STRINGSTRING
IL18R1 IL18R1 LY86 LY86 IL18RAP IL18RAP ENSUAMP00000000518 ENSUAMP00000000518 NOD1 NOD1 BAK1 BAK1 ENSUAMP00000000740 ENSUAMP00000000740 IL1R1 IL1R1 IL1RL2 IL1RL2 TRAF1 TRAF1 TRAF2 TRAF2 IL33 IL33 TAB2 TAB2 ENSUAMP00000002943 ENSUAMP00000002943 XIAP XIAP ENSUAMP00000004351 ENSUAMP00000004351 PRKCQ PRKCQ TAB1 TAB1 ENSUAMP00000005304 ENSUAMP00000005304 ENSUAMP00000005459 ENSUAMP00000005459 NFKB2 NFKB2 MYD88 MYD88 TIRAP TIRAP ENSUAMP00000006824 ENSUAMP00000006824 ENSUAMP00000007992 ENSUAMP00000007992 CASP10 CASP10 CASP8 CASP8 ENSUAMP00000008648 ENSUAMP00000008648 ENSUAMP00000008748 ENSUAMP00000008748 PRKCD PRKCD ENSUAMP00000009272 ENSUAMP00000009272 ENSUAMP00000009537 ENSUAMP00000009537 ENSUAMP00000009578 ENSUAMP00000009578 BOK BOK PYCARD PYCARD ENSUAMP00000010380 ENSUAMP00000010380 NFKBIZ NFKBIZ ENSUAMP00000010575 ENSUAMP00000010575 ENSUAMP00000011161 ENSUAMP00000011161 ENSUAMP00000011223 ENSUAMP00000011223 BNIP3 BNIP3 CARD9 CARD9 BCL2 BCL2 ENSUAMP00000011984 ENSUAMP00000011984 ENSUAMP00000012080 ENSUAMP00000012080 NLRP3 NLRP3 BAX BAX BID BID NFKBIB NFKBIB ENSUAMP00000013825 ENSUAMP00000013825 CARD8 CARD8 RNASE1 RNASE1 IKBKG IKBKG ENSUAMP00000014578 ENSUAMP00000014578 ANG ANG TNF TNF GSDMD GSDMD ENSUAMP00000016311 ENSUAMP00000016311 ENSUAMP00000018082 ENSUAMP00000018082 ENSUAMP00000018294 ENSUAMP00000018294 SATB1 SATB1 TBK1 TBK1 BIRC2 BIRC2 BIRC3 BIRC3 OPTN OPTN MCL1 MCL1 TICAM1 TICAM1 PELI3 PELI3 BAD BAD TLR6 TLR6 TLR1 TLR1 TLR3 TLR3 RIPK1 RIPK1 TRADD TRADD NLRP12 NLRP12 IKBKB IKBKB CASP3 CASP3 NFKBIE NFKBIE NFKB1 NFKB1 TLR2 TLR2 ENSUAMP00000022495 ENSUAMP00000022495 CASP9 CASP9 ENSUAMP00000022738 ENSUAMP00000022738 BCL3 BCL3 RIPK2 RIPK2 TNFSF10 TNFSF10 IL18 IL18 ENSUAMP00000024093 ENSUAMP00000024093 BCL10 BCL10 IRAK1 IRAK1 APAF1 APAF1 NLRP1 NLRP1 IL1F10 IL1F10 IL1RN IL1RN IL36G IL36G ENSUAMP00000025386 ENSUAMP00000025386 ENSUAMP00000025387 ENSUAMP00000025387 ENSUAMP00000025678 ENSUAMP00000025678 ENSUAMP00000025828 ENSUAMP00000025828 ENSUAMP00000025829 ENSUAMP00000025829 PELI1 PELI1 CD180 CD180 CARD10 CARD10 ENSUAMP00000026449 ENSUAMP00000026449 RELA RELA ENSUAMP00000026919 ENSUAMP00000026919 TNFAIP3 TNFAIP3 TAB3 TAB3 IRF5 IRF5 FADD FADD CD28 CD28 TLR5 TLR5 HTRA2 HTRA2 PIDD1 PIDD1 CYCS CYCS TNFRSF1A TNFRSF1A PLEKHG6 PLEKHG6 IKBKE IKBKE BCL2L11 BCL2L11 ENSUAMP00000030146 ENSUAMP00000030146 TRAF6 TRAF6 CYLD CYLD TNIP1 TNIP1 RELB RELB NFKBIA NFKBIA BCL2L1 BCL2L1 MAP3K14 MAP3K14 BMF BMF ENSUAMP00000031438 ENSUAMP00000031438 UNC93B1 UNC93B1 CARD11 CARD11 MAP3K7 MAP3K7 BCL2L2 BCL2L2 RIPK3 RIPK3 CASP6 CASP6 IRAK2 IRAK2 BCL2A1 BCL2A1 ENSUAMP00000032511 ENSUAMP00000032511 CARD6 CARD6 TLR4 TLR4 IL1B IL1B IL1A IL1A DPP9 DPP9 ENSUAMP00000033323 ENSUAMP00000033323 TNFRSF1B TNFRSF1B IRAK3 IRAK3 TRAF3 TRAF3 ENSUAMP00000035027 ENSUAMP00000035027 IRAK4 IRAK4 TLR7 TLR7 TLR8 TLR8 ENSUAMP00000035755 ENSUAMP00000035755 IL18BP IL18BP PMAIP1 PMAIP1 CARD14 CARD14 RNH1 RNH1 CHUK CHUK TANK TANK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL18R1Interleukin 18 receptor 1. (541 aa)
LY86Lymphocyte antigen 86. (158 aa)
IL18RAPInterleukin 18 receptor accessory protein. (573 aa)
ENSUAMP00000000518Uncharacterized protein. (334 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (874 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
ENSUAMP00000000740Uncharacterized protein. (212 aa)
IL1R1Interleukin 1 receptor type 1. (584 aa)
IL1RL2Interleukin 1 receptor like 2. (554 aa)
