(62 nodes) Mixed, incl. Interconversion of nucleotide di- and triphosphates, and 3,5-cyclic-AMP phosphodiesterase activity network (Ursus americanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDE7A	Phosphodiesterase. (457 aa)
	ENSUAMP00000001002	Uncharacterized protein. (86 aa)
	ENSUAMP00000002393	Uncharacterized protein. (57 aa)
	ENSUAMP00000003186	Uncharacterized protein. (52 aa)
	AK3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (235 aa)
	NTPCR	Nucleoside-triphosphatase, cancer-related. (198 aa)
	NME1	Nucleoside diphosphate kinase. (152 aa)
	NME2	Nucleoside diphosphate kinase. (159 aa)
	DCTPP1	dCTP pyrophosphatase 1. (220 aa)
	CANT1	Calcium activated nucleotidase 1. (401 aa)
	ENTPD5	Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (428 aa)
	NUDT2	Nudix hydrolase 2. (148 aa)
	ENSUAMP00000007133	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (283 aa)
	ENSUAMP00000007406	PDEase domain-containing protein. (173 aa)
	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (463 aa)
	THTPA	Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). (230 aa)
	CTPS2	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (594 aa)
	ENSUAMP00000010849	PDE4_UCR domain-containing protein. (136 aa)
	AK3-2	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (283 aa)
	AK3-3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (235 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (863 aa)
	PDE1B	Phosphodiesterase. (535 aa)
	GLRX	Glutaredoxin. (106 aa)
	ITPA	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (209 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (528 aa)
	NME3	Nucleoside diphosphate kinase. (169 aa)
	ENSUAMP00000016857	Uncharacterized protein. (76 aa)
	ENTPD3	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (336 aa)
	ENTPD8	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (498 aa)
	AK2	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
	NME4	Nucleoside diphosphate kinase. (187 aa)
	ENSUAMP00000020703	TPK_catalytic domain-containing protein. (251 aa)
	ENSUAMP00000020992	ATP-cone domain-containing protein. (123 aa)
	PDE3A	Phosphodiesterase. (777 aa)
	ENSUAMP00000021520	Uncharacterized protein. (210 aa)
	NT5C3A	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
	ENSUAMP00000022965	Uncharacterized protein. (296 aa)
	ENSUAMP00000023031	Uncharacterized protein. (118 aa)
	AK6	Adenylate kinase 6. (141 aa)
	HDDC3	HD domain containing 3. (179 aa)
	AMPD3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (775 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (297 aa)
	ENTPD2	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa)
	ENSUAMP00000029679	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
	ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase 3. (868 aa)
	AK1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (245 aa)
	CTPS1	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (636 aa)
	NME6	Nucleoside diphosphate kinase. (186 aa)
	PDE4D	Phosphodiesterase. (585 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	AK8	Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa)
	PDE10A	Phosphodiesterase. (525 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	AK7	Adenylate kinase 7. (718 aa)
	PDE1A	Phosphodiesterase. (518 aa)
	ENSUAMP00000034716	Uncharacterized protein. (118 aa)
	ENSUAMP00000034767	Uncharacterized protein; Belongs to the adenylate kinase family. (120 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
	ENSUAMP00000035827	Uncharacterized protein. (175 aa)
	PDE2A	Phosphodiesterase. (975 aa)
	ENSUAMP00000037152	Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (178 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY4	ADCY6	ENSUAMP00000032005	ENSUAMP00000035722	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.973
ADCY4	ADCY7	ENSUAMP00000032005	ENSUAMP00000032396	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.668
ADCY4	ENPP1	ENSUAMP00000032005	ENSUAMP00000011314	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	0.909
ADCY4	ENPP3	ENSUAMP00000032005	ENSUAMP00000029928	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleotide pyrophosphatase/phosphodiesterase 3.	0.909
ADCY4	ENSUAMP00000002393	ENSUAMP00000032005	ENSUAMP00000002393	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.945
ADCY4	ENSUAMP00000003186	ENSUAMP00000032005	ENSUAMP00000003186	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.855
ADCY4	ENSUAMP00000007406	ENSUAMP00000032005	ENSUAMP00000007406	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PDEase domain-containing protein.	0.855
ADCY4	ENSUAMP00000010849	ENSUAMP00000032005	ENSUAMP00000010849	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	PDE4_UCR domain-containing protein.	0.891
ADCY4	ENSUAMP00000021520	ENSUAMP00000032005	ENSUAMP00000021520	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.893
ADCY4	ENSUAMP00000022965	ENSUAMP00000032005	ENSUAMP00000022965	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.893
ADCY4	ENSUAMP00000034716	ENSUAMP00000032005	ENSUAMP00000034716	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.855
ADCY4	ENSUAMP00000035827	ENSUAMP00000032005	ENSUAMP00000035827	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.871
ADCY4	ENTPD2	ENSUAMP00000032005	ENSUAMP00000029373	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family.	0.879
ADCY4	ENTPD3	ENSUAMP00000032005	ENSUAMP00000017223	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family.	0.949
ADCY4	ENTPD8	ENSUAMP00000032005	ENSUAMP00000018610	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family.	0.875
ADCY4	ITPA	ENSUAMP00000032005	ENSUAMP00000012877	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.	0.943
ADCY4	NME1	ENSUAMP00000032005	ENSUAMP00000004965	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Nucleoside diphosphate kinase.	0.834
ADCY4	NME2	ENSUAMP00000032005	ENSUAMP00000004968	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Nucleoside diphosphate kinase.	0.834
ADCY4	NME3	ENSUAMP00000032005	ENSUAMP00000016764	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Nucleoside diphosphate kinase.	0.834
ADCY4	NME4	ENSUAMP00000032005	ENSUAMP00000019910	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Nucleoside diphosphate kinase.	0.871