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| | NT5C1A | 5'-nucleotidase, cytosolic IA. (366 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (547 aa) |
| | PDE7A | Phosphodiesterase. (457 aa) |
| | ENSUAMP00000001002 | Uncharacterized protein. (86 aa) |
| | DUT | Deoxyuridine triphosphatase. (175 aa) |
| | UPRT | Uracil phosphoribosyltransferase homolog. (306 aa) |
| | ADA2 | Adenosine deaminase 2. (515 aa) |
| | ENSUAMP00000002393 | Uncharacterized protein. (57 aa) |
| | ENSUAMP00000003186 | Uncharacterized protein. (52 aa) |
| | AK3 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (235 aa) |
| | NTPCR | Nucleoside-triphosphatase, cancer-related. (198 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (291 aa) |
| | ENSUAMP00000004451 | IMPDH domain-containing protein. (161 aa) |
| | NME1 | Nucleoside diphosphate kinase. (152 aa) |
| | NME2 | Nucleoside diphosphate kinase. (159 aa) |
| | DCTPP1 | dCTP pyrophosphatase 1. (220 aa) |
| | CANT1 | Calcium activated nucleotidase 1. (401 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | NUDT2 | Nudix hydrolase 2. (148 aa) |
| | NT5M | 5',3'-nucleotidase, mitochondrial. (193 aa) |
| | CDADC1 | Cytidine and dCMP deaminase domain containing 1. (499 aa) |
| | ENSUAMP00000007133 | Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (283 aa) |
| | ENSUAMP00000007406 | PDEase domain-containing protein. (173 aa) |
| | TK2 | Thymidine kinase 2. (216 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (799 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (493 aa) |
| | IMPDH1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (609 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (463 aa) |
| | THTPA | Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (230 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (594 aa) |
| | DTYMK | Deoxythymidylate kinase. (261 aa) |
| | ADSS1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa) |
| | UCK1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (276 aa) |
| | ENSUAMP00000010849 | PDE4_UCR domain-containing protein. (136 aa) |
| | AK3-2 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (283 aa) |
| | AK3-3 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (235 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (863 aa) |
| | PDE1B | Phosphodiesterase. (535 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (215 aa) |
| | GLRX | Glutaredoxin. (106 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (209 aa) |
| | NT5C | 5', 3'-nucleotidase, cytosolic. (207 aa) |
| | NT5E | 5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (528 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (446 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | DCTD | dCMP deaminase. (183 aa) |
| | NME3 | Nucleoside diphosphate kinase. (169 aa) |
| | ENSUAMP00000016857 | Uncharacterized protein. (76 aa) |
| | UCK2 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (336 aa) |
| | XDH | Xanthine dehydrogenase. (1313 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (498 aa) |
| | UPP1 | Uridine phosphorylase 1. (316 aa) |
| | GART | Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1006 aa) |
| | ADK | Adenosine kinase. (311 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa) |
| | GMPS | Guanine monophosphate synthase. (693 aa) |
| | NME4 | Nucleoside diphosphate kinase. (187 aa) |
| | ENSUAMP00000020703 | TPK_catalytic domain-containing protein. (251 aa) |
| | DGUOK | Deoxyguanosine kinase. (291 aa) |
| | ENSUAMP00000020992 | ATP-cone domain-containing protein. (123 aa) |
| | PDE3A | Phosphodiesterase. (777 aa) |
| | ENSUAMP00000021520 | Uncharacterized protein. (210 aa) |
| | ADA | Adenosine deaminase. (385 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | ENSUAMP00000022722 | Uncharacterized protein. (223 aa) |
| | ENSUAMP00000022965 | Uncharacterized protein. (296 aa) |
| | ENSUAMP00000023031 | Uncharacterized protein. (118 aa) |
| | AK6 | Adenylate kinase 6. (141 aa) |
| | ENSUAMP00000024989 | Amidohydro-rel domain-containing protein. (223 aa) |
| | HDDC3 | HD domain containing 3. (179 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (743 aa) |
| | TK1 | Thymidine kinase. (239 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (775 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (297 aa) |
| | ENSUAMP00000028238 | PNP_UDP_1 domain-containing protein. (96 aa) |
| | ENTPD2 | Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | ENSUAMP00000029679 | Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (868 aa) |
| | AK1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (245 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (636 aa) |
| | NME6 | Nucleoside diphosphate kinase. (186 aa) |
| | PDE4D | Phosphodiesterase. (585 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (361 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa) |
| | ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa) |
| | ENSUAMP00000032197 | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa) |
| | ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (533 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa) |
| | PDE10A | Phosphodiesterase. (525 aa) |
| | PKM | Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa) |
| | AK7 | Adenylate kinase 7. (718 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | PDE1A | Phosphodiesterase. (518 aa) |
| | ENSUAMP00000034716 | Uncharacterized protein. (118 aa) |
| | ENSUAMP00000034767 | Uncharacterized protein; Belongs to the adenylate kinase family. (120 aa) |
| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa) |
| | ENSUAMP00000035827 | Uncharacterized protein. (175 aa) |
| | DCK | Deoxycytidine kinase. (260 aa) |
| | ENSUAMP00000036669 | Uncharacterized protein. (166 aa) |
| | PDE2A | Phosphodiesterase. (975 aa) |
| | PAICS | AIRC domain-containing protein. (412 aa) |
| | PPAT | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (551 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | ENSUAMP00000037152 | Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (178 aa) |
| | NT5C2 | 5'-nucleotidase, cytosolic II. (569 aa) |
