(31 nodes) Ubiquitin-dependent degradation of Cyclin D network (Ursus americanus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	PSMB2	Proteasome subunit beta. (167 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (400 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (683 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (418 aa)
	ENSUAMP00000003372	Uncharacterized protein. (157 aa)
	ENSUAMP00000004531	AAA domain-containing protein; Belongs to the AAA ATPase family. (421 aa)
	USP14	Ubiquitin specific peptidase 14; Belongs to the peptidase C19 family. (350 aa)
	PSMC3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
	PSMB6	Proteasome subunit beta. (219 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMD7	Proteasome 26S subunit, non-ATPase 7. (322 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (376 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (351 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (536 aa)
	ENSUAMP00000022022	Uncharacterized protein. (107 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	ENSUAMP00000026056	MitMem_reg domain-containing protein. (95 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	PSMA7	Proteasome endopeptidase complex. (248 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4. (344 aa)
	ENSUAMP00000036637	PCI domain-containing protein. (405 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	ENSUAMP00000037175	MPN domain-containing protein. (156 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000003372	ENSUAMP00000004531	ENSUAMP00000003372	ENSUAMP00000004531	Uncharacterized protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.947
ENSUAMP00000003372	ENSUAMP00000022022	ENSUAMP00000003372	ENSUAMP00000022022	Uncharacterized protein.	Uncharacterized protein.	0.993
ENSUAMP00000003372	ENSUAMP00000026056	ENSUAMP00000003372	ENSUAMP00000026056	Uncharacterized protein.	MitMem_reg domain-containing protein.	0.984
ENSUAMP00000003372	ENSUAMP00000036637	ENSUAMP00000003372	ENSUAMP00000036637	Uncharacterized protein.	PCI domain-containing protein.	0.971
ENSUAMP00000003372	ENSUAMP00000037175	ENSUAMP00000003372	ENSUAMP00000037175	Uncharacterized protein.	MPN domain-containing protein.	0.984
ENSUAMP00000003372	PSMA1	ENSUAMP00000003372	ENSUAMP00000025485	Uncharacterized protein.	Proteasome subunit alpha type.	0.996
ENSUAMP00000003372	PSMA3	ENSUAMP00000003372	ENSUAMP00000009230	Uncharacterized protein.	Proteasome subunit alpha type.	0.997
ENSUAMP00000003372	PSMA4	ENSUAMP00000003372	ENSUAMP00000022810	Uncharacterized protein.	Proteasome subunit alpha type.	0.999
ENSUAMP00000003372	PSMA6	ENSUAMP00000003372	ENSUAMP00000030570	Uncharacterized protein.	Proteasome subunit alpha type.	0.999
ENSUAMP00000003372	PSMA7	ENSUAMP00000003372	ENSUAMP00000033181	Uncharacterized protein.	Proteasome endopeptidase complex.	0.998
ENSUAMP00000003372	PSMB2	ENSUAMP00000003372	ENSUAMP00000001276	Uncharacterized protein.	Proteasome subunit beta.	0.995
ENSUAMP00000003372	PSMB4	ENSUAMP00000003372	ENSUAMP00000024914	Uncharacterized protein.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.995
ENSUAMP00000003372	PSMB5	ENSUAMP00000003372	ENSUAMP00000010398	Uncharacterized protein.	Proteasome subunit beta.	0.992
ENSUAMP00000003372	PSMB6	ENSUAMP00000003372	ENSUAMP00000006133	Uncharacterized protein.	Proteasome subunit beta.	0.995
ENSUAMP00000003372	PSMB7	ENSUAMP00000003372	ENSUAMP00000033554	Uncharacterized protein.	Proteasome subunit beta.	0.994
ENSUAMP00000003372	PSMC2	ENSUAMP00000003372	ENSUAMP00000025089	Uncharacterized protein.	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.	0.993
ENSUAMP00000003372	PSMC3	ENSUAMP00000003372	ENSUAMP00000006030	Uncharacterized protein.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.989
ENSUAMP00000003372	PSMC4	ENSUAMP00000003372	ENSUAMP00000001890	Uncharacterized protein.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.969
ENSUAMP00000003372	PSMC5	ENSUAMP00000003372	ENSUAMP00000008848	Uncharacterized protein.	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.	0.972
ENSUAMP00000003372	PSMC6	ENSUAMP00000003372	ENSUAMP00000030034	Uncharacterized protein.	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family.	0.981