STRINGSTRING
ARHGDIA ARHGDIA LOC112927180 LOC112927180 IKBKB IKBKB BRAF BRAF BEX3 BEX3 SHC1 SHC1 RIPK2 RIPK2 ZNF274 ZNF274 MAPKAPK2 MAPKAPK2 SORT1 SORT1 CALM3 CALM3 NGFR NGFR ARHGDIB ARHGDIB PSEN1 PSEN1 PIK3CA PIK3CA FOXO3 FOXO3 LOC112912331 LOC112912331 MAP3K3 MAP3K3 AKT2 AKT2 NFKBIB NFKBIB PIK3R1 PIK3R1 TRAF6 TRAF6 CALML5 CALML5 LOC112914774 LOC112914774 CAMK2A CAMK2A CAMK2D CAMK2D GAB1 GAB1 MAP2K2 MAP2K2 KIDINS220 KIDINS220 PDPK1 PDPK1 NFKB1 NFKB1 NRAS NRAS FRS2 FRS2 RAP1B RAP1B PTPN11 PTPN11 MAGED1 MAGED1 RPS6KA6 RPS6KA6 GRB2 GRB2 IRAK3 IRAK3 RPS6KA1 RPS6KA1 NTRK3 NTRK3 CAMK4 CAMK4 RPS6KA3 RPS6KA3 MAPK10 MAPK10 ATF4 ATF4 FASLG FASLG CALML4 CALML4 RAF1 RAF1 RAC1 RAC1 SH2B3 SH2B3 RAP1A RAP1A SHC4 SHC4 IRAK4 IRAK4 HRAS HRAS NTF3 NTF3 BCL2 BCL2 RPS6KA5 RPS6KA5 SOS1 SOS1 NFKBIA NFKBIA MAPK1 MAPK1 MAPK8 MAPK8 CRKL CRKL MAP3K1 MAP3K1 YWHAE YWHAE CRK CRK RPS6KA2 RPS6KA2 SHC3 SHC3 NTRK2 NTRK2 NTF4 NTF4 BAX BAX CAMK2G CAMK2G PRDM4 PRDM4 PRKCD PRKCD SH2B1 SH2B1 MAPK12 MAPK12 MAPK11 MAPK11 IRS1 IRS1 MAPK3 MAPK3 MAPK14 MAPK14 MAPK13 MAPK13 AKT3 AKT3 PIK3CB PIK3CB MAPK9 MAPK9 RELA RELA TP73 TP73 ABL1 ABL1 TP53 TP53 RAPGEF1 RAPGEF1 RHOA RHOA PLCG1 PLCG1 NFKBIE NFKBIE IRAK1 IRAK1 BAD BAD SOS2 SOS2 MAPK7 MAPK7 CDC42 CDC42 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARHGDIARho GDP-dissociation inhibitor 1. (229 aa)
LOC112927180Calmodulin-alpha-like. (81 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (782 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (765 aa)
BEX3Protein BEX3. (112 aa)
SHC1SHC-transforming protein 1 isoform X1. (583 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
ZNF274Neurotrophin receptor-interacting factor homolog. (187 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (429 aa)
SORT1Sortilin. (764 aa)
CALM3Calmodulin-1; Belongs to the calmodulin family. (149 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (423 aa)
ARHGDIBRho GDP-dissociation inhibitor 2. (200 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOXO3Forkhead box protein O3. (453 aa)
LOC112912331Phosphoinositide phospholipase C. (690 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (616 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
NFKBIBNF-kappa-B inhibitor beta. (357 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CALML5Calmodulin-like protein 5. (149 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2; Belongs to the protein kinase superfamily. (478 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X6. (533 aa)
GAB1GRB2-associated-binding protein 1. (720 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (398 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa isoform X5. (1782 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (601 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
NRASGTPase NRas. (189 aa)
FRS2Fibroblast growth factor receptor substrate 2 isoform X1. (508 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
MAGED1Melanoma-associated antigen D1 isoform X2. (821 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
IRAK3Interleukin-1 receptor-associated kinase 3. (597 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NTRK3NT-3 growth factor receptor isoform X1. (596 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV; Belongs to the protein kinase superfamily. (521 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (373 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (288 aa)
CALML4Calmodulin-like protein 4. (273 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (202 aa)
SH2B3SH2B adapter protein 3. (355 aa)
RAP1ARas-related protein Rap-1A. (336 aa)
SHC4SHC-transforming protein 4. (631 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (477 aa)
HRASGTPase HRas isoform X1. (189 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (352 aa)
BCL2Apoptosis regulator Bcl-2. (125 aa)
RPS6KA5Ribosomal protein S6 kinase. (913 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
NFKBIANF-kappa-B inhibitor alpha. (327 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
CRKLCrk-like protein. (303 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1397 aa)
YWHAE14-3-3 protein epsilon isoform X3; Belongs to the 14-3-3 family. (244 aa)
CRKAdapter molecule crk isoform X1. (285 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
SHC3SHC-transforming protein 3. (289 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
BAXApoptosis regulator BAX isoform X2. (192 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (611 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (801 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
SH2B1SH2B adapter protein 1 isoform X1. (760 aa)
MAPK12Mitogen-activated protein kinase. (348 aa)
MAPK11Mitogen-activated protein kinase. (332 aa)
IRS1Insulin receptor substrate 1. (1239 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (413 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
RELATranscription factor p65 isoform X2. (542 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (698 aa)
ABL1Tyrosine-protein kinase. (1150 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X3. (1240 aa)
RHOATransforming protein RhoA. (193 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
NFKBIENF-kappa-B inhibitor epsilon. (355 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (551 aa)
BADBcl2-associated agonist of cell death. (157 aa)
SOS2Son of sevenless homolog 2. (1308 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
KRASGTPase KRas isoform X1. (418 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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