TRAF1TNF receptor-associated factor. (415 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
IL33Interleukin 33. (263 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (683 aa)
ENSUAMP00000002943RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (169 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
ENSUAMP00000004351CARD domain-containing protein. (165 aa)
PRKCQProtein kinase C theta. (526 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ENSUAMP00000005304Uncharacterized protein. (197 aa)
ENSUAMP00000005459Uncharacterized protein. (783 aa)
NFKB2Nuclear factor kappa B subunit 2. (581 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TIRAPTIR domain containing adaptor protein. (224 aa)
ENSUAMP00000006824Uncharacterized protein. (88 aa)
ENSUAMP00000007992Uncharacterized protein. (219 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
ENSUAMP00000008648Uncharacterized protein. (113 aa)
ENSUAMP00000008748Uncharacterized protein. (510 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
ENSUAMP00000009272Uncharacterized protein. (146 aa)
ENSUAMP00000009537Mitogen-activated protein kinase kinase kinase 8. (174 aa)
ENSUAMP00000009578RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (169 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
PYCARDPYD and CARD domain containing. (194 aa)
ENSUAMP00000010380Uncharacterized protein. (311 aa)
NFKBIZNFKB inhibitor zeta. (721 aa)
ENSUAMP00000010575Uncharacterized protein. (237 aa)
ENSUAMP00000011161Mitogen-activated protein kinase kinase kinase 8. (139 aa)
ENSUAMP00000011223Uncharacterized protein. (224 aa)
BNIP3BCL2 interacting protein 3. (263 aa)
CARD9Caspase recruitment domain family member 9. (566 aa)
BCL2BCL2 apoptosis regulator. (205 aa)
ENSUAMP00000011984Uncharacterized protein. (333 aa)
ENSUAMP00000012080Uncharacterized protein; Belongs to the peptidase C14A family. (409 aa)
NLRP3NLR family pyrin domain containing 3. (922 aa)
BAXBCL2 associated X, apoptosis regulator. (205 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (196 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
ENSUAMP00000013825RHD domain-containing protein. (119 aa)
CARD8Caspase recruitment domain family member 8. (444 aa)
RNASE1Ribonuclease A family member 1, pancreatic; Belongs to the pancreatic ribonuclease family. (152 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (442 aa)
ENSUAMP00000014578Uncharacterized protein. (217 aa)
ANGAngiogenin; Belongs to the pancreatic ribonuclease family. (146 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
GSDMDGasdermin D. (500 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
ENSUAMP00000018294DUF4203 domain-containing protein. (350 aa)
SATB1DNA-binding protein SATB. (777 aa)
TBK1TANK binding kinase 1. (709 aa)
BIRC2Baculoviral IAP repeat containing 2. (619 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
OPTNOptineurin. (573 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (350 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
BADBCL2 associated agonist of cell death. (168 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (778 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (802 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
NLRP12NLR family pyrin domain containing 12. (1054 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (787 aa)
ENSUAMP00000022495Uncharacterized protein. (189 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (467 aa)
