STRINGSTRING
LIAS LIAS MTAP MTAP ENSUAMP00000001521 ENSUAMP00000001521 TYMS TYMS PSPH PSPH ENSUAMP00000003272 ENSUAMP00000003272 AHCYL2 AHCYL2 GLDC GLDC ALAS2 ALAS2 ENSUAMP00000005677 ENSUAMP00000005677 ENSUAMP00000006222 ENSUAMP00000006222 MAT2B MAT2B ACCS ACCS HLCS HLCS ENSUAMP00000007782 ENSUAMP00000007782 AHCY AHCY AMT AMT APIP APIP CTH CTH ADD2 ADD2 LIPT2 LIPT2 THNSL1 THNSL1 PSAT1 PSAT1 LIPT1 LIPT1 ENSUAMP00000012599 ENSUAMP00000012599 ENSUAMP00000012825 ENSUAMP00000012825 SHMT1 SHMT1 BTD BTD ENOPH1 ENOPH1 ENSUAMP00000015652 ENSUAMP00000015652 MAT1A MAT1A ENSUAMP00000016283 ENSUAMP00000016283 ENSUAMP00000016284 ENSUAMP00000016284 MTHFD1L MTHFD1L PIPOX PIPOX MRI1 MRI1 MTHFD2 MTHFD2 GNMT GNMT ADI1 ADI1 ENSUAMP00000023340 ENSUAMP00000023340 MTR MTR ENSUAMP00000023441 ENSUAMP00000023441 SARDH SARDH ALDH1L1 ALDH1L1 MTHFR MTHFR THNSL2 THNSL2 ENSUAMP00000024912 ENSUAMP00000024912 ENSUAMP00000024913 ENSUAMP00000024913 ENSUAMP00000025515 ENSUAMP00000025515 GCAT GCAT ALAS1 ALAS1 SHMT2 SHMT2 ENSUAMP00000027384 ENSUAMP00000027384 MTHFD1 MTHFD1 AHCYL1 AHCYL1 ENSUAMP00000029554 ENSUAMP00000029554 FPGS FPGS DMGDH DMGDH BHMT2 BHMT2 BHMT BHMT ENSUAMP00000032448 ENSUAMP00000032448 PHGDH PHGDH SRR SRR ENSUAMP00000034153 ENSUAMP00000034153 ENSUAMP00000034957 ENSUAMP00000034957 TAT TAT MAT2A MAT2A ENSUAMP00000037302 ENSUAMP00000037302 SDS SDS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
MTAPS-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (255 aa)
ENSUAMP00000001521Lipoyl-binding domain-containing protein. (129 aa)
TYMSThymidylate synthetase. (342 aa)
PSPHPhosphoserine phosphatase. (225 aa)
ENSUAMP00000003272SHMT domain-containing protein. (59 aa)
AHCYL2Adenosylhomocysteinase like 2. (436 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (991 aa)
ALAS25-aminolevulinate synthase. (587 aa)
ENSUAMP00000005677Aldedh domain-containing protein. (169 aa)
ENSUAMP00000006222Carrier domain-containing protein. (376 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (324 aa)
ACCS1-aminocyclopropane-1-carboxylate synthase homolog (inactive). (501 aa)
HLCSHolocarboxylase synthetase. (670 aa)
ENSUAMP00000007782Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (156 aa)
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (445 aa)
AMTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa)
APIPAPAF1 interacting protein. (199 aa)
CTHCystathionine gamma-lyase. (409 aa)
ADD2Adducin 2. (710 aa)
LIPT2Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (231 aa)
THNSL1Threonine synthase like 1. (743 aa)
PSAT1Phosphoserine aminotransferase. (334 aa)
LIPT1Lipoyltransferase 1. (373 aa)
ENSUAMP00000012599Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (573 aa)
ENSUAMP00000012825Uncharacterized protein. (106 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
BTDBiotinidase. (523 aa)
ENOPH1Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (261 aa)
ENSUAMP00000015652Aldolase_II domain-containing protein. (400 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
ENSUAMP00000016283THF_DHG_CYH_C domain-containing protein. (169 aa)
ENSUAMP00000016284THF_DHG_CYH domain-containing protein. (106 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (961 aa)
PIPOXPipecolic acid and sarcosine oxidase. (386 aa)
MRI1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (384 aa)
MTHFD2Uncharacterized protein. (350 aa)
GNMTGlycine N-methyltransferase. (295 aa)
ADI11,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (179 aa)
ENSUAMP00000023340DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa)
ENSUAMP00000023441DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
SARDHSarcosine dehydrogenase. (601 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (930 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa)
THNSL2Threonine synthase like 2. (435 aa)
ENSUAMP00000024912Uncharacterized protein. (239 aa)
ENSUAMP00000024913Uncharacterized protein. (198 aa)
ENSUAMP00000025515THF_DHG_CYH domain-containing protein. (106 aa)
GCATGlycine C-acetyltransferase. (419 aa)
ALAS15-aminolevulinate synthase. (640 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
ENSUAMP00000027384Beta_elim_lyase domain-containing protein. (401 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (992 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
ENSUAMP00000029554Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (159 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (579 aa)
DMGDHDimethylglycine dehydrogenase. (866 aa)
BHMT2Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa)
BHMTBetaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa)
ENSUAMP000000324485-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (203 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
SRRSerine racemase. (339 aa)
ENSUAMP00000034153Epimerase domain-containing protein. (268 aa)
ENSUAMP00000034957Uncharacterized protein. (149 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
ENSUAMP00000037302FTCD_N domain-containing protein. (197 aa)
SDSSerine dehydratase. (328 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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