STRINGSTRING
EGR1 EGR1 ENSUAMP00000000424 ENSUAMP00000000424 PGR PGR EGR2 EGR2 ENSUAMP00000001355 ENSUAMP00000001355 PPARG PPARG ATF5 ATF5 NR1H3 NR1H3 BATF3 BATF3 ATF3 ATF3 RARG RARG HIF3A HIF3A ENSUAMP00000004542 ENSUAMP00000004542 ATF4 ATF4 TRIB3 TRIB3 CREM CREM PER1 PER1 ENSUAMP00000006139 ENSUAMP00000006139 ESR1 ESR1 MTFR2 MTFR2 CARM1 CARM1 NPAS2 NPAS2 NCOA1 NCOA1 JUN JUN ENSUAMP00000009120 ENSUAMP00000009120 CEBPG CEBPG ATF2 ATF2 EPAS1 EPAS1 MAFB MAFB PPARA PPARA ENSUAMP00000011014 ENSUAMP00000011014 CIART CIART ARC ARC COQ10B COQ10B ARNT ARNT RARB RARB SP1 SP1 CEBPD CEBPD CSNK1D CSNK1D CIPC CIPC BATF2 BATF2 NR4A2 NR4A2 ENSUAMP00000015788 ENSUAMP00000015788 PER2 PER2 ATF1 ATF1 NAB1 NAB1 ENSUAMP00000016793 ENSUAMP00000016793 NR4A3 NR4A3 JDP2 JDP2 BATF BATF ENSUAMP00000017404 ENSUAMP00000017404 ENSUAMP00000017524 ENSUAMP00000017524 RPS6KA5 RPS6KA5 CAMKK1 CAMKK1 NR1H2 NR1H2 TBL1XR1 TBL1XR1 ESRRA ESRRA NR1D1 NR1D1 THRA THRA IER2 IER2 NR1D2 NR1D2 ENSUAMP00000020485 ENSUAMP00000020485 ATF6B ATF6B KLF9 KLF9 ENSUAMP00000021701 ENSUAMP00000021701 ENSUAMP00000022260 ENSUAMP00000022260 ENSUAMP00000023165 ENSUAMP00000023165 ESRRG ESRRG CRY2 CRY2 CREB1 CREB1 EGR4 EGR4 CREB3L3 CREB3L3 NCOA3 NCOA3 ENSUAMP00000025159 ENSUAMP00000025159 ENSUAMP00000025215 ENSUAMP00000025215 NCOR1 NCOR1 ENSUAMP00000025261 ENSUAMP00000025261 ATF6 ATF6 FOSB FOSB CREB5 CREB5 RXRA RXRA FBXL3 FBXL3 FOSL1 FOSL1 PPARGC1A PPARGC1A EGLN3 EGLN3 CEBPB CEBPB NAB2 NAB2 THRB THRB ENSUAMP00000027844 ENSUAMP00000027844 ENSUAMP00000027845 ENSUAMP00000027845 ENSUAMP00000028186 ENSUAMP00000028186 ENSUAMP00000028801 ENSUAMP00000028801 ENSUAMP00000028802 ENSUAMP00000028802 ARNTL ARNTL WFS1 WFS1 KLF5 KLF5 NRF1 NRF1 RPS6KA4 RPS6KA4 CREBBP CREBBP NCOR2 NCOR2 CREB3L4 CREB3L4 EP300 EP300 CEBPE CEBPE NFIL3 NFIL3 GFI1B GFI1B ARNT2 ARNT2 EGR3 EGR3 ENSUAMP00000032843 ENSUAMP00000032843 DDIT3 DDIT3 NPAS1 NPAS1 TEF TEF NR0B2 NR0B2 FOSL2 FOSL2 HIF1A HIF1A ENSUAMP00000034574 ENSUAMP00000034574 CRY1 CRY1 ENSUAMP00000034960 ENSUAMP00000034960 CREB3L1 CREB3L1 ENSUAMP00000035192 ENSUAMP00000035192 ENSUAMP00000035193 ENSUAMP00000035193 NCOA2 NCOA2 CREB3 CREB3 MSMP MSMP RXRB RXRB NPAS4 NPAS4 ENSUAMP00000037224 ENSUAMP00000037224 HDAC3 HDAC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
ENSUAMP00000000424Uncharacterized protein. (250 aa)
PGRProgesterone receptor. (634 aa)
EGR2Early growth response 2. (471 aa)
ENSUAMP00000001355Uncharacterized protein. (218 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
ATF5Activating transcription factor 5. (276 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (122 aa)
ATF3Activating transcription factor 3. (181 aa)
RARGRetinoic acid receptor gamma. (458 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (645 aa)
ENSUAMP00000004542Uncharacterized protein. (171 aa)
ATF4Activating transcription factor 4. (351 aa)
TRIB3Tribbles pseudokinase 3. (363 aa)
CREMcAMP responsive element modulator. (269 aa)
PER1Period circadian regulator 1. (1293 aa)
ENSUAMP00000006139BHLH domain-containing protein. (282 aa)
ESR1Estrogen receptor 1. (490 aa)
MTFR2Mitochondrial fission regulator 2. (353 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (636 aa)
NPAS2Neuronal PAS domain protein 2. (822 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
ENSUAMP00000009120Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (436 aa)
CEBPGCCAAT enhancer binding protein gamma. (147 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
EPAS1Endothelial PAS domain protein 1. (863 aa)
MAFBMAF bZIP transcription factor B. (323 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
ENSUAMP00000011014Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (474 aa)
CIARTCircadian associated repressor of transcription. (385 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
COQ10BCoenzyme Q10B. (232 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (481 aa)
RARBRetinoic acid receptor beta. (336 aa)
SP1Sp1 transcription factor. (780 aa)
CEBPDCCAAT/enhancer-binding protein. (273 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
CIPCCLOCK interacting pacemaker. (399 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (281 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
