20 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (447 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	RARB	Retinoic acid receptor beta. (336 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (455 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (520 aa)
	THRA	Thyroid hormone receptor alpha. (511 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (546 aa)
	ENSUAMP00000022260	Uncharacterized protein. (154 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	RXRA	Retinoid X receptor alpha. (469 aa)
	THRB	Thyroid hormone receptor beta. (467 aa)
	ENSUAMP00000027844	Nuc_recep-AF1 domain-containing protein. (202 aa)
	ENSUAMP00000027845	Uncharacterized protein. (347 aa)
	NCOR2	Nuclear receptor corepressor 2. (2465 aa)
	ENSUAMP00000034574	Uncharacterized protein. (525 aa)
	NCOA2	Nuclear receptor coactivator 2. (945 aa)
	RXRB	Retinoid X receptor beta. (532 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000022260	ENSUAMP00000025261	ENSUAMP00000022260	ENSUAMP00000025261	Uncharacterized protein.	GPS2_interact domain-containing protein.	0.822
ENSUAMP00000022260	ENSUAMP00000034574	ENSUAMP00000022260	ENSUAMP00000034574	Uncharacterized protein.	Uncharacterized protein.	0.939
ENSUAMP00000022260	HDAC3	ENSUAMP00000022260	ENSUAMP00000037450	Uncharacterized protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.970
ENSUAMP00000022260	NCOR1	ENSUAMP00000022260	ENSUAMP00000025256	Uncharacterized protein.	Nuclear receptor corepressor 1.	0.822
ENSUAMP00000022260	NCOR2	ENSUAMP00000022260	ENSUAMP00000030789	Uncharacterized protein.	Nuclear receptor corepressor 2.	0.826
ENSUAMP00000022260	NR1H2	ENSUAMP00000022260	ENSUAMP00000018908	Uncharacterized protein.	Nuclear receptor subfamily 1 group H member 2.	0.500
ENSUAMP00000022260	NR1H3	ENSUAMP00000022260	ENSUAMP00000003082	Uncharacterized protein.	Nuclear receptor subfamily 1 group H member 3.	0.500
ENSUAMP00000022260	RXRA	ENSUAMP00000022260	ENSUAMP00000026794	Uncharacterized protein.	Retinoid X receptor alpha.	0.502
ENSUAMP00000022260	RXRB	ENSUAMP00000022260	ENSUAMP00000035462	Uncharacterized protein.	Retinoid X receptor beta.	0.516
ENSUAMP00000022260	TBL1XR1	ENSUAMP00000022260	ENSUAMP00000019057	Uncharacterized protein.	Transducin beta like 1 X-linked receptor 1.	0.939
ENSUAMP00000025261	ENSUAMP00000022260	ENSUAMP00000025261	ENSUAMP00000022260	GPS2_interact domain-containing protein.	Uncharacterized protein.	0.822
ENSUAMP00000025261	ENSUAMP00000027844	ENSUAMP00000025261	ENSUAMP00000027844	GPS2_interact domain-containing protein.	Nuc_recep-AF1 domain-containing protein.	0.907
ENSUAMP00000025261	ENSUAMP00000027845	ENSUAMP00000025261	ENSUAMP00000027845	GPS2_interact domain-containing protein.	Uncharacterized protein.	0.907
ENSUAMP00000025261	ENSUAMP00000034574	ENSUAMP00000025261	ENSUAMP00000034574	GPS2_interact domain-containing protein.	Uncharacterized protein.	0.864
ENSUAMP00000025261	HDAC3	ENSUAMP00000025261	ENSUAMP00000037450	GPS2_interact domain-containing protein.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.988
ENSUAMP00000025261	NCOA2	ENSUAMP00000025261	ENSUAMP00000035278	GPS2_interact domain-containing protein.	Nuclear receptor coactivator 2.	0.623
ENSUAMP00000025261	NCOR2	ENSUAMP00000025261	ENSUAMP00000030789	GPS2_interact domain-containing protein.	Nuclear receptor corepressor 2.	0.905
ENSUAMP00000025261	NR1D2	ENSUAMP00000025261	ENSUAMP00000019629	GPS2_interact domain-containing protein.	Nuclear receptor subfamily 1 group D member 2.	0.916
ENSUAMP00000025261	NR1H2	ENSUAMP00000025261	ENSUAMP00000018908	GPS2_interact domain-containing protein.	Nuclear receptor subfamily 1 group H member 2.	0.666
ENSUAMP00000025261	NR1H3	ENSUAMP00000025261	ENSUAMP00000003082	GPS2_interact domain-containing protein.	Nuclear receptor subfamily 1 group H member 3.	0.666