ENSUAMP00000022738Uncharacterized protein. (126 aa)
BCL3BCL3 transcription coactivator. (424 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (289 aa)
IL18Interleukin 18. (167 aa)
ENSUAMP00000024093G protein gamma domain-containing protein. (201 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (664 aa)
APAF1Apoptotic peptidase activating factor 1. (948 aa)
NLRP1NLR family pyrin domain containing 1. (1427 aa)
IL1F10Interleukin-1. (152 aa)
IL1RNInterleukin-1. (176 aa)
IL36GInterleukin-1. (163 aa)
ENSUAMP00000025386Interleukin-1. (160 aa)
ENSUAMP00000025387Uncharacterized protein. (222 aa)
ENSUAMP00000025678Uncharacterized protein. (163 aa)
ENSUAMP00000025828Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
ENSUAMP00000025829CARD domain-containing protein. (86 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
CD180CD180 molecule. (632 aa)
CARD10Caspase recruitment domain family member 10. (1087 aa)
ENSUAMP00000026449Uncharacterized protein. (121 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ENSUAMP00000026919TIR domain-containing protein. (1033 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
IRF5Interferon regulatory factor 5. (503 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
CD28CD28 molecule. (216 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (883 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
PIDD1P53-induced death domain protein 1. (911 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
PLEKHG6Pleckstrin homology and RhoGEF domain containing G6. (786 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
BCL2L11BCL2 like 11. (140 aa)
ENSUAMP00000030146Uncharacterized protein. (668 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
TNIP1TNFAIP3 interacting protein 1. (635 aa)
RELBRELB proto-oncogene, NF-kB subunit. (575 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
BCL2L1BCL2 like 1. (233 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
BMFBcl2 modifying factor. (184 aa)
ENSUAMP00000031438Protein kinase domain-containing protein. (456 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (610 aa)
CARD11Caspase recruitment domain family member 11. (1123 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
BCL2L2BCL2 like 2. (193 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (451 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
BCL2A1BCL2 related protein A1. (174 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
CARD6Caspase recruitment domain family member 6. (1023 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (244 aa)
DPP9Dipeptidyl peptidase 9; Belongs to the peptidase S9B family. (891 aa)
ENSUAMP00000033323CARD domain-containing protein. (221 aa)
TNFRSF1BTNF receptor superfamily member 1B. (460 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (577 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
ENSUAMP00000035027Uncharacterized protein. (146 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (477 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
ENSUAMP00000035755Protein kinase domain-containing protein. (105 aa)
IL18BPInterleukin 18 binding protein. (188 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
CARD14Caspase recruitment domain family member 14. (1007 aa)
RNH1Ribonuclease/angiogenin inhibitor 1. (474 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TANKTRAF family member associated NFKB activator. (426 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (12%) [HD]