ENSUAMP00000015788BZIP domain-containing protein. (359 aa)
PER2Period circadian regulator 2. (1267 aa)
ATF1Activating transcription factor 1. (270 aa)
NAB1NGFI-A binding protein 1. (486 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (619 aa)
JDP2Jun dimerization protein 2. (187 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
ENSUAMP00000017404Fe2OG dioxygenase domain-containing protein. (125 aa)
ENSUAMP00000017524Uncharacterized protein. (542 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (508 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (455 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (520 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (600 aa)
THRAThyroid hormone receptor alpha. (511 aa)
IER2Immediate early response 2. (222 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (546 aa)
ENSUAMP00000020485Protein kinase domain-containing protein. (108 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
KLF9Kruppel like factor 9. (244 aa)
ENSUAMP00000021701Fe2OG dioxygenase domain-containing protein. (233 aa)
ENSUAMP00000022260Uncharacterized protein. (154 aa)
ENSUAMP00000023165Protein kinase domain-containing protein. (270 aa)
ESRRGEstrogen related receptor gamma. (435 aa)
CRY2Cryptochrome circadian regulator 2. (604 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
EGR4Early growth response 4. (484 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (457 aa)
NCOA3Nuclear receptor coactivator. (1431 aa)
ENSUAMP00000025159BZIP domain-containing protein. (314 aa)
ENSUAMP00000025215BZIP domain-containing protein. (347 aa)
NCOR1Nuclear receptor corepressor 1. (2267 aa)
ENSUAMP00000025261GPS2_interact domain-containing protein. (204 aa)
ATF6BZIP domain-containing protein. (477 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
CREB5cAMP responsive element binding protein 5. (327 aa)
RXRARetinoid X receptor alpha. (469 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
PPARGC1APPARG coactivator 1 alpha. (761 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
NAB2NGFI-A binding protein 2. (492 aa)
THRBThyroid hormone receptor beta. (467 aa)
ENSUAMP00000027844Nuc_recep-AF1 domain-containing protein. (202 aa)
ENSUAMP00000027845Uncharacterized protein. (347 aa)
ENSUAMP00000028186Uncharacterized protein. (505 aa)
ENSUAMP00000028801BHLH domain-containing protein. (234 aa)
ENSUAMP00000028802Uncharacterized protein. (566 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (626 aa)
WFS1Wolframin ER transmembrane glycoprotein. (888 aa)
KLF5Kruppel like factor 5. (442 aa)
NRF1Nuclear respiratory factor 1. (503 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
CREBBPCREB binding protein. (2333 aa)
NCOR2Nuclear receptor corepressor 2. (2465 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (247 aa)
EP300E1A binding protein p300. (2399 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
NFIL3Nuclear factor, interleukin 3 regulated. (462 aa)
GFI1BGrowth factor independent 1B transcriptional repressor. (362 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (706 aa)
EGR3Early growth response 3. (387 aa)
ENSUAMP00000032843Uncharacterized protein. (186 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
NPAS1Neuronal PAS domain protein 1. (604 aa)
TEFTEF transcription factor, PAR bZIP family member. (299 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (301 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (325 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
ENSUAMP00000034574Uncharacterized protein. (525 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
ENSUAMP00000034960C2H2-type domain-containing protein. (123 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
ENSUAMP00000035192Uncharacterized protein. (82 aa)
ENSUAMP00000035193Uncharacterized protein. (279 aa)
NCOA2Nuclear receptor coactivator 2. (945 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
MSMPBeta-microseminoprotein. (139 aa)
RXRBRetinoid X receptor beta. (532 aa)
NPAS4Neuronal PAS domain protein 4. (800 aa)
ENSUAMP00000037224Fe2OG dioxygenase domain-containing protein. (126 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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