26 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	PGR	Progesterone receptor. (634 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (447 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	CARM1	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (636 aa)
	NCOA1	Nuclear receptor coactivator. (1441 aa)
	RARB	Retinoic acid receptor beta. (336 aa)
	SP1	Sp1 transcription factor. (780 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (455 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (520 aa)
	THRA	Thyroid hormone receptor alpha. (511 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (546 aa)
	ENSUAMP00000022260	Uncharacterized protein. (154 aa)
	NCOA3	Nuclear receptor coactivator. (1431 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	RXRA	Retinoid X receptor alpha. (469 aa)
	THRB	Thyroid hormone receptor beta. (467 aa)
	ENSUAMP00000027844	Nuc_recep-AF1 domain-containing protein. (202 aa)
	ENSUAMP00000027845	Uncharacterized protein. (347 aa)
	NCOR2	Nuclear receptor corepressor 2. (2465 aa)
	ENSUAMP00000034574	Uncharacterized protein. (525 aa)
	NCOA2	Nuclear receptor coactivator 2. (945 aa)
	RXRB	Retinoid X receptor beta. (532 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARM1	ENSUAMP00000022260	ENSUAMP00000007500	ENSUAMP00000022260	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Uncharacterized protein.	0.472
CARM1	ENSUAMP00000025261	ENSUAMP00000007500	ENSUAMP00000025261	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	GPS2_interact domain-containing protein.	0.519
CARM1	ENSUAMP00000027844	ENSUAMP00000007500	ENSUAMP00000027844	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuc_recep-AF1 domain-containing protein.	0.445
CARM1	ENSUAMP00000027845	ENSUAMP00000007500	ENSUAMP00000027845	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Uncharacterized protein.	0.445
CARM1	ENSUAMP00000034574	ENSUAMP00000007500	ENSUAMP00000034574	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Uncharacterized protein.	0.512
CARM1	ESR1	ENSUAMP00000007500	ENSUAMP00000006270	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Estrogen receptor 1.	0.969
CARM1	HDAC3	ENSUAMP00000007500	ENSUAMP00000037450	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.524
CARM1	NCOA1	ENSUAMP00000007500	ENSUAMP00000008682	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.770
CARM1	NCOA2	ENSUAMP00000007500	ENSUAMP00000035278	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator 2.	0.789
CARM1	NCOA3	ENSUAMP00000007500	ENSUAMP00000025028	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.984
CARM1	NCOR1	ENSUAMP00000007500	ENSUAMP00000025256	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor corepressor 1.	0.519
CARM1	NCOR2	ENSUAMP00000007500	ENSUAMP00000030789	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor corepressor 2.	0.573
CARM1	PPARG	ENSUAMP00000007500	ENSUAMP00000002284	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.431
CARM1	RXRA	ENSUAMP00000007500	ENSUAMP00000026794	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Retinoid X receptor alpha.	0.467
CARM1	RXRB	ENSUAMP00000007500	ENSUAMP00000035462	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Retinoid X receptor beta.	0.445
CARM1	SP1	ENSUAMP00000007500	ENSUAMP00000013622	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Sp1 transcription factor.	0.929
CARM1	TBL1XR1	ENSUAMP00000007500	ENSUAMP00000019057	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Transducin beta like 1 X-linked receptor 1.	0.512
ENSUAMP00000022260	CARM1	ENSUAMP00000022260	ENSUAMP00000007500	Uncharacterized protein.	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.472
ENSUAMP00000022260	ENSUAMP00000025261	ENSUAMP00000022260	ENSUAMP00000025261	Uncharacterized protein.	GPS2_interact domain-containing protein.	0.822
ENSUAMP00000022260	ENSUAMP00000034574	ENSUAMP00000022260	ENSUAMP00000034574	Uncharacterized protein.	Uncharacterized protein.	0.939