STRINGSTRING
GNB5 GNB5 LOC112927180 LOC112927180 PPP2R2C PPP2R2C PPP1R1B PPP1R1B GNAQ GNAQ DRD1 DRD1 PPP2R2D PPP2R2D GNAI3 GNAI3 GNG8 GNG8 CALM3 CALM3 GNG7 GNG7 PPP1CB PPP1CB GNGT2 GNGT2 PPP2R2A PPP2R2A ADCY5 ADCY5 GRIN2B GRIN2B KIF5B KIF5B GNB1 GNB1 GNB4 GNB4 PPP3CC PPP3CC GRIA1 GRIA1 PRKCB PRKCB FOS FOS AKT2 AKT2 PPP2R3A PPP2R3A CLOCK CLOCK PRKCA PRKCA CALML5 CALML5 CREB3L2 CREB3L2 CAMK2A CAMK2A PPP2R5A PPP2R5A CAMK2D CAMK2D PPP2R3B PPP2R3B CREB3L3 CREB3L3 GNG12 GNG12 PRKCG PRKCG PPP3CA PPP3CA GNG4 GNG4 GSK3A GSK3A DDC DDC PPP1CA PPP1CA SLC18A2 SLC18A2 PPP2R1A PPP2R1A KIF5C KIF5C GNB3 GNB3 GNG13 GNG13 LOC112929992 LOC112929992 MAOB MAOB CREB1 CREB1 ITPR1-2 ITPR1-2 ATF2 ATF2 MAPK10 MAPK10 GNAL GNAL GRIA4 GRIA4 ATF4 ATF4 CALML4 CALML4 DRD5 DRD5 GNGT1 GNGT1 DRD2 DRD2 PPP1CC PPP1CC KCNJ9 KCNJ9 LOC112932168 LOC112932168 LOC112932169 LOC112932169 SCN1A SCN1A KIF5A KIF5A GRIN2A GRIN2A GNAI1 GNAI1 PPP2CB PPP2CB PPP2R3C PPP2R3C KCNJ3 KCNJ3 MAPK8 MAPK8 GRIA2 GRIA2 PPP2R2B PPP2R2B PPP2CA PPP2CA GNAO1 GNAO1 DRD3 DRD3 SLC6A3 SLC6A3 PLCB4 PLCB4 PPP3CB PPP3CB CACNA1D CACNA1D CAMK2G CAMK2G PLCB1 PLCB1 GNB2 GNB2 GNG14 GNG14 ARRB1 ARRB1 CREB5 CREB5 KCNJ6 KCNJ6 COMT COMT MAPK12 MAPK12 MAPK11 MAPK11 SLC18A1 SLC18A1 MAPK14 MAPK14 MAPK13 MAPK13 AKT3 AKT3 PLCB2 PLCB2 CACNA1A-2 CACNA1A-2 PRKACA PRKACA MAPK9 MAPK9 CREB3L1 CREB3L1 ARRB2 ARRB2 PPP2R5B PPP2R5B PPP2R5D PPP2R5D GRIA3 GRIA3 CACNA1B CACNA1B GNAI2 GNAI2 PPP2R5C PPP2R5C PPP2R5E PPP2R5E GNG2 GNG2 PLCB3 PLCB3 GNG3 GNG3 PRKACB PRKACB ITPR2 ITPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNB5Guanine nucleotide-binding protein subunit beta-5. (342 aa)
LOC112927180Calmodulin-alpha-like. (81 aa)
PPP2R2CProtein phosphatase 2, regulatory subunit B, gamma isoform X1. (405 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B. (166 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (359 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (470 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CALM3Calmodulin-1; Belongs to the calmodulin family. (149 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (332 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (466 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1200 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1513 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
PPP3CCSerine/threonine-protein phosphatase. (682 aa)
GRIA1Glutamate receptor 1. (899 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
FOSProto-oncogene c-Fos. (380 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1152 aa)
CLOCKCircadian locomoter output cycles protein kaput isoform X1. (847 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (678 aa)
CALML5Calmodulin-like protein 5. (149 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2; Belongs to the protein kinase superfamily. (478 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (493 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X6. (533 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1. (569 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (525 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PPP3CASerine/threonine-protein phosphatase. (572 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (105 aa)
GSK3AGlycogen synthase kinase-3 alpha. (446 aa)
DDCaromatic-L-amino-acid decarboxylase. (509 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
SLC18A2Synaptic vesicular amine transporter isoform X1. (532 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (626 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1. (340 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (270 aa)
LOC112929992Amine oxidase. (1018 aa)
MAOBAmine oxidase. (504 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ITPR1-2Inositol 1,4,5-trisphosphate receptor type 1. (1018 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
MAPK10Mitogen-activated protein kinase. (529 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha isoform X1. (380 aa)
GRIA4Glutamate receptor 4 isoform X3. (884 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (373 aa)
CALML4Calmodulin-like protein 4. (273 aa)
DRD5D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (464 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (354 aa)
LOC112932168Guanine nucleotide-binding protein G(S) subunit alpha isoform X6. (394 aa)
LOC112932169Neuroendocrine secretory protein 55. (247 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1850 aa)
KIF5AKinesin heavy chain isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1040 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1457 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X2. (377 aa)
PPP2CBSerine/threonine-protein phosphatase. (279 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (501 aa)
MAPK8Mitogen-activated protein kinase. (387 aa)
GRIA2Glutamate receptor 2 isoform X1. (883 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (512 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (301 aa)
DRD3D(3) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (447 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PPP3CBSerine/threonine-protein phosphatase. (529 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2167 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (611 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (372 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ARRB1Beta-arrestin-1 isoform X2. (422 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (548 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (423 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (269 aa)
MAPK12Mitogen-activated protein kinase. (348 aa)
MAPK11Mitogen-activated protein kinase. (332 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (523 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (413 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1177 aa)
CACNA1A-2Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (296 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (343 aa)
MAPK9Mitogen-activated protein kinase. (382 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (727 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (604 aa)
GRIA3Glutamate receptor 3 isoform X2. (894 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2243 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1. (355 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (543 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (498 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (103 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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