(7 nodes) CASP8 activity is inhibited, and BIRC2/BIRC3, UBA domain network (Ursus americanus)

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Your Input:
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (395 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (619 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (550 aa)
	TRADD	TNFRSF1A associated via death domain. (314 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (451 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC2	CASP8	ENSUAMP00000018421	ENSUAMP00000007996	Baculoviral IAP repeat containing 2.	Caspase 8; Belongs to the peptidase C14A family.	0.493
BIRC2	FADD	ENSUAMP00000018421	ENSUAMP00000027565	Baculoviral IAP repeat containing 2.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.959
BIRC2	RIPK1	ENSUAMP00000018421	ENSUAMP00000019468	Baculoviral IAP repeat containing 2.	Receptor interacting serine/threonine kinase 1.	0.980
BIRC2	RIPK3	ENSUAMP00000018421	ENSUAMP00000032010	Baculoviral IAP repeat containing 2.	Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily.	0.956
BIRC2	TRADD	ENSUAMP00000018421	ENSUAMP00000019860	Baculoviral IAP repeat containing 2.	TNFRSF1A associated via death domain.	0.982
BIRC2	TRAF2	ENSUAMP00000018421	ENSUAMP00000001957	Baculoviral IAP repeat containing 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.969
CASP8	BIRC2	ENSUAMP00000007996	ENSUAMP00000018421	Caspase 8; Belongs to the peptidase C14A family.	Baculoviral IAP repeat containing 2.	0.493
CASP8	FADD	ENSUAMP00000007996	ENSUAMP00000027565	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	RIPK1	ENSUAMP00000007996	ENSUAMP00000019468	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.998
CASP8	RIPK3	ENSUAMP00000007996	ENSUAMP00000032010	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily.	0.997
CASP8	TRADD	ENSUAMP00000007996	ENSUAMP00000019860	Caspase 8; Belongs to the peptidase C14A family.	TNFRSF1A associated via death domain.	0.996
CASP8	TRAF2	ENSUAMP00000007996	ENSUAMP00000001957	Caspase 8; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.902
FADD	BIRC2	ENSUAMP00000027565	ENSUAMP00000018421	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Baculoviral IAP repeat containing 2.	0.959
FADD	CASP8	ENSUAMP00000027565	ENSUAMP00000007996	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 8; Belongs to the peptidase C14A family.	0.999
FADD	RIPK1	ENSUAMP00000027565	ENSUAMP00000019468	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.999
FADD	RIPK3	ENSUAMP00000027565	ENSUAMP00000032010	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily.	0.992
FADD	TRADD	ENSUAMP00000027565	ENSUAMP00000019860	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNFRSF1A associated via death domain.	0.999
FADD	TRAF2	ENSUAMP00000027565	ENSUAMP00000001957	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.968
RIPK1	BIRC2	ENSUAMP00000019468	ENSUAMP00000018421	Receptor interacting serine/threonine kinase 1.	Baculoviral IAP repeat containing 2.	0.980
RIPK1	CASP8	ENSUAMP00000019468	ENSUAMP00000007996	Receptor interacting serine/threonine kinase 1.	Caspase 8; Belongs to the peptidase C14A family.	0.998