STRINGSTRING
CUL2 CUL2 BRAF BRAF SLC2A1 SLC2A1 PIK3CA PIK3CA ARNT2 ARNT2 TGFB1 TGFB1 EPAS1 EPAS1 EGLN2 EGLN2 AKT2 AKT2 PRCC PRCC PAK4 PAK4 TGFB3 TGFB3 PIK3R1 PIK3R1 EP300 EP300 RBX1 RBX1 EGLN1 EGLN1 LOC112914774 LOC112914774 GAB1 GAB1 MAP2K2 MAP2K2 PAK2 PAK2 NRAS NRAS RAP1B RAP1B PTPN11 PTPN11 MET MET GRB2 GRB2 ARNT ARNT TGFB2 TGFB2 PDGFB PDGFB RAF1 RAF1 RAC1 RAC1 PAK5 PAK5 CREBBP CREBBP RAP1A RAP1A HRAS HRAS ARAF ARAF TFE3 TFE3 SOS1 SOS1 ELOC ELOC HGF HGF MAPK1 MAPK1 CRKL CRKL CRK CRK VHL VHL PAK1 PAK1 MAPK3 MAPK3 CDKN1A CDKN1A FH FH PAK6 PAK6 AKT3 AKT3 PIK3CB PIK3CB RAPGEF1 RAPGEF1 HIF1A HIF1A BAD BAD SOS2 SOS2 EGLN3 EGLN3 FLCN FLCN CDC42 CDC42 KRAS KRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUL2Cullin-2; Belongs to the cullin family. (746 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (765 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (496 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2 isoform X1. (821 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
EPAS1Endothelial PAS domain-containing protein 1. (926 aa)
EGLN2Egl nine homolog 2 isoform X1. (405 aa)
AKT2RAC-beta serine/threonine-protein kinase. (557 aa)
PRCCProline-rich protein PRCC. (489 aa)
PAK4Non-specific serine/threonine protein kinase. (592 aa)
TGFB3Transforming growth factor beta-3. (412 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
EP300Histone acetyltransferase p300 isoform X1. (2430 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
EGLN1Egl nine homolog 1. (128 aa)
LOC112914774Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
GAB1GRB2-associated-binding protein 1. (720 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (398 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
NRASGTPase NRas. (189 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
METHepatocyte growth factor receptor isoform X1. (1282 aa)
GRB2Growth factor receptor-bound protein 2. (351 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (668 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (202 aa)
PAK5Non-specific serine/threonine protein kinase. (775 aa)
CREBBPCREB-binding protein isoform X1. (2442 aa)
RAP1ARas-related protein Rap-1A. (336 aa)
HRASGTPase HRas isoform X1. (189 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (625 aa)
TFE3Transcription factor E3 isoform X1. (571 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
ELOCelongin-C; Belongs to the SKP1 family. (112 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
MAPK1Mitogen-activated protein kinase. (392 aa)
CRKLCrk-like protein. (303 aa)
CRKAdapter molecule crk isoform X1. (285 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (219 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
FHFumarate hydratase, mitochondrial. (508 aa)
PAK6Non-specific serine/threonine protein kinase. (715 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X3. (1240 aa)
HIF1AHypoxia-inducible factor 1-alpha. (764 aa)
BADBcl2-associated agonist of cell death. (157 aa)
SOS2Son of sevenless homolog 2. (1308 aa)
EGLN3Egl nine homolog 3. (119 aa)
FLCNFolliculin. (935 aa)
CDC42Cell division control protein 42 homolog isoform X2. (191 aa)
KRASGTPase KRas isoform X1. (418 aa)
Your Current Organism:
Vulpes vulpes
NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox
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