(57 nodes) Citrate cycle (TCA cycle), and Regulation of pyruvate dehydrogenase (PDH) complex network (Ursus americanus)

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	PDPR	Pyruvate dehydrogenase phosphatase regulatory subunit. (872 aa)
	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (463 aa)
	SUCLG1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
	ENSUAMP00000005308	DAO domain-containing protein. (175 aa)
	IDH3B	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
	PDK4	Protein-serine/threonine kinase. (412 aa)
	PDP2	Pyruvate dehyrogenase phosphatase catalytic subunit 2. (539 aa)
	GPT	Glutamic--pyruvic transaminase. (622 aa)
	BCKDHB	Branched chain keto acid dehydrogenase E1 subunit beta. (318 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (421 aa)
	PC	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1190 aa)
	GOT2	Aspartate aminotransferase. (393 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	ENSUAMP00000012476	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (466 aa)
	ENSUAMP00000012538	2-oxoacid_dh domain-containing protein. (170 aa)
	ENSUAMP00000012541	Uncharacterized protein. (98 aa)
	DLD	Dihydrolipoyl dehydrogenase. (509 aa)
	ENSUAMP00000013191	CN hydrolase domain-containing protein. (91 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	ENSUAMP00000014859	Iso_dh domain-containing protein. (372 aa)
	FAHD1	Fumarylacetoacetate hydrolase domain containing 1. (221 aa)
	MDH1	Malate dehydrogenase. (321 aa)
	ENSUAMP00000017059	2-oxoacid_dh domain-containing protein. (248 aa)
	OGDH	Oxoglutarate dehydrogenase. (1083 aa)
	URB2	URB2 ribosome biogenesis homolog. (1521 aa)
	OGDHL	Oxoglutarate dehydrogenase like. (1025 aa)
	IDH3G	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (395 aa)
	GPT2	Glutamic--pyruvic transaminase 2. (559 aa)
	DBT	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
	SDHAF2	Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
	IDH3A	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (380 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
	ENSUAMP00000023721	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
	FH	Fumarate hydratase. (493 aa)
	ENSUAMP00000024931	Uncharacterized protein. (162 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	PDK3	Protein-serine/threonine kinase. (382 aa)
	ACO1	Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
	PDHX	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
	ENSUAMP00000028021	Uncharacterized protein. (135 aa)
	ENSUAMP00000028798	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
	ACO2	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (799 aa)
	GOT1L1	Glutamic-oxaloacetic transaminase 1 like 1. (406 aa)
	DHTKD1	Dehydrogenase E1 and transketolase domain containing 1. (920 aa)
	PDP1	Pyruvate dehyrogenase phosphatase catalytic subunit 1. (591 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	ENSUAMP00000031664	annotation not available (372 aa)
	PDK1	Protein-serine/threonine kinase. (438 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
	SDHB	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (254 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
	ENSUAMP00000032873	CN hydrolase domain-containing protein. (283 aa)
	ENSUAMP00000033428	Uncharacterized protein. (169 aa)
	CS	Citrate synthase; Belongs to the citrate synthase family. (466 aa)
	PDK2	Protein-serine/threonine kinase. (249 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
	PDHA2	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	ACO1	ENSUAMP00000032191	ENSUAMP00000026754	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aconitase 1; Belongs to the aconitase/IPM isomerase family.	0.972
ACLY	ACO2	ENSUAMP00000032191	ENSUAMP00000029308	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.933
ACLY	BCKDHB	ENSUAMP00000032191	ENSUAMP00000008908	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.473
ACLY	CS	ENSUAMP00000032191	ENSUAMP00000035206	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Citrate synthase; Belongs to the citrate synthase family.	0.998
ACLY	DBT	ENSUAMP00000032191	ENSUAMP00000021934	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.843
ACLY	DHTKD1	ENSUAMP00000032191	ENSUAMP00000030843	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Dehydrogenase E1 and transketolase domain containing 1.	0.912
ACLY	DLAT	ENSUAMP00000032191	ENSUAMP00000023716	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.986
ACLY	DLD	ENSUAMP00000032191	ENSUAMP00000013114	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Dihydrolipoyl dehydrogenase.	0.739
ACLY	ENSUAMP00000005308	ENSUAMP00000032191	ENSUAMP00000005308	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	DAO domain-containing protein.	0.944
ACLY	ENSUAMP00000012476	ENSUAMP00000032191	ENSUAMP00000012476	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.537
ACLY	ENSUAMP00000012538	ENSUAMP00000032191	ENSUAMP00000012538	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	2-oxoacid_dh domain-containing protein.	0.850
ACLY	ENSUAMP00000012541	ENSUAMP00000032191	ENSUAMP00000012541	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uncharacterized protein.	0.850
ACLY	ENSUAMP00000013191	ENSUAMP00000032191	ENSUAMP00000013191	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	CN hydrolase domain-containing protein.	0.884
ACLY	ENSUAMP00000014859	ENSUAMP00000032191	ENSUAMP00000014859	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Iso_dh domain-containing protein.	0.440
ACLY	ENSUAMP00000017059	ENSUAMP00000032191	ENSUAMP00000017059	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	2-oxoacid_dh domain-containing protein.	0.850
ACLY	ENSUAMP00000023721	ENSUAMP00000032191	ENSUAMP00000023721	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family.	0.589
ACLY	ENSUAMP00000024931	ENSUAMP00000032191	ENSUAMP00000024931	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uncharacterized protein.	0.896
ACLY	ENSUAMP00000028021	ENSUAMP00000032191	ENSUAMP00000028021	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uncharacterized protein.	0.896
ACLY	ENSUAMP00000028798	ENSUAMP00000032191	ENSUAMP00000028798	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.963
ACLY	ENSUAMP00000031664	ENSUAMP00000032191	ENSUAMP00000031664	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	annotation not available	0.440