3E CSF2 CSF2 CHUK CHUK MAPK12 MAPK12 MAPK11 MAPK11 MAPK3 MAPK3 MAPK14 MAPK14 MAPK13 MAPK13 RASGRP1 RASGRP1 PAK6 PAK6 AKT3 AKT3 PIK3CB PIK3CB MAPK9 MAPK9 RELA RELA PPP3R1 PPP3R1 CD8B CD8B CD8A CD8A LOC112915328 LOC112915328 RHOA RHOA PLCG1 PLCG1 NFKBIE NFKBIE IKBKG IKBKG PTPRC PTPRC SOS2 SOS2 BCL10 BCL10 CDC42 CDC42 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (867 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (782 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (179 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
ITKTyrosine-protein kinase. (625 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP3CCSerine/threonine-protein phosphatase. (682 aa)
FOSProto-oncogene c-Fos. (380 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
CARD11Caspase recruitment domain-containing protein 11. (1147 aa)
NCK1Cytoplasmic protein. (377 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FYNTyrosine-protein kinase. (537 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (463 aa)
GRAP2GRB2-related adapter protein 2. (386 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (398 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
DLG1Disks large homolog 1 isoform X3; Belongs to the MAGUK family. (1043 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
PPP3CASerine/threonine-protein phosphatase. (572 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
NRASGTPase NRas. (189 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
CD4T-cell surface glycoprotein CD4. (462 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
NCK2Cytoplasmic protein. (380 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1074 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
LCKTyrosine-protein kinase. (249 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (795 aa)
PAK5Non-specific serine/threonine protein kinase. (775 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
ICOSInducible T-cell costimulator. (208 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
CD28T-cell-specific surface glycoprotein CD28. (217 aa)
HRASGTPase HRas isoform X1. (189 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1 isoform X1. (1004 aa)
PPP3R2Calcineurin subunit B type 2. (252 aa)
NFKBIANF-kappa-B inhibitor alpha. (327 aa)
VAV1Proto-oncogene vav. (846 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
NFATC2LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2. (902 aa)
PPP3CBSerine/threonine-protein phosphatase. (529 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
TECTyrosine-protein kinase. (641 aa)
LATLinker for activation of T-cells family member 1. (238 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (170 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (198 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (147 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
MAPK12Mitogen-activated protein kinase. (348 aa)
MAPK11Mitogen-activated protein kinase. (332 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (413 aa)
RASGRP1LOW QUALITY PROTEIN: RAS guanyl-releasing protein 1. (748 aa)
PAK6Non-specific serine/threonine protein kinase. (715 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
RELATranscription factor p65 isoform X2. (542 aa)
PPP3R1Calcineurin subunit B type 1. (192 aa)
CD8BT-cell surface glycoprotein CD8 beta chain. (418 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain isoform X1. (211 aa)
LOC112915328Tyrosine-protein kinase. (221 aa)
RHOATransforming protein RhoA. (193 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
NFKBIENF-kappa-B inhibitor epsilon. (355 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (419 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X2. (1153 aa)
SOS2Son of sevenless homolog 2. (1308 aa)
BCL10B-cell lymphoma/leukemia 10. (235 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
KRASGTPase KRas isoform X1. (418 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.