(44 nodes) Viral myocarditis network (Vulpes vulpes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	LAMA2	Laminin subunit alpha-2. (3017 aa)
	LOC112912664	SLA class II histocompatibility antigen, DQ haplotype C beta chain-like. (313 aa)
	LOC112912663	HLA class II histocompatibility antigen, DQ alpha 2 chain-like; Belongs to the MHC class II family. (255 aa)
	LOC112912180	HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X1; Belongs to the MHC class I family. (449 aa)
	SGCA	Alpha-sarcoglycan. (387 aa)
	SGCD	Delta-sarcoglycan. (292 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (386 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	DMD	Dystrophin isoform X2. (2215 aa)
	SGCG	Gamma-sarcoglycan isoform X1. (309 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	LAMA1	Laminin subunit alpha-1. (2985 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1 isoform X2. (1610 aa)
	ABL2	Tyrosine-protein kinase. (1160 aa)
	CASP3	Caspase-3 isoform X1; Belongs to the peptidase C14A family. (355 aa)
	ENSVVUP00000018614	DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (430 aa)
	LOC112913727	DLA class I histocompatibility antigen, A9/A9 alpha chain; Belongs to the MHC class I family. (361 aa)
	RAC1	Ras-related C3 botulinum toxin substrate 1. (202 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5 isoform X1. (278 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (217 aa)
	LOC112913586	DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X2; Belongs to the MHC class I family. (318 aa)
	PRF1	Perforin-1. (555 aa)
	CD80	T-lymphocyte activation antigen CD80. (235 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (290 aa)
	CD86	T-lymphocyte activation antigen CD86 isoform X1. (343 aa)
	RAC2	Ras-related C3 botulinum toxin substrate 2. (173 aa)
	CXADR	Coxsackievirus and adenovirus receptor isoform X1. (365 aa)
	ITGB2	Integrin beta. (743 aa)
	MYH6	Myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
	SGCB	Beta-sarcoglycan. (438 aa)
	HLA-DRA	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (265 aa)
	LOC112913648	DLA class II histocompatibility antigen, DR-1 beta chain. (287 aa)
	LOC112913861	SLA class II histocompatibility antigen, DQ haplotype C beta chain-like. (269 aa)
	LOC112913867	HLA class II histocompatibility antigen, DM beta chain. (263 aa)
	HLA-DMA	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (265 aa)
	HLA-DOA	HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (220 aa)
	EIF4G2	Eukaryotic translation initiation factor 4 gamma 2. (907 aa)
	CD55	Complement decay-accelerating factor. (693 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	CASP9	Caspase-9 isoform X1; Belongs to the peptidase C14A family. (495 aa)
	ICAM1	Intercellular adhesion molecule 1 isoform X1. (531 aa)
	DAG1	Dystroglycan. (892 aa)
	EIF4G3	Eukaryotic translation initiation factor 4 gamma 3 isoform X6. (1745 aa)

Your Current Organism:

Vulpes vulpes

NCBI taxonomy Id: 9627
Other names: Canis vulpes, V. vulpes, red fox, silver fox

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSVVUP00000038805	ENSVVUP00000017090	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.937
ABL1	CCND1	ENSVVUP00000038805	ENSVVUP00000006071	Tyrosine-protein kinase.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.411
ABL1	RAC1	ENSVVUP00000038805	ENSVVUP00000021128	Tyrosine-protein kinase.	Ras-related C3 botulinum toxin substrate 1.	0.938
ABL1	RAC2	ENSVVUP00000038805	ENSVVUP00000032717	Tyrosine-protein kinase.	Ras-related C3 botulinum toxin substrate 2.	0.938
ABL2	ABL1	ENSVVUP00000017090	ENSVVUP00000038805	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.937
ABL2	RAC1	ENSVVUP00000017090	ENSVVUP00000021128	Tyrosine-protein kinase.	Ras-related C3 botulinum toxin substrate 1.	0.951
ABL2	RAC2	ENSVVUP00000017090	ENSVVUP00000032717	Tyrosine-protein kinase.	Ras-related C3 botulinum toxin substrate 2.	0.938
BID	CASP3	ENSVVUP00000030758	ENSVVUP00000017721	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.638
BID	CASP9	ENSVVUP00000030758	ENSVVUP00000040619	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.608
BID	CYCS	ENSVVUP00000030758	ENSVVUP00000000702	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.603
CASP3	BID	ENSVVUP00000017721	ENSVVUP00000030758	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.638
CASP3	CASP9	ENSVVUP00000017721	ENSVVUP00000040619	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.985
CASP3	CAV1	ENSVVUP00000017721	ENSVVUP00000014366	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.440
CASP3	CCND1	ENSVVUP00000017721	ENSVVUP00000006071	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.747
CASP3	CYCS	ENSVVUP00000017721	ENSVVUP00000000702	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.987
CASP3	ICAM1	ENSVVUP00000017721	ENSVVUP00000040667	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	Intercellular adhesion molecule 1 isoform X1.	0.513
CASP9	BID	ENSVVUP00000040619	ENSVVUP00000030758	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.608
CASP9	CASP3	ENSVVUP00000040619	ENSVVUP00000017721	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.985
CASP9	CCND1	ENSVVUP00000040619	ENSVVUP00000006071	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.720
CASP9	CYCS	ENSVVUP00000040619	ENSVVUP00000000702	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999