(12 nodes) Mixed, incl. Endodermal cell fate specification, and Male sex determination network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000000316	Homeobox domain-containing protein. (280 aa)
	sry	Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family. (221 aa)
	ENSUAMP00000001583	annotation not available (221 aa)
	SALL4	Spalt like transcription factor 4. (1053 aa)
	ENSUAMP00000014216	Homeobox domain-containing protein. (315 aa)
	ENSUAMP00000015591	Uncharacterized protein. (184 aa)
	ENSUAMP00000016349	Uncharacterized protein. (121 aa)
	KLF4	Kruppel like factor 4. (487 aa)
	SOX2	SRY-box transcription factor 2. (321 aa)
	ENSUAMP00000035029	POU domain protein. (360 aa)
	SOX17	SRY-box transcription factor 17. (406 aa)
	EOMES	Eomesodermin. (687 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000000316	ENSUAMP00000001583	ENSUAMP00000000316	ENSUAMP00000001583	Homeobox domain-containing protein.	annotation not available	0.401
ENSUAMP00000000316	ENSUAMP00000014216	ENSUAMP00000000316	ENSUAMP00000014216	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.703
ENSUAMP00000000316	ENSUAMP00000015591	ENSUAMP00000000316	ENSUAMP00000015591	Homeobox domain-containing protein.	Uncharacterized protein.	0.471
ENSUAMP00000000316	ENSUAMP00000016349	ENSUAMP00000000316	ENSUAMP00000016349	Homeobox domain-containing protein.	Uncharacterized protein.	0.471
ENSUAMP00000000316	ENSUAMP00000035029	ENSUAMP00000000316	ENSUAMP00000035029	Homeobox domain-containing protein.	POU domain protein.	0.471
ENSUAMP00000000316	EOMES	ENSUAMP00000000316	ENSUAMP00000036778	Homeobox domain-containing protein.	Eomesodermin.	0.617
ENSUAMP00000000316	SOX17	ENSUAMP00000000316	ENSUAMP00000036659	Homeobox domain-containing protein.	SRY-box transcription factor 17.	0.713
ENSUAMP00000000316	SOX2	ENSUAMP00000000316	ENSUAMP00000023439	Homeobox domain-containing protein.	SRY-box transcription factor 2.	0.401
ENSUAMP00000000316	sry	ENSUAMP00000000316	ENSUAMP00000001553	Homeobox domain-containing protein.	Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family.	0.401
ENSUAMP00000001583	ENSUAMP00000000316	ENSUAMP00000001583	ENSUAMP00000000316	annotation not available	Homeobox domain-containing protein.	0.401
ENSUAMP00000001583	ENSUAMP00000014216	ENSUAMP00000001583	ENSUAMP00000014216	annotation not available	Homeobox domain-containing protein.	0.746
ENSUAMP00000001583	ENSUAMP00000015591	ENSUAMP00000001583	ENSUAMP00000015591	annotation not available	Uncharacterized protein.	0.712
ENSUAMP00000001583	ENSUAMP00000016349	ENSUAMP00000001583	ENSUAMP00000016349	annotation not available	Uncharacterized protein.	0.712
ENSUAMP00000001583	ENSUAMP00000035029	ENSUAMP00000001583	ENSUAMP00000035029	annotation not available	POU domain protein.	0.712
ENSUAMP00000001583	SALL4	ENSUAMP00000001583	ENSUAMP00000012488	annotation not available	Spalt like transcription factor 4.	0.524
ENSUAMP00000014216	ENSUAMP00000000316	ENSUAMP00000014216	ENSUAMP00000000316	Homeobox domain-containing protein.	Homeobox domain-containing protein.	0.703
ENSUAMP00000014216	ENSUAMP00000001583	ENSUAMP00000014216	ENSUAMP00000001583	Homeobox domain-containing protein.	annotation not available	0.746
ENSUAMP00000014216	ENSUAMP00000015591	ENSUAMP00000014216	ENSUAMP00000015591	Homeobox domain-containing protein.	Uncharacterized protein.	0.893
ENSUAMP00000014216	ENSUAMP00000016349	ENSUAMP00000014216	ENSUAMP00000016349	Homeobox domain-containing protein.	Uncharacterized protein.	0.893
ENSUAMP00000014216	ENSUAMP00000035029	ENSUAMP00000014216	ENSUAMP00000035029	Homeobox domain-containing protein.	POU domain protein.	0.893