STRINGSTRING
GDF2 GDF2 ZFYVE9 ZFYVE9 ENSUAMP00000000756 ENSUAMP00000000756 ENSUAMP00000001661 ENSUAMP00000001661 ACVR1 ACVR1 WWP1 WWP1 ACVR2B ACVR2B INHBA INHBA ACVR2A ACVR2A BMP10 BMP10 SMURF2 SMURF2 ACVRL1 ACVRL1 ACVR1B ACVR1B SMAD4 SMAD4 GDF11 GDF11 SKIL SKIL BMP2 BMP2 BAMBI BAMBI SMAD5 SMAD5 ACVR1C ACVR1C ENSUAMP00000023083 ENSUAMP00000023083 SKI SKI ENSUAMP00000024123 ENSUAMP00000024123 INHBC INHBC INHBE INHBE FSTL3 FSTL3 SMAD3 SMAD3 SMAD6 SMAD6 SMAD2 SMAD2 ITCH ITCH SMAD7 SMAD7 BMP4 BMP4 FST FST INHA INHA MSTN MSTN SMAD9 SMAD9 BMPR1B BMPR1B ZFYVE16 ZFYVE16 BMPR1A BMPR1A BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF2Growth differentiation factor 2. (429 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1422 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
ENSUAMP00000001661TGF_BETA_2 domain-containing protein. (194 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
WWP1E3 ubiquitin-protein ligase. (922 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
INHBAInhibin subunit beta A. (424 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SMURF2E3 ubiquitin-protein ligase. (736 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF11Growth differentiation factor 11. (409 aa)
SKILSKI like proto-oncogene. (684 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
ENSUAMP00000023083Uncharacterized protein. (485 aa)
SKISKI proto-oncogene. (704 aa)
ENSUAMP00000024123Uncharacterized protein. (522 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (351 aa)
FSTL3Follistatin like 3. (267 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD6Mothers against decapentaplegic homolog. (484 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ITCHE3 ubiquitin-protein ligase. (740 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FSTFollistatin. (344 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
MSTNMyostatin. (376 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1497 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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